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National Cancer Institute (NCI) clinical trial pipeline

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781 active trials 293 recruiting 97 Phase 3 10 disease areas 142 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 43 of 142 changes on 20 trials

2026-08-28
Withdrawn before enrolling
Trial withdrawn: Other - Protocol moved to Withdrawn
Enrollment reduced: 24 → 0 participants
NCT06982222 Testing the Safety of the Anti-cancer Drug, Sn-117m-DTPA, for Advanced Cancers That Have… · Phase 1
2026-08-28
Recruitment suspended
Recruitment suspended: Unacceptable Toxicity
NCT03816319 TAK-243 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or… · Phase 1
2026-08-15
Recruitment suspended
Recruitment suspended: Other - Extend the observation period for current patients
NCT05691478 A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With… · Phase 2/3
2026-08-15
Recruitment suspended
Recruitment suspended: Placed on voluntary hold to new recruitment pending modification to combination monoclonal antibody treatment.
NCT06694454 Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab… · Phase 1/2
2026-08-14
Trial status changed: Completed → Terminated
Trial terminated: Accrual and drug manufacturing and supply were discontinued in 2025.
NCT02769962 Trial of EP0057, a Nanoparticle Camptothecin With Olaparib in People With… · Phase 1/2
2026-07-30
Recruitment suspended
Recruitment suspended: On hold pending consideration of an amendment to increase recruitment.
NCT04808427 Pilot Study to Investigate Magnetic Resonance (MR) Image Guided Focal Therapy in Prostate…
2026-08-27
Primary completion pushed: 2028-12-31 → 2029-10-31
Completion pushed: 2029-12-31 → 2030-10-31
NCT07349641 A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to… · Phase 2
2026-08-25
Primary completion pushed: 2026-09-01 → 2027-06-01
Completion pushed: 2026-09-01 → 2027-06-01
NCT04310020 Study of Radiation Therapy Followed by Atezolizumab in Stage II or III Non-small Cell… · Phase 2
2026-08-25
Primary completion pushed: 2026-08-31 → 2027-02-01
Completion pushed: 2026-08-31 → 2027-02-01
NCT05554380 Study of Chemotherapy Plus Ipatasertib for People With Solid Tumors With PTEN/AKT… · Phase 2
2026-08-22
Primary completion pushed: 2026-08-26 → 2028-08-26
Completion pushed: 2026-08-26 → 2028-08-26
NCT05554367 Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial · Phase 2
2026-08-20
Primary completion pushed: 2026-08-31 → 2027-08-31
Completion pushed: 2026-08-31 → 2027-08-31
NCT05600894 Venetoclax in Combination With ASTX727 for the Treatment of Chronic Myelomonocytic… · Phase 2
2026-08-22
Primary completion pushed: 2026-08-31 → 2027-08-31
Completion pushed: 2026-08-31 → 2027-08-31
NCT05687136 Testing the Combination of Two Anti-cancer Drugs, Peposertib (M3814) and Tuvusertib… · Phase 1
2026-08-19
Primary completion pushed: 2026-12-31 → 2027-03-31
Completion pushed: 2026-12-31 → 2027-03-31
NCT06064097 A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal… · Phase 2
2026-08-14
Primary completion pushed: 2026-08-20 → 2027-08-01
Completion pushed: 2026-08-20 → 2027-08-01
NCT05001880 Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma · Phase 2
2026-08-14
Primary completion pushed: 2026-08-01 → 2029-08-01
Completion pushed: 2026-08-01 → 2029-08-01
NCT05419024 Imaging and Biopsy of People With HIV-1 Undergoing Analytic Treatment Interruption · Phase 2
2026-08-12
Primary completion pushed: 2026-07-31 → 2026-12-31
Completion pushed: 2026-12-31 → 2027-07-01
NCT04417660 Bintrafusp Alfa (M7824) in Subjects With Thymoma and Thymic Carcinoma · Phase 2
2026-08-12
Primary completion pushed: 2018-02-10 → 2021-09-09
Trial completed
Completion moved earlier: 2027-03-04 → 2021-09-09
NCT02581930 Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanoma · Phase 2
2026-08-12
Primary completion pushed: 2026-08-01 → 2027-08-01
Completion pushed: 2026-12-01 → 2027-12-01
NCT05361798 A Phase II Study Evaluating T-Cell Clonality After Stereotactic Body Radiation Therapy… · Phase 2
2026-08-12
Primary completion pushed: 2026-07-30 → 2027-07-30
Completion pushed: 2027-07-30 → 2028-07-30
NCT05470491 Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Allogeneic Hematopoietic Cell… · Phase 1/2
2026-08-07
Primary completion pushed: 2026-08-31 → 2029-03-31
Recruitment opened
Completion pushed: 2026-08-31 → 2029-03-31
NCT07463807 Testing the Investigational Medication Combination of Teclistamab and Pomalidomide… · Phase 1/2

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-08-11 NCT07756840 Combination Bevacizumab and PRGN-2012 in Adults With Recurrent Respiratory Papillomatosis… Phase 2 Not Yet Recruiting

Active trials by phase

Early Phase 1
1
Phase 1
162
Phase 1/2
79
Phase 2
314
Phase 2/3
17
Phase 3
80
Phase 4
2
Not charted: 126 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 781

NCT IDTitleConditionStatusUpdated
Phase 4
NCT05237947 Single-Dose HPV Vaccination for the Prevention of Cervical Cancer in Young Adult Women in… Human Papillomavirus-Related Cervical Carcinoma Active, Not Recruiting 2026-06-30
NCT03180034 Comparing One or Two Doses of the Human Papillomavirus Vaccine for the Prevention of… Human Papillomavirus Infection Active, Not Recruiting 2025-09-04
Phase 3
NCT04267848 Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy… Lung Non-Small Cell Carcinoma Recruiting 2026-08-27
NCT04269902 Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or… Chronic Lymphocytic Leukemia Recruiting 2026-08-27
NCT06058377 Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment… Anatomic Stage II Breast Cancer AJCC v8 Recruiting 2026-08-27
NCT06096844 Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With… Advanced Lung Non-Small Cell Carcinoma Recruiting 2026-08-27
NCT06337318 Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden… Classic Follicular Lymphoma Recruiting 2026-08-27
NCT06422806 Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for… Metastatic Dedifferentiated Liposarcoma Recruiting 2026-08-27
NCT07061977 Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation… Locally Advanced Cervical Adenocarcinoma Recruiting 2026-08-27
NCT05256225 Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2… Endometrial Carcinoma Recruiting 2026-08-26
NCT06524544 A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitecan-hziy Versus… Locally Advanced Urothelial Carcinoma Recruiting 2026-08-26
NCT04181060 Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With… Advanced Lung Non-Squamous Non-Small Cell Carcinoma Recruiting 2026-08-25
NCT05675410 A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs… Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8 Recruiting 2026-08-25
NCT06172296 Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of… Ganglioneuroblastoma, Nodular Recruiting 2026-08-25
NCT07198074 Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin… Advanced Endometrial Carcinoma Recruiting 2026-08-25
NCT07388524 Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early… Lung Non-Small Cell Carcinoma Recruiting 2026-08-25
NCT04166409 A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With… Low Grade Astrocytoma Recruiting 2026-08-24
NCT07391774 Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed… Anatomic Stage II Breast Cancer AJCC v8 Recruiting 2026-08-24
NCT06498635 Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard… Lung Non-Small Cell Carcinoma Recruiting 2026-08-21
NCT06589804 Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment… Metastatic Head and Neck Squamous Cell Carcinoma Recruiting 2026-08-05
NCT00602641 Melphalan, Prednisone, and Thalidomide or Lenalidomide in Treating Patients With Newly… Multiple Myeloma Active, Not Recruiting 2026-08-27
NCT01274338 Ipilimumab or High-Dose Interferon Alfa-2b in Treating Patients With High-Risk Stage… Melanoma of Unknown Primary Active, Not Recruiting 2026-08-27
NCT03811002 Testing the Addition of a New Immunotherapy Drug, Atezolizumab (MPDL3280A), to the Usual… Limited Stage Lung Small Cell Carcinoma Active, Not Recruiting 2026-08-27
NCT00114101 Lenalidomide in Treating Patients With Multiple Myeloma Undergoing Autologous Stem Cell… DS Stage I Multiple Myeloma Active, Not Recruiting 2026-08-26
NCT00433511 Doxorubicin Hydrochloride, Cyclophosphamide, and Paclitaxel With or Without Bevacizumab… Breast Adenocarcinoma Active, Not Recruiting 2026-08-26
See all 781 active National Cancer Institute (NCI) trials with filters →

Disease areas by active trials

Leukemia (89) · Sarcoma (67) · Lung Cancer (57) · Breast Cancer (55) · Multiple Myeloma (50) · Ovarian Cancer (43) · Non-Small Cell Lung Cancer (NSCLC) (41) · Melanoma (39) · Prostate Cancer (37) · Glioma (36)

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