Also listed under Neurocognitive Disorders
108 trials changed in the last 30 days: 1 stopped, 45 with notable changes, 62 with minor changes only.
Trial status changed: Not Yet Recruiting → Suspended
Also in this update: Primary completion pushed from Jan 2027 to Nov 2027; Primary endpoint(s) modified
Poitiers University HospitalNot applicable NCT06902753 Registry history of NCT06902753 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Dec 2026 to Mar 2028
Also in this update: Study completion pushed from Jun 2027 to Jun 2028
NKGen Biotech, Inc.Phase 1/2 NCT06189963 Registry history of NCT06189963 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Jun 27, 2026 to Jun 27, 2027
University of California, DavisNot applicable NCT04141878 Registry history of NCT04141878 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Dec 2026 to Dec 31, 2027
Douglas ScharreNot specified NCT03019757 Registry history of NCT03019757 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Oct 1, 2026 to Oct 1, 2027
Heinrich-Heine University, DuesseldorfNot specified NCT06313944 Registry history of NCT06313944 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Aug 28, 2026 to Nov 28, 2027
Also in this update: Study completion pushed from Oct 2026 to Mar 30, 2028
Cedars-Sinai Medical CenterNot applicable NCT07224607 Registry history of NCT07224607 on ClinicalTrials.gov (opens the registry)
Primary endpoint(s) modified
Also in this update: Study completion moved earlier from Dec 2027 to Oct 2027
AriBio Co., Ltd.Phase 3 NCT05531526 Registry history of NCT05531526 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Dec 2025 to Mar 2027
Monash UniversityNot specified NCT06339190 Registry history of NCT06339190 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Apr 30, 2026 to Sep 30, 2029
Also in this update: Enrollment reopened; Study completion pushed from Nov 1, 2026 to Nov 30, 2029
Aristotle University Of ThessalonikiNot applicable NCT06705738 Registry history of NCT06705738 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Sep 16, 2026 to Mar 16, 2027
Also in this update: Study completion pushed from Dec 7, 2026 to May 7, 2027
University of FloridaNot applicable NCT05910619 Registry history of NCT05910619 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Sep 2026 to Sep 2031
Washington University School of MedicineNot specified NCT00869817 Registry history of NCT00869817 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Jun 2026 to May 2027
Also in this update: Study completion pushed from Jun 2026 to Jun 2027
University of ManitobaNot applicable NCT06419257 Registry history of NCT06419257 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Apr 30, 2026 to Dec 30, 2026
Also in this update: Enrollment closed, study ongoing
HudsonAlpha Institute for BiotechnologyNot applicable NCT07146412 Registry history of NCT07146412 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Nov 30, 2025 to Nov 30, 2027
Also in this update: Study completion pushed from Dec 30, 2026 to Dec 30, 2028
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sNot applicable NCT05375513 Registry history of NCT05375513 on ClinicalTrials.gov (opens the registry)
Primary endpoint(s) modified
Also in this update: Study completion pushed from Apr 30, 2029 to Apr 30, 2030
Merck Sharp & Dohme LLCPhase 2 NCT07033494 Registry history of NCT07033494 on ClinicalTrials.gov (opens the registry)
Primary endpoint(s) modified
Also in this update: Trial completed; Primary completion date changed from estimate of Dec 2026 to Mar 6, 2026
Elixiron Immunotherapeutics Inc.Phase 2 NCT06745583 Registry history of NCT06745583 on ClinicalTrials.gov (opens the registry)
Primary endpoint(s) modified
Also in this update: Trial completed; Primary completion date changed from estimate of Nov 30, 2026 to Sep 16, 2026
University of Maryland, BaltimoreNot specified NCT04201600 Registry history of NCT04201600 on ClinicalTrials.gov (opens the registry)
Primary endpoint(s) modified
Institute for Molecular MedicinePhase 2 NCT07827768 Registry history of NCT07827768 on ClinicalTrials.gov (opens the registry)
Primary endpoint(s) modified
The Methodist Hospital Research InstitutePhase 1/2 NCT07651319 Registry history of NCT07651319 on ClinicalTrials.gov (opens the registry)
Primary endpoint(s) modified
Also in this update: Trial completed; Primary completion date changed from estimate of Sep 2026 to Jun 30, 2026
Emory UniversityNot applicable NCT06250725 Registry history of NCT06250725 on ClinicalTrials.gov (opens the registry)
Trial status changed: Enrolling by Invitation → Recruiting
ACADIA Pharmaceuticals Inc.Phase 3 NCT07095465 Registry history of NCT07095465 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Also in this update: Primary and study completion moved earlier from Jun 7, 2028 to Feb 16, 2028; Final enrollment: 1101 participants (planned 800)
Hoffmann-La RochePhase 3 NCT07169578 Registry history of NCT07169578 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Also in this update: Trial sites reduced: 150 → 147 locations; Primary and study completion moved earlier from Jun 7, 2028 to Feb 16, 2028
Hoffmann-La RochePhase 3 NCT07170150 Registry history of NCT07170150 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Primary completion date changed from estimate of May 31, 2026 to Sep 30, 2025; Final enrollment: 50 participants (planned 70)
HiDO TechnologiesPhase 2 NCT06691256 Registry history of NCT06691256 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Also in this update: Primary and study completion pushed from Aug 2026 to Nov 2026; Trial sites reduced: 31 → 28 locations
IGC Pharma, LLCPhase 2 NCT05543681 Registry history of NCT05543681 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Jul 2030 to Sep 2030
Also in this update: Trial sites expanded: 9 → 12 locations; Start date pushed from Oct 2026 to Nov 2026
Eli Lilly and CompanyPhase 4 NCT07838155 Registry history of NCT07838155 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Primary completion date changed from estimate of Aug 2026 to Jun 25, 2026; Final enrollment: 7 participants (planned 18)
Regeneration Biomedical, Inc.Phase 1 NCT05667649 Registry history of NCT05667649 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Final enrollment: 10 participants (planned 60)
Yale UniversityNot applicable NCT06940687 Registry history of NCT06940687 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Primary completion date changed from estimate of Jul 31, 2026 to Mar 22, 2026; Final enrollment: 420 participants (planned 355)
Mayo ClinicNot applicable NCT05779839 Registry history of NCT05779839 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Also in this update: Primary and study completion pushed from Apr 2029 to Jun 2029
Tor Biering-SørensenPhase 4 NCT07485283 Registry history of NCT07485283 on ClinicalTrials.gov (opens the registry)
Trial status changed: Not Yet Recruiting → Active, Not Recruiting
Eisai Inc.Not specified NCT07723950 Registry history of NCT07723950 on ClinicalTrials.gov (opens the registry)
Completed without a posted recruiting period
Also in this update: Primary completion date changed from estimate of Jul 2026 to Sep 28, 2026; Final enrollment: 43 participants (planned 62)
University of SalamancaNot applicable NCT07388186 Registry history of NCT07388186 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Jul 1, 2028 to Dec 1, 2028
BioSensicsNot specified NCT07240805 Registry history of NCT07240805 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Primary completion date changed from estimate of Nov 2026 to Sep 1, 2026; Final enrollment: 21 participants (planned 30)
Association de Recherche Bibliographique pour les NeurosciencesNot applicable NCT06785948 Registry history of NCT06785948 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Poitiers University HospitalNot applicable NCT05939362 Registry history of NCT05939362 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Final enrollment: 86 participants (planned 180)
Weill Medical College of Cornell UniversityPhase 2 NCT03649724 Registry history of NCT03649724 on ClinicalTrials.gov (opens the registry)
Trial completed
University of FloridaPhase 2 NCT04018092 Registry history of NCT04018092 on ClinicalTrials.gov (opens the registry)
Trial completed
Massachusetts General HospitalNot applicable NCT07424443 Registry history of NCT07424443 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Study completion date changed from estimate of Apr 15, 2026 to Mar 12, 2026; Final enrollment: 42 participants (planned 70)
The University of QueenslandNot applicable NCT05528302 Registry history of NCT05528302 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 229 → 234 locations
And 1 more change in the last 30 days
Hoffmann-La RochePhase 3 NCT07177352 Registry history of NCT07177352 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Duke UniversityNot applicable NCT06088810 Registry history of NCT06088810 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Apr 1, 2029 to Jul 1, 2029
Brigham and Women's HospitalNot applicable NCT06819852 Registry history of NCT06819852 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Jun 30, 2026 to Nov 30, 2026
Virginia Commonwealth UniversityNot specified NCT06095284 Registry history of NCT06095284 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Also in this update: Primary and study completion pushed from Sep 15, 2026 to Dec 15, 2026
TC Erciyes UniversityNot applicable NCT07816731 Registry history of NCT07816731 on ClinicalTrials.gov (opens the registry)
Trial status changed: Recruiting → Not Yet Recruiting
Baylor College of MedicineNot applicable NCT06835283 Registry history of NCT06835283 on ClinicalTrials.gov (opens the registry)
Trial status changed: Unknown → Completed
Also in this update: Final enrollment: 7 participants (planned 28)
Washington State UniversityNot applicable NCT06397339 Registry history of NCT06397339 on ClinicalTrials.gov (opens the registry)
Trial completed
Alaine E Hernandez, PhDNot applicable NCT06605157 Registry history of NCT06605157 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Also in this update: Primary completion moved earlier from May 31, 2027 to Apr 30, 2027; Final enrollment: 101 participants (planned 120)
University of PittsburghNot applicable NCT06565169 Registry history of NCT06565169 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Study completion date changed from estimate of Oct 2026 to Aug 25, 2026
University of WashingtonNot applicable NCT06817122 Registry history of NCT06817122 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Kaiser PermanenteNot applicable NCT06362824 Registry history of NCT06362824 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Dec 2027 to Feb 2028
Maastricht University Medical CenterNot applicable NCT06832761 Registry history of NCT06832761 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 24 → 31 locations
Skyhawk Therapeutics, Inc.Phase 2/3 NCT07378644 Registry history of NCT07378644 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 154 → 157 locations
Karuna Therapeutics, Inc., a Bristol Myers Squibb companyPhase 3 NCT06126224 Registry history of NCT06126224 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 7 → 34 locations
Hoffmann-La RochePhase 3 NCT07717411 Registry history of NCT07717411 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 3 → 10 locations
Alnylam PharmaceuticalsPhase 2 NCT07636811 Registry history of NCT07636811 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Nov 30, 2027 to Dec 31, 2027
Education University of Hong KongNot applicable NCT07444866 Registry history of NCT07444866 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 82 → 117 locations
Novartis PharmaceuticalsPhase 3 NCT07326709 Registry history of NCT07326709 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 293 → 296 locations
Karuna Therapeutics, Inc., a Bristol Myers Squibb companyPhase 3 NCT06585787 Registry history of NCT06585787 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 55 → 62 locations
MapLight TherapeuticsPhase 2 NCT06887192 Registry history of NCT06887192 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 14 → 20 locations
Alpha Cognition, IncPhase 4 NCT07633470 Registry history of NCT07633470 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 1 → 11 locations
SanofiPhase 2 NCT07688213 Registry history of NCT07688213 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 11 → 15 locations
Eli Lilly and CompanyPhase 1 NCT07598370 Registry history of NCT07598370 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 10 → 16 locations
Eli Lilly and CompanyPhase 1 NCT07787182 Registry history of NCT07787182 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 1 → 13 locations
Also in this update: Interventions modified; Study completion pushed from Jul 30, 2028 to Oct 31, 2028
Second Affiliated Hospital of Wenzhou Medical UniversityNot applicable NCT06452147 Registry history of NCT06452147 on ClinicalTrials.gov (opens the registry)
Start date pushed from Sep 2026 to Oct 2026
Callahan-Young LLC DBA JigsawdioNot applicable NCT07839286 Registry history of NCT07839286 on ClinicalTrials.gov (opens the registry)
Start date pushed from Oct 1, 2026 to Oct 14, 2026
University Hospitals Cleveland Medical CenterPhase 1 NCT07531940 Registry history of NCT07531940 on ClinicalTrials.gov (opens the registry)
Study completion pushed from Feb 2027 to Jun 2027
Dartmouth-Hitchcock Medical CenterNot applicable NCT07631247 Registry history of NCT07631247 on ClinicalTrials.gov (opens the registry)
Study completion pushed from Jul 31, 2026 to May 31, 2027
Rush University Medical CenterNot applicable NCT04337255 Registry history of NCT04337255 on ClinicalTrials.gov (opens the registry)
Study completion moved earlier from Feb 1, 2028 to Feb 2027
Also in this update: Primary completion moved earlier from Aug 1, 2027 to Feb 2027
Yale UniversityNot applicable NCT07602283 Registry history of NCT07602283 on ClinicalTrials.gov (opens the registry)
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Recruiting
HAII corp.ltdNot applicable NCT06615167 Registry history of NCT06615167 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Not Yet Recruiting
Danish Dementia Research CentreNot specified NCT06621758 Registry history of NCT06621758 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Recruiting
Yonsei UniversityPhase 2 NCT06537076 Registry history of NCT06537076 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Not Yet Recruiting
BaermedPhase 1 NCT06632470 Registry history of NCT06632470 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Not Yet Recruiting
King's College LondonNot applicable NCT06768450 Registry history of NCT06768450 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Recruiting
Universidad de BurgosNot applicable NCT06623864 Registry history of NCT06623864 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Not Yet Recruiting
Oxleas NHS Foundation TrustNot applicable NCT06611202 Registry history of NCT06611202 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Jun 2023); last known: Not Yet Recruiting
The Hong Kong Polytechnic UniversityNot applicable NCT05927805 Registry history of NCT05927805 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since May 2023); last known: Not Yet Recruiting
Universidade do PortoNot applicable NCT05890313 Registry history of NCT05890313 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Recruiting
IRCCS Centro San Giovanni di Dio FatebenefratelliNot applicable NCT05730023 Registry history of NCT05730023 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Feb 2023); last known: Enrolling by Invitation
Fundacion CITA-alzheimerNot applicable NCT04840030 Registry history of NCT04840030 on ClinicalTrials.gov (opens the registry)
Changed
Registry verification sweep
Changed
Registry marked status Unknown (sponsor has not verified the record since Mar 2024); last known: Recruiting
University Gustave EiffelNot specified NCT06320639 Registry history of NCT06320639 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Oct 2023); last known: Not Yet Recruiting
First Hospital of China Medical UniversityNot specified NCT06081569 Registry history of NCT06081569 on ClinicalTrials.gov (opens the registry)
Changed
Registry verification sweep
Changed
| First posted | Trial | Sponsor | Phase |
|---|---|---|---|
| 2026-10-02 | NCT07856043 [11C]PS13 PET Imaging of Neuroinflammation in Heart Failure With Reduced Ejection Fraction | Stony Brook University new | Phase 1 |
| 2026-10-02 | NCT07854327 Restoring Cervical Lymphatic Drainage in Alzheimer's Disease | University of Siena new | |
| 2026-09-29 | NCT07846566 Choose Myself (Before) Losing Myself | The Cleveland Clinic new | |
| 2026-09-28 | NCT07844980 Impact of Social Support Through Personalized Visits on Behavioral Symptoms in… | University of South Alabama new | |
| 2026-09-25 | NCT07842029 Evaluation of Blood-Based Biomarkers and Remote Cognitive Assessment for Dementia Triage… | Prima Mente new | |
| 2026-09-24 | NCT07839286 Jigsawdio Multisensory Platform for People With Mild Cognitive Impairment, Alzheimer's… | Callahan-Young LLC DBA Jigsawdio new | |
| 2026-09-22 | NCT07835399 Efficacy and Safety of Photobiomodulation Therapy in Patients With Mild Cognitive… | Jun Xu new | |
| 2026-09-18 | NCT07827196 Transcranial Random Noise (tRNS) for BPSD in Alzheimer's Disease: A Double-blind… | Anhui Medical University new | |
| 2026-09-18 | NCT07828600 Effects of Application of Oral Moisturizers on Microbiota Homeostasis in Long-Term Care… | Meiho University new | |
| 2026-09-14 | NCT07816731 EFFECT OF FACE-TO-FACE AND VIRTUAL REALITY-BASED SALUTOGENESIS NURSING CARE IN PATIENTS… | TC Erciyes University new |
| Early Phase 1 | 21 | |
| Phase 1 | 75 | |
| Phase 1/2 | 51 | |
| Phase 2 | 140 | |
| Phase 2/3 | 18 | |
| Phase 3 | 70 | |
| Phase 4 | 32 |
Xuanwu Hospital, Beijing (23) · Eli Lilly and Company (19) · Mayo Clinic (19) · Washington University School of Medicine (19) · Johns Hopkins University (17) · Assistance Publique - Hôpitaux de Paris (15) · Massachusetts General Hospital (15) · Chang Gung Memorial Hospital (13) · Indiana University (13) · Hoffmann-La Roche (11)