588 active trials 315 recruiting 8 Phase 3 63 disease areas 105 changes in 30 days
58 trials changed in the last 30 days: 0 stopped, 36 with notable changes, 22 with minor changes only.
Primary and study completion pushed from Nov 30, 2026 to Sep 30, 2028
Massachusetts General HospitalPhase 1 NCT04699747 Registry history of NCT04699747 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Jun 30, 2026 to Mar 31, 2027
Also in this update: Completion pushed from Sep 30, 2026 to Jun 30, 2027
Massachusetts General HospitalNot applicable NCT06541990 Registry history of NCT06541990 on ClinicalTrials.gov (opens the registry)
Updated
Primary and study completion pushed from Sep 2026 to Sep 2030
Massachusetts General HospitalNot specified NCT02118922 Registry history of NCT02118922 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Aug 31, 2026 to Sep 29, 2027
Also in this update: Enrollment closed, study ongoing; Completion pushed from Apr 15, 2027 to Sep 29, 2027
Massachusetts General HospitalNot applicable NCT07010978 Registry history of NCT07010978 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Sep 1, 2026 to Apr 1, 2027
Also in this update: Completion pushed from Sep 1, 2027 to Apr 1, 2029
Massachusetts General HospitalPhase 1 NCT06440135 Registry history of NCT06440135 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Jun 2026 to Jul 2028
Also in this update: Enrollment changed: None → 1200; Completion pushed from Sep 2026 to Jul 2028
Massachusetts General HospitalNot specified NCT01035398 Registry history of NCT01035398 on ClinicalTrials.gov (opens the registry)
Updated
Primary and study completion pushed from Sep 2026 to Sep 2028
Massachusetts General HospitalNot specified NCT03029325 Registry history of NCT03029325 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Aug 2026 to Aug 2028
Also in this update: Completion pushed from Dec 2026 to Dec 2028
Massachusetts General HospitalNot specified NCT00006496 Registry history of NCT00006496 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Sep 15, 2026 to Sep 15, 2028
Also in this update: Completion pushed from Oct 1, 2026 to Oct 1, 2028
Massachusetts General HospitalNot applicable NCT05486520 Registry history of NCT05486520 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Sep 10, 2026 to Oct 5, 2027
Also in this update: Completion pushed from Apr 10, 2027 to Oct 5, 2027
Massachusetts General HospitalNot applicable NCT05976490 Registry history of NCT05976490 on ClinicalTrials.gov (opens the registry)
Updated
Primary and study completion pushed from Sep 2026 to Sep 2028
Also in this update: Enrollment changed: None → 15000
Massachusetts General HospitalNot specified NCT00471978 Registry history of NCT00471978 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Dec 2026 to Dec 2028
Also in this update: Completion pushed from Dec 2028 to Dec 2030
Massachusetts General HospitalNot applicable NCT02202590 Registry history of NCT02202590 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Dec 30, 2026 to Dec 30, 2028
Also in this update: Completion pushed from Dec 30, 2027 to Dec 30, 2030
Massachusetts General HospitalNot applicable NCT03566160 Registry history of NCT03566160 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Dec 2028 to Dec 2031
Also in this update: Enrollment reopened; Completion pushed from Dec 2030 to Dec 2032
Massachusetts General HospitalPhase 1/2 NCT05900401 Registry history of NCT05900401 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Sep 2027 to Sep 2028
Also in this update: Completion pushed from Dec 2027 to Dec 2028
Massachusetts General HospitalPhase 4 NCT07145866 Registry history of NCT07145866 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Jan 2027 to Jan 2029
Also in this update: Completion pushed from Jun 2027 to Jun 2029
Massachusetts General HospitalPhase 1 NCT04540380 Registry history of NCT04540380 on ClinicalTrials.gov (opens the registry)
Updated
Primary and study completion pushed from Jun 30, 2026 to Dec 31, 2026
Also in this update: Enrollment closed, study ongoing
Massachusetts General HospitalNot applicable NCT05304286 Registry history of NCT05304286 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Jul 31, 2026 to Jul 31, 2029
Also in this update: Completion pushed from Oct 31, 2026 to Oct 31, 2029
Massachusetts General HospitalNot applicable NCT06009159 Registry history of NCT06009159 on ClinicalTrials.gov (opens the registry)
Updated
Primary and study completion pushed from Aug 31, 2026 to Aug 31, 2027
Massachusetts General HospitalNot specified NCT04916210 Registry history of NCT04916210 on ClinicalTrials.gov (opens the registry)
Updated
Primary endpoint(s) modified
Massachusetts General HospitalPhase 4 NCT07838311 Registry history of NCT07838311 on ClinicalTrials.gov (opens the registry)
Updated
Trial completed
Also in this update: Final enrollment: 13 participants (planned 20); Primary completion date changed from estimate of Sep 1, 2026 to Nov 6, 2025
Massachusetts General HospitalEarly Phase 1 NCT03748446 Registry history of NCT03748446 on ClinicalTrials.gov (opens the registry)
Updated
Trial completed
Massachusetts General HospitalNot applicable NCT07424443 Registry history of NCT07424443 on ClinicalTrials.gov (opens the registry)
Updated
Enrollment closed, study ongoing
Massachusetts General HospitalNot applicable NCT06298253 Registry history of NCT06298253 on ClinicalTrials.gov (opens the registry)
Updated
Trial completed
Also in this update: Final enrollment: 56 participants (planned 30); Study completion date changed from estimate of Aug 31, 2026 to Oct 1, 2026
Massachusetts General HospitalNot applicable NCT06172933 Registry history of NCT06172933 on ClinicalTrials.gov (opens the registry)
Updated
Trial completed
Also in this update: Final enrollment: 13 participants (planned 10); Primary completion date changed from estimate of Aug 1, 2026 to Apr 9, 2026
Massachusetts General HospitalNot applicable NCT06998498 Registry history of NCT06998498 on ClinicalTrials.gov (opens the registry)
Updated
Trial completed
Also in this update: Final enrollment: 6 participants (planned 30)
Massachusetts General HospitalNot applicable NCT06429293 Registry history of NCT06429293 on ClinicalTrials.gov (opens the registry)
Updated
Trial completed
Also in this update: Final enrollment: 6 participants (planned 5)
Massachusetts General HospitalNot applicable NCT06820242 Registry history of NCT06820242 on ClinicalTrials.gov (opens the registry)
Updated
Trial completed
Also in this update: Final enrollment: 20 participants (planned 30); Primary completion date changed from estimate of Jul 1, 2026 to Sep 2, 2026
Massachusetts General HospitalNot applicable NCT06754917 Registry history of NCT06754917 on ClinicalTrials.gov (opens the registry)
Updated
Enrollment closed, study ongoing
Massachusetts General HospitalPhase 2 NCT04560322 Registry history of NCT04560322 on ClinicalTrials.gov (opens the registry)
Updated
Trial completed
Massachusetts General HospitalPhase 3 NCT04964947 Registry history of NCT04964947 on ClinicalTrials.gov (opens the registry)
Updated
Trial completed
Massachusetts General HospitalPhase 3 NCT07269808 Registry history of NCT07269808 on ClinicalTrials.gov (opens the registry)
Updated
Trial completed
Also in this update: Final enrollment: 297 participants (planned 350); Primary completion date changed from estimate of Sep 30, 2026 to May 19, 2026
Massachusetts General HospitalNot applicable NCT05470920 Registry history of NCT05470920 on ClinicalTrials.gov (opens the registry)
Updated
Primary and study completion pushed from Sep 15, 2026 to Feb 15, 2027
Massachusetts General HospitalPhase 1 NCT02886065 Registry history of NCT02886065 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Aug 2026 to Dec 2026
Massachusetts General HospitalNot applicable NCT02792270 Registry history of NCT02792270 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Dec 31, 2027 to May 31, 2028
Also in this update: Completion pushed from Dec 31, 2028 to May 31, 2029
Massachusetts General HospitalNot applicable NCT05523817 Registry history of NCT05523817 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Aug 31, 2026 to Dec 31, 2026
Massachusetts General HospitalNot applicable NCT05923606 Registry history of NCT05923606 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Jan 2027 to Apr 2027
Also in this update: Completion pushed from Feb 2027 to Jul 2027
Massachusetts General HospitalNot applicable NCT07399873 Registry history of NCT07399873 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion pushed from Feb 2027 to Apr 2027
Also in this update: Completion pushed from Mar 2027 to Jun 2027
Massachusetts General HospitalNot applicable NCT07757880 Registry history of NCT07757880 on ClinicalTrials.gov (opens the registry)
Updated
Enrollment increased: 6080 → 7140 participants
Massachusetts General HospitalNot applicable NCT07166861 Registry history of NCT07166861 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion moved earlier from Dec 30, 2027 to Nov 2, 2027
Also in this update: Completion moved earlier from Apr 1, 2028 to Nov 19, 2027
Massachusetts General HospitalPhase 4 NCT06558188 Registry history of NCT06558188 on ClinicalTrials.gov (opens the registry)
Updated
Completion pushed from Apr 23, 2026 to Feb 23, 2028
Massachusetts General HospitalNot specified NCT03238755 Registry history of NCT03238755 on ClinicalTrials.gov (opens the registry)
Updated
Completion pushed from May 31, 2026 to Dec 31, 2026
Massachusetts General HospitalPhase 1 NCT03770429 Registry history of NCT03770429 on ClinicalTrials.gov (opens the registry)
Updated
| First posted | Trial | Phase | Status |
|---|---|---|---|
| 2026-10-09 | NCT07868588 Leveraging Interventions for Caregiver Growth, Health, Training, Empowerment and… | Not Yet Recruiting | |
| 2026-10-08 | NCT07866872 Blood Volume Monitoring Via Critline in Volume Overload: Hospitalization and Readmission | Enrolling by Invitation | |
| 2026-10-06 | NCT07860762 Augmenting Clinical Workflow With a Structured Chatbot for Patient History Collection and… | Not Yet Recruiting | |
| 2026-09-24 | NCT07838311 Delayed-Release, Extended-Release Methylphenidate (Jornay PM) for Adolescents and Young… | Phase 4 | Not Yet Recruiting |
| 2026-09-14 | NCT07819344 Molecular Imaging to Identify Predictors of Aortic Valve Disease Activity | Not Yet Recruiting |
| Early Phase 1 | 23 | |
| Phase 1 | 28 | |
| Phase 1/2 | 12 | |
| Phase 2 | 89 | |
| Phase 3 | 8 | |
| Phase 4 | 33 |
| NCT ID | Title | Condition | Status | Updated |
|---|---|---|---|---|
| Phase 4 | ||||
| NCT07683975 | Infliximab for Immune Checkpoint Inhibitor Associated AKI | Acute Kidney Injury | Recruiting | 2026-10-09 |
| NCT06558188 | Combined Anabolic Therapy | Osteoporosis, Postmenopausal | Recruiting | 2026-10-08 |
| NCT07010302 | Rituximab Versus Ravulizumab, Inebilizumab, Satralizumab, and Eculizumab in NMOSD | NMOSD | Recruiting | 2026-09-24 |
| NCT07439042 | Buspirone for Anxiety in Autistic Youth | Anxiety | Recruiting | 2026-09-17 |
| NCT07145866 | Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine… | Nicotine Dependence | Recruiting | 2026-09-15 |
| NCT07699445 | The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With… | Bipolar Depression Depressed Phase | Recruiting | 2026-09-11 |
| NCT06674109 | SAVE-Care (Sodium Glucose Cotransporter-2 Inhibitors [SGLT2i] As Novel Gout Care) Trial | Gout and Hyperuricemia | Recruiting | 2026-08-05 |
| NCT06003153 | GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at… | Genetic Predisposition | Recruiting | 2026-07-08 |
| NCT06751992 | Neurocognitive Function Changes With Extended-Release Tacrolimus Among Older Kidney… | Kidney Transplant Recipients | Recruiting | 2026-05-28 |
| NCT06201676 | Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma… | Orthopaedic Trauma | Recruiting | 2026-05-14 |
| NCT04400266 | Buspirone and Melatonin for Depression Following Traumatic Brain Injury | Depression | Recruiting | 2026-05-06 |
| NCT05853627 | Mismatch vs. Standard Intervention During Memory Reconsolidation Blockade With… | Stress Disorders, Post-Traumatic | Recruiting | 2026-05-06 |
| NCT07166939 | 45th Multicenter Airway Research Collaboration | Asthma Acute | Recruiting | 2026-04-17 |
| NCT07199335 | Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs | HIV | Recruiting | 2026-03-19 |
| NCT07346079 | Purified Cortrophin® Gel Efficacy and Safety Study of 2 Dose Levels in Patients With… | Gout Arthritis | Recruiting | 2026-01-20 |
| NCT07131592 | Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction… | Drain Output After Breast Reduction Surgery | Recruiting | 2026-01-16 |
| NCT05450432 | Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk… | Major Depressive Disorder | Recruiting | 2025-12-12 |
| NCT02283996 | Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of… | Adhesive Capsulitis | Recruiting | 2025-10-27 |
| NCT04875702 | Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout | Gout | Recruiting | 2025-09-25 |
| NCT03718403 | Effect of Theophylline in Pseudohypoparathyroidism | PHP Ia | Recruiting | 2022-07-22 |
| NCT03244020 | LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic Oncology | Sarcoma | Enrolling by Invitation | 2026-10-09 |
| NCT07342452 | Randomized Trial of Combination Treatment With Sofwave and Sculptra | Skin Aging | Not Yet Recruiting | 2026-10-06 |
| NCT07838311 | Delayed-Release, Extended-Release Methylphenidate (Jornay PM) for Adolescents and Young… | ADHD | Not Yet Recruiting | 2026-09-28 |
| NCT07739537 | PATHS-T2D: A Recall-by-Genotype Study of Physiologic and Pharmacologic Responses | Diabete Type 2 | Not Yet Recruiting | 2026-08-31 |
| NCT07729332 | Switching to Oral Weight Management Pharmacotherapy to Prevent Weight Regain After GLP-1… | Obesity | Not Yet Recruiting | 2026-07-27 |
Depression (41) · Lung Cancer (24) · Breast Cancer (22) · Anxiety (20) · Colorectal Cancer (18) · Obesity (17) · Leukemia (15) · Diabetes (13) · Multiple Myeloma (13) · Crohn's Disease (9)