Also listed under Colonic Diseases, Rectal Diseases

ClinicalTrials.gov term: Colorectal Neoplasms

Disease landscape

Colorectal Cancer clinical trials

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Data updated daily from ClinicalTrials.gov, last refresh 2026-10-20

What changed in the last 30 days

202 trials changed in the last 30 days: 5 stopped, 88 with notable changes, 109 with minor changes only.

  1. Notable

    iPULSAR-CRC · Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR ) Combined With Anti-PD1,Chemotherapy and Target Therapy for Metastatic Colorectal Cancer

    Primary completion pushed from Mar 1, 2026 to Sep 30, 2029

    Also in this update: Study completion pushed from Mar 1, 2028 to Sep 30, 2030

    Fudan UniversityPhase 2 NCT06841159 Registry history of NCT06841159 on ClinicalTrials.gov (opens the registry)

Show 109 trials with minor changes only
  1. Minor

    M3-PRO · Diagnostic Accuracy of a Panel of Bacterial Gene Markers (M3) for Colorectal Advanced Neoplasia

    Trial status changed: Unknown → Active, Not Recruiting

    Also in this update: Study completion pushed from Dec 31, 2025 to Dec 31, 2030; Primary completion date changed from estimate of Jun 15, 2025 to May 7, 2025

    Chinese University of Hong KongNot specified NCT05405673 Registry history of NCT05405673 on ClinicalTrials.gov (opens the registry)

  2. Minor

    AndroMETa-CRC · Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab · Metastatic Colorectal Cancer

    Trial sites expanded: 78 → 81 locations

    And 1 more change in the last 30 days

    AbbViePhase 2 NCT06820463 Registry history of NCT06820463 on ClinicalTrials.gov (opens the registry)

  3. Minor

    AndroMETa-CRC · Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil · Refractory Metastatic Colorectal Cancer

    Trial sites expanded: 84 → 87 locations

    And 1 more change in the last 30 days

    AbbViePhase 3 NCT07525206 Registry history of NCT07525206 on ClinicalTrials.gov (opens the registry)

  4. Minor

    Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or Targeted Therapy and/or ICI, · Advanced Gastrointestinal Cancers, Including Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)

    Enrollment increased: 258 → 350 participants

    Also in this update: Interventions modified

    Phanes TherapeuticsPhase 1/2 NCT05482893 Registry history of NCT05482893 on ClinicalTrials.gov (opens the registry)

  5. Minor
    28 trials marked Unknown by the registry's verification sweep
    1. Minor

      Development and Demonstration of Intelligent Assessment Based on Multi-modal Information Fusion for Tumor Risk and Diagnosis and Treatment

      Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Recruiting

      Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyNot specified NCT06653478 Registry history of NCT06653478 on ClinicalTrials.gov (opens the registry)

      Changed

    Registry verification sweep

    Changed

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-10-16 NCT07878988 This is a Phase 1/1b Study to Evaluate the Safety and Preliminary Antitumor Activity of… LTZ Therapeutics, Inc. new Phase 1
2026-10-15 NCT07874880 MTX-531-001 Phase 1 Study in Advanced Solid Tumors MEKanistic Therapeutics, Inc. new Phase 1
2026-10-15 NCT07875920 Phase 1 Study of NW-301V TCR-T Cells in Advanced Solid Tumors With KRAS G12V Mutation Neowise Biotechnology new Phase 1
2026-10-15 NCT07875465 Intestinal Low-Dose Radiotherapy Combined With Immune Checkpoint Inhibitors in Solid… Bing Xia new Phase 2
2026-10-14 NCT07874035 Low Load Blood Flow Restriction Resistance Training in Colorectal Cancer Related… Ahmed Adel Ahmed Elsayed Ali Radwan new
2026-10-14 NCT07873450 SumMET: Study of [225Ac]Ac-FL-261 in Participants With Solid Tumors Overexpressing c-MET Full-Life Technologies UK Limited new Phase 1/2
2026-10-07 NCT07863154 Probiotic Supplementation During Neoadjuvant Chemoradiotherapy in Colorectal Cancer University of Malaga new
2026-09-30 NCT07850778 ONS USE IN COLON CANCER Osmaniye Korkut Ata University new
2026-09-30 NCT07850882 A Prospective Real-World Observational Study of Intratumoral Oncolytic Virus Injection… Jie Yuan,MD new
2026-09-28 NCT07844187 TQB2922 Injection Given Under the Skin With Chemotherapy as Initial Treatment for… Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd. new Phase 1/2

Active trials by phase

Early Phase 1
33
Phase 1
278
Phase 1/2
215
Phase 2
608
Phase 2/3
45
Phase 3
189
Phase 4
27
Not charted: 1,375 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Top sponsors by active trials in this area

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Active trials