Sponsor Pipeline

Massachusetts General Hospital Clinical Trial Pipeline

Data updated daily from ClinicalTrials.gov — last refresh 2026-08-16
587
Active Trials
311
Recruiting
10
Phase 3
10
Disease Areas
77
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-08-15 NCT05295446
Functional GI Disease Registry
date change Primary completion pushed: 2026-06-04 -> 2027-07-01
2026-08-15 NCT05295446
Functional GI Disease Registry
date change Completion pushed: 2026-06-04 -> 2027-07-01
2026-08-15 NCT06374498
Study to Determine the Clinical Significance of Intravascular OCT-NIRAF
Primary endpoint(s) modified
2026-08-15 NCT06374498
Study to Determine the Clinical Significance of Intravascular OCT-NIRAF
Enrollment increased: 40 -> 70 participants
2026-08-15 NCT06374498
Study to Determine the Clinical Significance of Intravascular OCT-NIRAF
Trial arms changed: 1 -> 2
2026-08-15 NCT05664516
A Study of the Effects of Oxytocin in Adults With Binge-eating Disorder
date change Primary completion pushed: 2026-12 -> 2026-12-31
2026-08-15 NCT05664516
A Study of the Effects of Oxytocin in Adults With Binge-eating Disorder
date change Completion pushed: 2026-12 -> 2027-02-28
2026-08-14 NCT04945707
Impact of Intravenous Iron Repletion On Mechanisms of Exercise InTolerance in HFpEF…
Sponsor refiled this as active, not recruiting (was completed)
2026-08-14 NCT06811272
Outpatient Epcoritamab in Large B-cell Lymphoma
Primary endpoint(s) modified
2026-08-14 NCT06811272
Outpatient Epcoritamab in Large B-cell Lymphoma
Enrollment increased: 30 -> 40 participants
2026-08-14 NCT06811272
Outpatient Epcoritamab in Large B-cell Lymphoma
Trial arms changed: 1 -> 2
2026-08-14 NCT06576050
WeighT LOSS Surgery and Comprehensive Cardiometabolic Responses to to EXercise
Trial completed
2026-08-14 NCT06576050
WeighT LOSS Surgery and Comprehensive Cardiometabolic Responses to to EXercise
date change Completion pushed: 2024-11-01 -> 2025-08-02
2026-08-13 NCT07460063
Routine vs. Early Postpartum Depression Screening: A Pragmatic Clinical Trial
date change Primary completion pushed: 2027-06 -> 2027-08
2026-08-13 NCT07460063
Routine vs. Early Postpartum Depression Screening: A Pragmatic Clinical Trial
date change Completion pushed: 2027-12 -> 2028-01
2026-08-13 NCT07359157
Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital
date change Primary completion pushed: 2026-07-01 -> 2027-05-01
2026-08-13 NCT07359157
Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital
date change Completion pushed: 2026-07-01 -> 2027-05-01
2026-08-12 NCT06316804
Mobile Mental Health Stigma Reduction Intervention Among Black Adults
date change Completion moved earlier: 2027-07-31 -> 2027-01-01
2026-08-11 NCT07420751
Assessment of Patient Experience With Auto-Captioning Glasses in…
Trial completed
2026-08-11 NCT07420751
Assessment of Patient Experience With Auto-Captioning Glasses in…
date change Primary completion moved earlier: 2026-12 -> 2026-08-06
Showing 20 of 77 changes detected in the last 30 days.
New Trial Filings, Last 30 Days
First PostedTrialPhaseStatus
2026-08-14 NCT07765836 Vilastobart+Retifanlimab in BRCA or PALB2 Deficient PC Phase 2 Not Yet Recruiting
2026-08-12 NCT07759947 Telehealth Intervention for Symptom Management and Adherence to Adjuvant Endocrine Therapy Not Yet Recruiting
2026-08-11 NCT07757880 Randomized Evaluation of Operating Room Extubation After Cardiac Surgery Not Yet Recruiting
2026-08-10 NCT07755059 Proximal Splenic Artery Embolization (PSAE) for the Treatment of Refractory Ascites in… Not Yet Recruiting
2026-07-31 NCT07739537 PATHS-T2D: A Recall-by-Genotype Study of Physiologic and Pharmacologic Responses Phase 4 Not Yet Recruiting
2026-07-29 NCT07734272 Standardized Documentation and Assessments for Polycythemia Vera: A Quality Improvement… Not Yet Recruiting
2026-07-27 NCT07728773 A Stepped Intervention for Coping With Dyspnea in Patients With Lung Cancer-Phase A (Open… Not Yet Recruiting
2026-07-27 NCT07729332 Switching to Oral Weight Management Pharmacotherapy to Prevent Weight Regain After GLP-1… Phase 4 Not Yet Recruiting
2026-07-24 NCT07725289 Clinician Practice Companion to Address Youth Substance Use Not Yet Recruiting
2026-07-23 NCT07723066 Biomarker Discovery for Suicide Precision Circuit Therapeutics Not Yet Recruiting
Active Trials by Phase
Phase 4
33
Phase 3
10
Phase 2
88
Phase 1/2
12
Phase 1
28
Early Phase 1
23
Not specified
393
Active Trials — top 25 of 587
NCT IDTitleConditionStatus
Phase 4
NCT03718403 Effect of Theophylline in Pseudohypoparathyroidism PHP Ia Recruiting
NCT04875702 Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout Gout Recruiting
NCT02283996 Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of… Adhesive Capsulitis Recruiting
NCT05450432 Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk… Major Depressive Disorder Recruiting
NCT07131592 Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction… Drain Output After Breast Reduction Surgery Recruiting
NCT07346079 Purified Cortrophin® Gel Efficacy and Safety Study of 2 Dose Levels in Patients With… Gout Arthritis Recruiting
NCT07199335 Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs HIV Recruiting
NCT06558188 Combined Anabolic Therapy Osteoporosis, Postmenopausal Recruiting
NCT07166939 45th Multicenter Airway Research Collaboration Asthma Acute Recruiting
NCT04400266 Buspirone and Melatonin for Depression Following Traumatic Brain Injury Depression Recruiting
NCT05853627 Mismatch vs. Standard Intervention During Memory Reconsolidation Blockade With… Stress Disorders, Post-Traumatic Recruiting
NCT06201676 Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma… Orthopaedic Trauma Recruiting
NCT06751992 Neurocognitive Function Changes With Extended-Release Tacrolimus Among Older Kidney… Kidney Transplant Recipients Recruiting
NCT06003153 GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at… Genetic Predisposition Recruiting
NCT07145866 Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine… Nicotine Dependence Recruiting
NCT06674109 SAVE-Care (Sodium Glucose Cotransporter-2 Inhibitors [SGLT2i] As Novel Gout Care) Trial Gout and Hyperuricemia Recruiting
NCT03623633 Comparative Antiresorptive Efficacy Discontinuation of Denosumab Osteoporosis, Postmenopausal Active, Not Recruiting
NCT03244020 LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic Oncology Sarcoma Enrolling by Invitation
NCT06433635 Sequential Multiple Assignment Randomized Trial for Bipolar Depression Bipolar I Disorder Active, Not Recruiting
NCT06436274 Efficacy of Human Papillomavirus (HPV) Vaccination to Prevent Infection Among Women… Human Papilloma Virus Active, Not Recruiting
NCT07439042 Buspirone for Anxiety in Autistic Youth Anxiety Not Yet Recruiting
NCT05010590 Anabolic Therapy in Postmenopausal Osteoporosis Postmenopausal Osteoporosis Active, Not Recruiting
NCT07535411 Bupivacaine Liposome Suspension Administration to Decreasre Peri-procedural Pain in… Analgesia Assessment Not Yet Recruiting
NCT07342452 Randomized Trial of Combination Treatment With Sofwave and Sculptra Skin Aging Not Yet Recruiting
NCT05850091 Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention… Coronary Artery Disease Active, Not Recruiting
See all 587 active Massachusetts General Hospital trials with filters →
Disease Areas
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