Disease landscape

Colorectal Cancer clinical trials

Get alerts when Colorectal Cancer trials change

2,230 active trials 1,265 recruiting 205 Phase 3 985 sponsors 270 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 63 of 270 changes on 20 trials

2026-09-03
Withdrawn before enrolling
Trial withdrawn: Unable to finalize study agreements
NCT06929338 xDRIVE in Metastatic Colorectal Cancer · First Ascent Biomedical Inc.
2026-08-14
Trial terminated
Trial terminated: Following completion of Phase 1b, the Sponsor decided not to initiate Part 2 of the trial.
Primary endpoint(s) modified
Primary completion moved earlier: 2025-07 → 2025-04-30
Completion moved earlier: 2025-11 → 2025-04-30
NCT05572684 A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants… · NextCure, Inc. · Phase 1/2
2026-09-03
Trial status changed: Recruiting → Withdrawn
Trial withdrawn: Study was stopped Sponsor discretion. No patients were dosed.
NCT06487377 IX001 TCR-T In the Treatment of Advanced Pancreatic Cancer and Colorectal Cancer Induced… · Shanghai Pudong Hospital · Phase 1
2026-09-03
Trial terminated
Trial terminated: Terminated due to low accrual.
Final enrollment: 10 participants (planned 30)
Primary completion confirmed: June 2026 (last estimated January 2027)
NCT05930496 Evaluating the Effects of an Exercise Intervention on the Gut Microbiota in Stage II-III… · Fred Hutchinson Cancer Center
2026-09-05
Primary completion pushed: 2027-02 → 2029-06
Primary endpoint(s) modified
Enrollment increased: 495 → 575 participants
Interventions modified
Completion pushed: 2027-04 → 2029-06
Trial arms changed: 9 → 11
NCT06400472 A Study of Sofe-M in Participants With Selected Advanced Solid Tumors · Eli Lilly and Company · Phase 1
2026-09-04
Primary completion pushed: 2026-04 → 2026-12
Enrollment closed, study ongoing
Completion pushed: 2026-04 → 2026-12
NCT06337084 Diagnostic Efficacy and Dosimetry of MNPR-101-DFO*-89Zr in Patients With Solid Tumors · Monopar Therapeutics · Phase 1
2026-08-14
Primary completion pushed: 2026-03 → 2027-03
Completion pushed: 2026-03 → 2027-03
NCT05288205 Phase 1/2a Study of JAB-21822 Plus JAB-3312 in Patients With Advanced Solid Tumors… · Allist Pharmaceuticals, Inc. · Phase 1/2
2026-08-12
Primary completion pushed: 2026-10 → 2027-09
Trial sites reduced: 32 → 19 locations
Completion pushed: 2026-10 → 2027-09
NCT05592626 A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion… · Marengo Therapeutics, Inc. · Phase 1/2
2026-08-12
Primary completion pushed: 2025-06-30 → 2026-12-30
Sponsor changed: Evopoint Biosciences Inc. → Astellas Pharma Global Development, Inc.
Enrollment closed, study ongoing
Completion pushed: 2025-12-31 → 2027-06-30
NCT06792435 XNW27011 Study of Advanced Solid Tumor Subjects Who Failed Standard Therapies. · Astellas Pharma Global Development, Inc. · Phase 1/2
2026-09-03
Primary completion pushed: 2028-12-30 → 2030-12-30
Primary endpoint(s) modified
Phase changed: Phase 1 → Phase 1/2
Enrollment increased: 124 → 280 participants
Interventions modified
Trial sites expanded: 7 → 10 locations
Completion pushed: 2029-12-30 → 2031-12-30
Trial arms changed: 2 → 3
NCT05868226 PRE-ISPY Phase I/II Oncology Platform Program · QuantumLeap Healthcare Collaborative · Phase 1/2
2026-09-02
Primary completion pushed: 2025-05-10 → 2026-04-08
Completion pushed: 2026-08-25 → 2026-12-01
NCT05672316 Botensilimab, Balstilimab and Regorafenib for the Treatment of Patients With… · City of Hope Medical Center · Phase 1/2
2026-09-02
Primary completion pushed: 2026-06-23 → 2027-06-16
Completion pushed: 2026-06-23 → 2027-06-16
NCT05627635 FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for… · City of Hope Medical Center · Phase 1/2
2026-09-04
Primary completion pushed: 2025-11 → 2026-11
Completion pushed: 2025-12 → 2026-12
NCT07158203 Optical Diagnosis of Neoplasia Using Artificial Intelligence · Fundacin Biomedica Galicia Sur
2026-08-22
Primary completion pushed: 2028-02 → 2028-12
Recruitment opened
Trial sites expanded: 2 → 9 locations
Completion pushed: 2028-02 → 2028-12
NCT07429110 ColoSeal™ ICD System Anastomotic Protection Pivotal Study · Averto Medical, Inc.
2026-08-28
Primary completion pushed: 2028-08-31 → 2028-12-31
Completion moved earlier: 2029-11-30 → 2029-06-30
NCT07224022 Cemiplimab With Fianlimab for Resectable Non-Metastatic Colon Cancer · John Strickler, M.D. · Phase 2
2026-09-03
Primary endpoint(s) modified
Trial completed
Primary completion confirmed: June 2026 (last estimated June 2027)
NCT05864144 A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in… · Sensei Biotherapeutics, Inc. · Phase 1/2
2026-08-18
Primary completion pushed: 2023-09-15 → 2026-09-15
NCT04246684 Short RT Versus RCT,Followed by Chemo and Organ Preservation for Interm and High-risk… · Prof. Dr. med. Claus Rödel · Phase 3
2026-08-28
Primary completion pushed: 2026-10-02 → 2028-02-13
Enrollment reopened
Enrollment increased: 33 → 51 participants
Completion pushed: 2026-12-20 → 2028-02-13
NCT04589468 Researching the Effect of Exercise on Cancer · City of Hope Medical Center
2026-08-22
Primary completion pushed: 2026-08-01 → 2027-08-01
Completion pushed: 2026-10-01 → 2027-10-01
NCT05148494 TES RCT Fleet Enema vs Oral Mechanical Bowel Prep · Nova Scotia Health Authority · Phase 4
2026-08-14
Primary completion pushed: 2026-07-20 → 2027-07-05
Completion pushed: 2026-07-20 → 2027-07-05
NCT05722288 Time-Restricted Eating Versus Nutritional Counseling for the Reduction of Radiation or… · City of Hope Medical Center · Phase 2

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-04 NCT07805369 A Phase 1 Study of DEM301 in Participants With Metastatic Colorectal Cancer DEM BioPharma, Inc. new Phase 1
2026-09-01 NCT07797361 Evaluation of Versatile Intelligent Staining Technology (VIST) and Spectral Flexible… Alexandre Vontobel Padoin new
2026-08-27 NCT07790510 HSK42360-Na Tablets Combined With Cetuximab With or Without Chemotherapy in BRAF… Haisco Pharmaceutical Group Co., Ltd. new Phase 1/2
2026-08-26 NCT07788729 Social Prescriptions and Micro-Learning to Improve Care for Cancer Patients and Their… University of Regensburg new
2026-08-25 NCT07784114 Incremental Value of Traditional Chinese Medicine Features in Two-Stage Pre-Endoscopic… Beijing University of Chinese Medicine new
2026-08-24 NCT07781306 PrOspEctive Metastases Imaging (POEM) Cancer Research Antwerp new
2026-08-24 NCT07781852 Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and… Lumina Pharmaceuticals Inc new Early Phase 1
2026-08-21 NCT07780305 ABCSG R07 Rectal Cancer Registry Austrian Breast & Colorectal Cancer Study Group new
2026-08-21 NCT07778875 Self-Reported Colorectal Cancer Screening Uptake Bartın Unıversity new
2026-08-14 NCT07766044 A One-year Follow-up of Incisional Hernia Formation Between Device Assisted and Manual… Suturion AB new

Active trials by phase

Early Phase 1
28
Phase 1
202
Phase 1/2
181
Phase 2
517
Phase 2/3
38
Phase 3
167
Phase 4
23
Not charted: 1,074 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 2,230

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT05148494 TES RCT Fleet Enema vs Oral Mechanical Bowel Prep Nova Scotia Health Authority Recruiting 2026-08-21
NCT07696793 Efficacy and Tolerability of a Simethicone-containing Evacuating Solution for Colorectal… Fundacion Clinic per a la Recerca Biomédica Recruiting 2026-07-10
NCT06562543 A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With… Takeda Recruiting 2026-07-07
NCT07209787 SIS-Reinforced vs. Conventional Anastomosis for Mid-to-Low Rectal Cancer: A Multicenter… Beijing Chao Yang Hospital Recruiting 2026-06-17
NCT05726136 Fluid Challenge and Plasma Volume, During Surgery Joachim Zdolsek Recruiting 2026-04-30
NCT07158164 DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment Rutgers, The State University of New Jersey Recruiting 2025-11-13
NCT07215000 Cleansing Options in Out-Patient Setting to Improve Tolerance (COOP SIT) Trial Morehouse School of Medicine Recruiting 2025-10-09
NCT06090994 Prevention of Recurrence and Metastasis of Colorectal Cancer by Comparing Huaier With… Fudan University Recruiting 2025-05-07
NCT06550453 Safety and Efficacy of Pembrolizumab in Combination with Bevacizumab + CapeOX in the… yangjianjun Recruiting 2024-11-12
NCT05250648 Clinical Trial on HIPEC With Mitomycin C in Colon Cancer Peritoneal Metastases (GECOP-MMC) Hospital Universitario de Fuenlabrada Recruiting 2024-10-09
NCT06118762 Clinical Study of Fruquintinib Combined With Raltitrexed in the Treatment of Metastatic… The First Affiliated Hospital of Nanchang University Recruiting 2023-11-07
NCT05148767 UGT1A1-Based Irinotecan Therapy for Locally Advanced Rectal Cancer Zhejiang Cancer Hospital Recruiting 2021-12-08
NCT07802847 Innovative and Cooperative Pathway Integrating Oncogeriatric, Pharmaceutical and… Gustave Roussy, Cancer Campus, Grand Paris Not Yet Recruiting 2026-09-03
NCT07768358 Tucatinib Continuation Study Pfizer Not Yet Recruiting 2026-08-28
NCT07094893 Anti-EGFR Agents in Patients With Right-sided Advanced Colorectal Cancer With Wild-type… Gruppo Oncologico del Nord-Ovest Not Yet Recruiting 2026-07-24
NCT07624916 Transversus Abdominis Plane and Rectus Sheath Block for Robotic Colectomy Tri-Service General Hospital Not Yet Recruiting 2026-06-03
NCT07483060 Next Generation STAR-TREC (NG-ST) - Organ Preservation in Early Rectal Cancer Vastra Gotaland Region Not Yet Recruiting 2026-03-19
NCT07446465 FOLFOX Chemotherapy Combined With Fruquintinib and Serplulimab as First-Line Conversion… Ye Xu Not Yet Recruiting 2026-03-03
NCT07152886 The Effects of Clostridium Butyricum on Adverse Events During Adjuvant Chemotherapy for… The Affiliated Hospital of Qingdao University Not Yet Recruiting 2025-09-03
NCT07020468 Neoadjuvant Therapy （NALIRIFOX） for Locally Advanced Colon and Upper Rectal Cancer Affiliated Cancer Hospital of Shantou University Medical College Active, Not Recruiting 2025-06-13
NCT06881563 Intrathecal Morphine Versus Epidural Analgesia for Laparoscopic Colon Surgery Meri Mirceta Not Yet Recruiting 2025-03-18
NCT06665334 To Explore the Effect of Huaier Granule on the Negative Conversion Rate After the CEA… Fudan University Not Yet Recruiting 2024-10-31
NCT04281667 Mechanical Bowel Preparation and Oral Antibiotics Versus Mechanical Bowel Preparation… Helsinki University Central Hospital Active, Not Recruiting 2022-11-17
Phase 3
NCT06252649 Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without… Amgen Recruiting 2026-09-03
NCT07228832 Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With… Summit Therapeutics Recruiting 2026-09-02
See all 2,230 active Colorectal Cancer trials with filters →

Top sponsors by active trials in this area

Fudan University (75) · Sun Yat-sen University (66) · M.D. Anderson Cancer Center (45) · National Cancer Institute (NCI) (34) · City of Hope Medical Center (27) · Memorial Sloan Kettering Cancer Center (25) · Sixth Affiliated Hospital, Sun Yat-sen University (24) · Peking University Cancer Hospital & Institute (18) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (18) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (17)

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