Johns Hopkins University Clinical Trial Pipeline: 382 Active Trials, 69 Changes This Month

38 trials changed in the last 30 days: 3 stopped, 22 with notable changes, 13 with minor changes only.

Stopped

Dupilumab De-escalation in Pediatric Atopic Dermatitis

Trial terminated

Also in this update: Final enrollment: 1 participants — 3% of the 30 planned; Primary completion date changed from estimate of Apr 1, 2027 to Jul 18, 2026

Johns Hopkins UniversityPhase 4 NCT06116526 Registry history of NCT06116526 on ClinicalTrials.gov (opens the registry)

Oct 19, 2026
Stopped

KETO-SLEEP 2 · Impact of Exogenous Ketones on Sleep Apnea

Withdrawn before enrolling

Also in this update: Primary completion date changed from estimate of Sep 6, 2028 to Sep 15, 2026

Johns Hopkins UniversityPhase 1/2 NCT06687655 Registry history of NCT06687655 on ClinicalTrials.gov (opens the registry)

Sep 21, 2026
Stopped

Tele-Wellness Supported App for Family Child Care Home Providers and Families to Promote Health, Family Engagement, and School Readiness Amid COVID-19

Trial status changed: Enrolling by Invitation → Suspended

Also in this update: Primary and study completion pushed from Sep 2026 to Dec 2026; Final enrollment: 35 participants (planned 270)

Johns Hopkins UniversityNot applicable NCT04453657 Registry history of NCT04453657 on ClinicalTrials.gov (opens the registry)

Sep 21, 2026
Notable

Improving Cardiovascular Health Risks · Epilepsy on a Modified Atkins Diet

Primary completion pushed from Jan 2027 to Jun 2028

Also in this update: Study completion pushed from Dec 2027 to Dec 2028

Johns Hopkins UniversityPhase 1/2 NCT06369571 Registry history of NCT06369571 on ClinicalTrials.gov (opens the registry)

Oct 19, 2026
Notable

UNLOAD-HF · Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure

Primary completion pushed from Sep 2026 to Sep 2027

Also in this update: Study completion pushed from Mar 2027 to Sep 2027

Johns Hopkins UniversityNot applicable NCT06364644 Registry history of NCT06364644 on ClinicalTrials.gov (opens the registry)

Oct 14, 2026
Notable

Bedroom Environment Sleep Intervention at Home for Older Adults Living Alone With Memory Concerns

Primary and study completion pushed from Jun 2028 to Feb 2029

Johns Hopkins UniversityNot applicable NCT07440498 Registry history of NCT07440498 on ClinicalTrials.gov (opens the registry)

Oct 9, 2026
Notable

Use of a Patient-Centered Electronic App to Increase ED Patient's Knowledge on HCV to Improve the HCV Care Continuum

Primary completion pushed from Sep 2026 to Apr 2027

Also in this update: Study completion pushed from Dec 2026 to Jul 2027

Johns Hopkins UniversityNot applicable NCT04162938 Registry history of NCT04162938 on ClinicalTrials.gov (opens the registry)

Sep 29, 2026
Notable

American Lung Association (ALA) Lung Health Cohort

Primary and study completion pushed from Sep 2026 to Jun 30, 2027

Johns Hopkins UniversityNot specified NCT04543461 Registry history of NCT04543461 on ClinicalTrials.gov (opens the registry)

Sep 23, 2026
Notable

Cannabidiol (CBD) on a Fixed Dose of Delta-9-tetrahydrocannabinol (THC)

Primary endpoint(s) modified

Johns Hopkins UniversityPhase 1 NCT07870187 Registry history of NCT07870187 on ClinicalTrials.gov (opens the registry)

Oct 15, 2026
Notable

Nurse Case Management Intervention to Improve MDR-TB/HIV Co-Infection Outcomes

Primary endpoint(s) modified

Also in this update: Results posted: Oct 6, 2026; Trial completed

Johns Hopkins UniversityNot applicable NCT02129244 Registry history of NCT02129244 on ClinicalTrials.gov (opens the registry)

Oct 6, 2026
Notable

PICU Up! · "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children

Primary endpoint(s) modified

Also in this update: Results posted: Oct 1, 2026; Trial completed

Johns Hopkins UniversityNot applicable NCT04989790 Registry history of NCT04989790 on ClinicalTrials.gov (opens the registry)

Oct 1, 2026
Notable

Cannabidiol as an Adjunct Treatment for Alcohol Withdrawal and Craving

Recruitment opened

Johns Hopkins UniversityPhase 2/3 NCT07148843 Registry history of NCT07148843 on ClinicalTrials.gov (opens the registry)

Oct 2, 2026
Notable

Epi-Pre · Epidiolex Trial for Presymptomatic Treatment of Sturge-Weber Syndrome

Recruitment opened

Johns Hopkins UniversityPhase 2 NCT07778810 Registry history of NCT07778810 on ClinicalTrials.gov (opens the registry)

Sep 25, 2026
Notable

Tirzepatide · CCCA

Recruitment opened

Johns Hopkins UniversityPhase 2 NCT07734870 Registry history of NCT07734870 on ClinicalTrials.gov (opens the registry)

Sep 23, 2026
Notable

Multimodal Glucose Prediction in Type 2 Diabetes

Recruitment opened

Also in this update: Start date changed from estimate of Oct 1, 2026 to Oct 7, 2026

Johns Hopkins UniversityNot specified NCT07633171 Registry history of NCT07633171 on ClinicalTrials.gov (opens the registry)

Oct 8, 2026
Notable

THRIVE · Peer Support for Liver Transplant Recipients With History of ALD

Recruitment opened

Also in this update: Start date pushed from Sep 2026 to Oct 2026

Johns Hopkins UniversityNot applicable NCT07397598 Registry history of NCT07397598 on ClinicalTrials.gov (opens the registry)

Oct 6, 2026
Notable

SDM in CKM · Team-Based Shared Decision-Making Program in Cardiovascular-Kidney-Metabolic Health (Healthy Heart - CKM)

Start date pushed from Sep 30, 2026 to Oct 30, 2026

Johns Hopkins UniversityEarly Phase 1 NCT07662616 Registry history of NCT07662616 on ClinicalTrials.gov (opens the registry)

Oct 19, 2026
Notable

INTERLUNG · INTERvening for LUNG Health Trial

Start date pushed from Oct 15, 2026 to Nov 15, 2026

Johns Hopkins UniversityPhase 4 NCT07540000 Registry history of NCT07540000 on ClinicalTrials.gov (opens the registry)

Oct 8, 2026
Notable

Herbal Supplement (Biocidin REMOVE) for Bacterial Overgrowth in Irritable Bowel Syndrome

Start date pushed from Oct 1, 2026 to Nov 1, 2026

Johns Hopkins UniversityPhase 2 NCT07768267 Registry history of NCT07768267 on ClinicalTrials.gov (opens the registry)

Oct 8, 2026
Notable

PRISMatic · Psilocybin Efficacy With or Without Pimavanserin Pretreatment

Start date pushed from Sep 30, 2026 to Oct 30, 2026

Johns Hopkins UniversityPhase 1/2 NCT07610135 Registry history of NCT07610135 on ClinicalTrials.gov (opens the registry)

Oct 1, 2026

Show 13 trials with minor changes only

Minor

LINKED-HEARTS · Cardiometabolic Health Program Linked With Clinical-Community Support and Mobile Health Telemonitoring to Reduce Health Disparities

Enrollment closed, study ongoing

Johns Hopkins UniversityNot applicable NCT05321368 Registry history of NCT05321368 on ClinicalTrials.gov (opens the registry)

Oct 13, 2026
Minor

AGB101 PDP · AGB101 · Parkinson's Disease Related Psychosis

Enrollment closed, study ongoing

Johns Hopkins UniversityPhase 2 NCT05824728 Registry history of NCT05824728 on ClinicalTrials.gov (opens the registry)

Oct 7, 2026
Minor

Metformin IN Asthma for Overweight and Obese Individuals (MINA)

Primary completion pushed from Sep 30, 2026 to Dec 31, 2026

Johns Hopkins UniversityPhase 2 NCT06273072 Registry history of NCT06273072 on ClinicalTrials.gov (opens the registry)

Oct 16, 2026
Minor

K-BREATHE · Impact of Exogenous Ketones on Breathing in Healthy Volunteers

Trial completed

Also in this update: Primary completion date changed from estimate of Jan 10, 2027 to Sep 3, 2026

Johns Hopkins UniversityEarly Phase 1 NCT07220122 Registry history of NCT07220122 on ClinicalTrials.gov (opens the registry)

Sep 28, 2026
Minor

K-SLEEP · Impact of Exogenous Ketones on Sleep and Breathing in Healthy Volunteers (K-SLEEP)

Trial completed

Also in this update: Primary completion date changed from estimate of Jan 1, 2028 to Sep 3, 2026

Johns Hopkins UniversityPhase 1 NCT07224074 Registry history of NCT07224074 on ClinicalTrials.gov (opens the registry)

Sep 28, 2026
Minor

1MoreStep: An Intervention to Increase HIV Care Engagement and Reduce Intimate Partner Violence Among Black Women Living With HIV

Trial completed

Also in this update: Final enrollment: 56 participants (planned 100); Primary completion date changed from estimate of Sep 2026 to May 18, 2026

Johns Hopkins UniversityNot applicable NCT05608421 Registry history of NCT05608421 on ClinicalTrials.gov (opens the registry)

Sep 24, 2026
Minor

TREAT-MS · Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial

Trial completed

Johns Hopkins UniversityNot applicable NCT03500328 Registry history of NCT03500328 on ClinicalTrials.gov (opens the registry)

Sep 23, 2026
Minor

SEPVADIS · Sildenafil for Early Pulmonary Vascular Disease in Scleroderma

Primary and study completion pushed from Sep 1, 2026 to Nov 1, 2026

Johns Hopkins UniversityPhase 2 NCT04797286 Registry history of NCT04797286 on ClinicalTrials.gov (opens the registry)

Sep 28, 2026
Minor

ACCESS2 · AI for pediatriC diabetiC Eye examS Study 2

Primary and study completion pushed from Sep 30, 2026 to Dec 30, 2026

Johns Hopkins UniversityNot applicable NCT05463289 Registry history of NCT05463289 on ClinicalTrials.gov (opens the registry)

Sep 23, 2026
Minor

Cancer Driving Mutations in Endometriosis Lesions and Development of Progesterone Resistance

Study completion pushed from Oct 1, 2026 to Oct 1, 2027

Johns Hopkins UniversityNot specified NCT03756480 Registry history of NCT03756480 on ClinicalTrials.gov (opens the registry)

Oct 14, 2026
Minor

Empowering Pain Psychology Access and Collaboration (EPPAC) to Improve Treatment Engagement Among Medicaid-insured · Chronic Low Back Pain

Start date pushed from Oct 15, 2026 to Nov 2, 2026

Johns Hopkins UniversityNot applicable NCT07843706 Registry history of NCT07843706 on ClinicalTrials.gov (opens the registry)

Oct 9, 2026
Minor

Personalized Closed-Loop Brain Stimulation · Primary Progressive Aphasia

Start date pushed from Sep 2026 to Oct 2026

Johns Hopkins UniversityNot applicable NCT07511179 Registry history of NCT07511179 on ClinicalTrials.gov (opens the registry)

Oct 1, 2026
Minor

Scrambler Therapy in Chronic Pancreatitis

Study completion pushed from Dec 1, 2026 to Dec 1, 2027

Johns Hopkins UniversityNot applicable NCT07174609 Registry history of NCT07174609 on ClinicalTrials.gov (opens the registry)

Sep 29, 2026

Stopped: an ongoing trial was terminated, suspended or withdrawn.
Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
Minor: routine progress and housekeeping, such as sites added or enrollment closed.

First posted	Trial	Phase	Status
2026-10-16	NCT07877987 The Impact of Dose on the Impairing, Intoxicating, and Abuse-Related Effects of Psilocybin	Phase 1	Not Yet Recruiting
2026-10-13	NCT07870187 Effects of Cannabidiol (CBD) on a Fixed Dose of Delta-9-tetrahydrocannabinol (THC)	Phase 1	Not Yet Recruiting
2026-10-09	NCT07868393 Prevention and Rapid Outreach for Treatment, Engagement, and Care Transition From the…		Not Yet Recruiting
2026-10-07	NCT07863583 Social Connection Collective for Older Adults in Subsidized Housing		Recruiting
2026-09-30	NCT07850102 Brain Imaging of DSP-2342	Phase 2	Not Yet Recruiting
2026-09-29	NCT07845552 Oral Food Challenge After One to Two Doses of Omalizumab Treatment for Food Allergy	Phase 4	Not Yet Recruiting
2026-09-29	NCT07846189 Rhythmic Entrainment and Alertness in Lewy Body Dementia		Not Yet Recruiting
2026-09-28	NCT07843706 Empowering Pain Psychology Access and Collaboration (EPPAC) to Improve Treatment…		Not Yet Recruiting

Johns Hopkins University clinical trial pipeline

What changed in the last 30 days

Dupilumab De-escalation in Pediatric Atopic Dermatitis

KETO-SLEEP 2 · Impact of Exogenous Ketones on Sleep Apnea

Tele-Wellness Supported App for Family Child Care Home Providers and Families to Promote Health, Family Engagement, and School Readiness Amid COVID-19

Improving Cardiovascular Health Risks · Epilepsy on a Modified Atkins Diet

UNLOAD-HF · Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure

Bedroom Environment Sleep Intervention at Home for Older Adults Living Alone With Memory Concerns

Use of a Patient-Centered Electronic App to Increase ED Patient's Knowledge on HCV to Improve the HCV Care Continuum

American Lung Association (ALA) Lung Health Cohort

Cannabidiol (CBD) on a Fixed Dose of Delta-9-tetrahydrocannabinol (THC)

Nurse Case Management Intervention to Improve MDR-TB/HIV Co-Infection Outcomes

PICU Up! · "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children

Cannabidiol as an Adjunct Treatment for Alcohol Withdrawal and Craving

Epi-Pre · Epidiolex Trial for Presymptomatic Treatment of Sturge-Weber Syndrome

Tirzepatide · CCCA

Multimodal Glucose Prediction in Type 2 Diabetes

THRIVE · Peer Support for Liver Transplant Recipients With History of ALD

SDM in CKM · Team-Based Shared Decision-Making Program in Cardiovascular-Kidney-Metabolic Health (Healthy Heart - CKM)

INTERLUNG · INTERvening for LUNG Health Trial

Herbal Supplement (Biocidin REMOVE) for Bacterial Overgrowth in Irritable Bowel Syndrome

PRISMatic · Psilocybin Efficacy With or Without Pimavanserin Pretreatment

LINKED-HEARTS · Cardiometabolic Health Program Linked With Clinical-Community Support and Mobile Health Telemonitoring to Reduce Health Disparities

AGB101 PDP · AGB101 · Parkinson's Disease Related Psychosis

Metformin IN Asthma for Overweight and Obese Individuals (MINA)

K-BREATHE · Impact of Exogenous Ketones on Breathing in Healthy Volunteers

K-SLEEP · Impact of Exogenous Ketones on Sleep and Breathing in Healthy Volunteers (K-SLEEP)

1MoreStep: An Intervention to Increase HIV Care Engagement and Reduce Intimate Partner Violence Among Black Women Living With HIV

TREAT-MS · Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial

SEPVADIS · Sildenafil for Early Pulmonary Vascular Disease in Scleroderma

ACCESS2 · AI for pediatriC diabetiC Eye examS Study 2

Cancer Driving Mutations in Endometriosis Lesions and Development of Progesterone Resistance

Empowering Pain Psychology Access and Collaboration (EPPAC) to Improve Treatment Engagement Among Medicaid-insured · Chronic Low Back Pain

Personalized Closed-Loop Brain Stimulation · Primary Progressive Aphasia

Scrambler Therapy in Chronic Pancreatitis

New trial filings, last 30 days

Active trials by phase

Disease areas by active trials, top 10 of 49

Early Phase 1		11
Phase 1		33
Phase 1/2		7
Phase 2		41
Phase 2/3		6
Phase 3		11
Phase 4		13