Disease landscape

Dementia clinical trials

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675 active trials 374 recruiting 28 Phase 3 412 sponsors 97 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 46 of 97 changes on 20 trials

2026-09-05
Primary completion pushed: 2026-10 → 2029-10
Completion pushed: 2026-10 → 2029-12
NCT06597942 Large-coil Parietal Repetitive Transcranial Magnetic Stimulation (rTMS) for Alzheimer… · University of California, Los Angeles · Phase 1/2
2026-08-14
Primary completion pushed: 2026-04-01 → 2027-04-01
NCT06064890 A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects… · AviadoBio Ltd · Phase 1/2
2026-09-05
Primary completion pushed: 2026-03-22 → 2026-09-22
Trial status changed: Enrolling by Invitation → Active, Not Recruiting
Completion pushed: 2026-03-22 → 2026-09-22
NCT06940687 Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their… · Yale University
2026-09-04
Primary completion pushed: 2026-08-31 → 2029-07-31
Completion pushed: 2026-08-31 → 2029-07-31
NCT06703541 ADRC Clinical Cohort (Alzheimer's Disease) · Duke University
2026-09-04
Primary completion pushed: 2026-06 → 2030-06
Completion pushed: 2026-06 → 2030-06
NCT05491980 Florida Cerebrovascular Disease Biorepository and Genomics Center · Mayo Clinic
2026-09-03
Primary completion pushed: 2025-10 → 2026-10
Completion pushed: 2026-01 → 2027-01
NCT06292741 Autonomic Involvement in Patient With Cognitive Decline · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
2026-09-03
Primary completion pushed: 2028-05 → 2028-09
Completion pushed: 2028-07 → 2028-12
NCT07200739 Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients… · Zealand University Hospital
2026-08-25
Primary completion pushed: 2026-01-31 → 2028-01-31
Enrollment closed, study ongoing
Completion pushed: 2026-01-31 → 2028-01-31
NCT03848312 Preventing Alzheimer's With Cognitive Training · University of South Florida · Phase 3
2026-08-29
Primary completion pushed: 2026-04 → 2027-04
Enrollment closed, study ongoing
Completion pushed: 2026-04 → 2027-04
NCT06846658 Exploring the Olfactory Mucosa, Blood and Urine for the Identification of Early… · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
2026-08-29
Primary completion pushed: 2026-08 → 2027-02
Enrollment closed, study ongoing
Completion pushed: 2026-08 → 2027-02
NCT06856850 Disease Biosignatures in ALS/FTD Spectrum: New Impactful Biological Perspectives Beyond… · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
2026-08-19
Primary completion pushed: 2027-12 → 2028-12
NCT05586581 SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During… · Yale University · Phase 1/2
2026-08-26
Primary completion pushed: 2026-08-01 → 2026-12-01
Completion pushed: 2026-08-31 → 2026-12-31
NCT06088810 The Impact of Music Intervention on Sleep · Duke University
2026-08-11
Primary completion pushed: 2026-03 → 2026-09
Enrollment closed, study ongoing
Completion pushed: 2026-04 → 2026-09
NCT07210528 Safety Of Nrtis for Alzheimer's Therapeutic Advancement in Singapore Study · National University Hospital, Singapore · Phase 1
2026-08-22
Primary completion pushed: 2026-04 → 2026-09
Primary endpoint(s) modified
Enrollment closed, study ongoing
Completion pushed: 2026-04 → 2026-10
NCT06817122 The "Let's Talk Tech" Tool to Support Decision Making About Technology Use · University of Washington
2026-08-21
Primary completion pushed: 2026-05-31 → 2026-10-31
Enrollment closed, study ongoing
Completion pushed: 2026-05-31 → 2026-10-31
NCT05014971 Telehealth in Lewy Body Dementia · University of Florida
2026-08-21
Primary completion pushed: 2025-12-31 → 2026-12-31
Completion pushed: 2025-12-31 → 2026-12-31
NCT07146581 Technology-Based Intervention Pilot Testing · Weill Medical College of Cornell University
2026-08-13
Primary completion pushed: 2028-05 → 2029-04-01
Completion pushed: 2028-05 → 2029-04-01
NCT06819852 Acute Hospital Care at Home for People Living With Dementia · Brigham and Women's Hospital
2026-08-11
Primary completion pushed: 2027-12-31 → 2029-12-31
Completion pushed: 2027-12-31 → 2029-12-31
NCT06209515 Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease… · Kuopio University Hospital
2026-08-07
Primary completion pushed: 2026-06 → 2026-12
Completion pushed: 2026-10 → 2027-02
NCT05879211 Goal Concordant Care Learning Laboratory · Duke University
2026-08-07
Primary completion pushed: 2026-06-30 → 2026-09-30
Completion pushed: 2026-08-31 → 2026-11-30
NCT07216716 Evaluating the Effectiveness of the Health App Recommendation Tool · University of Pittsburgh

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-21 NCT07778329 Psychosocial Intervention for Behavioral Symptoms in Hospitalized Patients With Dementia… Azienda Ospedaliero-Universitaria di Modena new
2026-08-17 NCT07766993 Developing and Testing an AI-Based Cognitive Intervention Program National Research Center for Rehabilitation Technical Aids new
2026-08-13 NCT07763392 Establishing Normal Cognitive Test Scores for Adults Using a Voice-Enabled Digital… The Neurology Center of Southern California new
2026-08-11 NCT07757204 An Open-label Long-term Safety Study of Buntanetap in Participants With AD Annovis Bio Inc. new Phase 2/3
2026-08-11 NCT07758660 Alzheimer's Disease Research Center (ADRC) PET Component Study Patrick Lao new Phase 2
2026-08-10 NCT07755631 The BASIC-S Feasibility Study for Vascular Risk Reduction Andrew Appleton new
2026-08-05 NCT07747610 Effects of Lifestyle and Cognitive Play-Based Nursing Intervention on Dementia Risk Al-Zaytoonah University of Jordan new
2026-07-23 NCT07721701 Digital Dementia Registry Bavaria (digiDEM Bayern): a Multicentre, Prospective… University of Erlangen-Nürnberg Medical School new
2026-07-22 NCT07718906 Neuromodulation for Behavioral Changes in Neurological Disorders West Virginia University new
2026-07-14 NCT07700615 Mexidol® Efficacy and Safety in Treatment of VCIND in Older Adults Pharmasoft new Phase 4

Active trials by phase

Early Phase 1
6
Phase 1
13
Phase 1/2
18
Phase 2
34
Phase 2/3
10
Phase 3
18
Phase 4
11
Not charted: 565 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 675

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT04262206 Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults Duke University Recruiting 2026-09-01
NCT07604896 Evaluating the Efficacy and Safety of Lecanemab in Alzheimer's Disease Through… First Affiliated Hospital of Wenzhou Medical University Recruiting 2026-05-22
NCT07485283 Recombinant Herpes Zoster Vaccine for Prevention of Cardiovascular Events and Dementia Tor Biering-Sørensen Recruiting 2026-05-04
NCT07284290 Elucidating the Role of Cholinergic Degeneration in Cognitive Fluctuations in Lewy Body… Virginia Commonwealth University Recruiting 2026-03-06
NCT05590637 Comparing Antipsychotic Medications in LBD Over Time The University of Texas Health Science Center at San Antonio Recruiting 2025-09-09
NCT06093126 Lemborexant for Insomnia in a Patient With Dementia: An N-of-1 Trial Nova Scotia Health Authority Recruiting 2025-02-21
NCT05514106 MIBG in Aging and Neurologic Disorders Mayo Clinic Enrolling by Invitation 2026-07-30
NCT00950430 Imaging of Brain Amyloid Plaques in the Aging Population Mayo Clinic Enrolling by Invitation 2026-06-23
NCT01453127 DaTSCAN Imaging in Aging and Neurodegenerative Disease Mayo Clinic Enrolling by Invitation 2026-03-10
NCT05586750 Statins in Reducing Events in the Elderly Mind (STAREE-Mind) Imaging Substudy Monash University Active, Not Recruiting 2025-05-22
NCT06662526 Lithium for Prevention of Cognitive Declining in Mood Illnesses University of Chile Not Yet Recruiting 2024-10-30
Phase 3
NCT07083154 Mazdutide in Type 2 Diabetes With Early-Stage Cognitive Impairment (LIGHT-COG Study) The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting 2026-09-02
NCT07724132 An Evaluation of Treatments for Sustained Clinical Response (18 Months) in Symptomatic… University College, London Recruiting 2026-07-23
NCT07602582 A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM… Eli Lilly and Company Recruiting 2026-07-07
NCT07422857 Evaluate the Use of [18F]-APN-1607 PET in Subjects With AD-related Cognitive Impairment… JYAMS PET Research & Development Limited Recruiting 2026-02-20
NCT05397639 Masupirdine for the Treatment of Agitation in Dementia of the Alzheimer's Type Suven Life Sciences Limited Recruiting 2026-01-12
NCT07234695 LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down… Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau Recruiting 2026-01-12
NCT06534723 Phase 3 Clinical Trial of Wujia Yizhi Granules in the Treatment of Mild-to-moderate… Sichuan Jishengtang Pharmaceutical Co., Ltd. Recruiting 2025-12-29
NCT07251023 Efficacy and Safety of DMB-I (INN: Latrepirdine) in Patients With Alzheimer Type Dementia Bigespas LTD Recruiting 2025-12-10
NCT03848312 Preventing Alzheimer's With Cognitive Training University of South Florida Active, Not Recruiting 2026-08-24
NCT06384573 DIAN-TU Amyloid Removal Trial (ART) in Dominantly Inherited Alzheimer's Disease Washington University School of Medicine Active, Not Recruiting 2026-07-27
NCT07095465 Phase 3, Open Label Extension Study of ACP-204 in Lewy Body Dementia Psychosis ACADIA Pharmaceuticals Inc. Enrolling by Invitation 2026-07-24
NCT05532657 ACHIEVE Brain Health Follow-Up Study Johns Hopkins University Active, Not Recruiting 2026-07-21
NCT05508789 A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's… Eli Lilly and Company Active, Not Recruiting 2026-07-16
NCT05738486 A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early… Eli Lilly and Company Active, Not Recruiting 2026-06-18
See all 675 active Dementia trials with filters →

Top sponsors by active trials in this area

Washington University School of Medicine (10) · Massachusetts General Hospital (9) · Mayo Clinic (9) · The Hong Kong Polytechnic University (9) · The University of Hong Kong (9) · Duke University (7) · Ruijin Hospital (7) · University of Southern California (7) · Indiana University (6) · IRCCS San Raffaele (6)

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