Disease landscape

Head & Neck Cancer clinical trials

Get alerts when Head & Neck Cancer trials change

1,088 active trials 627 recruiting 73 Phase 3 540 sponsors 169 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 59 of 169 changes on 20 trials

2026-09-03
Trial terminated
Trial terminated: The study is being discontinued solely based on financial constraints and is not related to the safety of study partici...
Final enrollment: 12 participants — 5% of the 252 planned
Primary completion confirmed: August 2026 (last estimated February 2029)
NCT06790966 Phase 3 Study of PDS0101 and Pembrolizumab in HPV16+ Recurrent/Metastatic Head and Neck… · PDS Biotechnology Corp. · Phase 3
2026-08-14
Trial terminated
Trial terminated: Following completion of Phase 1b, the Sponsor decided not to initiate Part 2 of the trial.
Primary endpoint(s) modified
Primary completion moved earlier: 2025-07 → 2025-04-30
Completion moved earlier: 2025-11 → 2025-04-30
NCT05572684 A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants… · NextCure, Inc. · Phase 1/2
2026-09-01
Trial status changed: Recruiting → Withdrawn
Trial withdrawn: Poor accrual
Primary completion confirmed: June 2026 (last estimated August 2031)
NCT06990737 Phase 2 Pragmatic Trial of Sentinel Lymph Node Biopsy (SLNB) in Patients With Clinically… · University of California, Davis · Phase 2
2026-08-18
Withdrawn before enrolling
Trial withdrawn: logistical issues
Enrollment reduced: 60 → 0 participants
Sponsor changed: Stanford University → Andrei Iagaru
NCT05423197 89Zr-Panitumumab for Assessment of Suspected Metastatic Lesions on 18F-FDG-PET/CT in HNSCC · Andrei Iagaru · Phase 2
2026-09-04
Primary completion pushed: 2026-08 → 2027-03
Final enrollment: 39 participants (planned 100)
Completion pushed: 2026-08 → 2027-03
NCT06727565 Study of Novel Treatment Combination Therapies in Participants With Head and Neck… · Gilead Sciences · Phase 2
2026-09-03
Primary completion pushed: 2027-06 → 2027-12
Completion pushed: 2027-06 → 2027-12
NCT06959082 Efficacy and Safety Evaluation of VS-101 in Combination With Chemoradiotherapy in… · VSPharmTech Co.,Ltd. · Phase 2
2026-08-27
Primary completion pushed: 2027-09 → 2029-01
Primary endpoint(s) modified
Enrollment increased: 51 → 110 participants
Trial sites reduced: 17 → 12 locations
Completion pushed: 2028-01 → 2030-12
NCT06016920 Safety and Efficacy of VB10.16 and Pembrolizumab in Patients With Head-Neck Squamous Cell… · Nykode Therapeutics ASA · Phase 1/2
2026-08-27
Primary completion pushed: 2025-12 → 2026-12
Completion pushed: 2025-12 → 2026-12
NCT05054439 A Clinical Study of SI-B001 in Combination With Paclitaxel/Docetaxel in the Treatment of… · Sichuan Baili Pharmaceutical Co., Ltd. · Phase 2
2026-09-04
Primary completion pushed: 2030-09-30 → 2031-09-30
Completion pushed: 2030-09-30 → 2031-09-30
NCT07509099 Cetuximab Combined With Pembrolizumab or Finotonlimab and Chemotherapy in R/M HNSCC · Ji Dongmei · Phase 3
2026-08-08
Primary completion pushed: 2026-10 → 2027-03
Phase changed: Phase 1 → Phase 1/2
Enrollment increased: 136 → 208 participants
Completion pushed: 2027-03 → 2027-09
Trial arms changed: 6 → 9
NCT06515990 A Study of DM005 in Patients With Advanced Solid Tumors · Doma Biopharmaceutical（Suzhou）Co., Ltd. · Phase 1/2
2026-09-05
Primary completion pushed: 2026-08-31 → 2027-08-31
Completion pushed: 2026-08-31 → 2027-08-31
NCT06125743 Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial] · Abramson Cancer Center at Penn Medicine
2026-08-29
Primary completion pushed: 2026-05-15 → 2026-09-30
Primary endpoint(s) modified
Completion pushed: 2026-05-15 → 2026-09-30
NCT02270814 Cisplatin, Nab-Paclitaxel, and Cetuximab (CACTUX) in Patients With Incurable Head and… · Washington University School of Medicine · Phase 2
2026-08-25
Primary completion pushed: 2027-12 → 2028-12
Completion pushed: 2029-12 → 2030-12
NCT04178174 Stereotactic Boost and Short-course Radiation Therapy for Oropharynx Cancer · Centre hospitalier de l'Université de Montréal (CHUM) · Phase 3
2026-08-28
Primary completion pushed: 2026-02-28 → 2026-08-31
Enrollment reduced: 20 → 14 participants
Trial status changed: Enrolling by Invitation → Active, Not Recruiting
Completion pushed: 2026-02-28 → 2026-10-31
NCT05937269 Assessing Impact of Early Physiotherapy on Lymphatic Dysfunction in Head and Neck Cancer… · The University of Texas Health Science Center, Houston · Phase 1
2026-09-03
Primary endpoint(s) modified
Trial completed
Primary completion confirmed: June 2026 (last estimated June 2027)
NCT05864144 A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in… · Sensei Biotherapeutics, Inc. · Phase 1/2
2026-08-21
Primary completion pushed: 2026-06-01 → 2026-12-01
NCT06998069 Head and Neck Cancer Study Project in the Geriatric Population · Brown University · Phase 3
2026-08-20
Primary completion pushed: 2026-08-01 → 2026-11-01
Trial status changed: Not Yet Recruiting → Active, Not Recruiting
Enrollment increased: 10 → 20 participants
Trial arms changed: 1 → 2
NCT06508606 AK117 (Anti-CD47 mAb) Plus Cetuximab or AK104 (Anti-PD-1/CTLA-4 bsAb) as Second-Line… · West China Hospital · Phase 2
2026-08-19
Primary completion pushed: 2026-07-31 → 2026-12-31
Completion pushed: 2027-01-31 → 2027-03-31
NCT06239220 PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC · Dana-Farber Cancer Institute · Phase 2
2026-08-14
Primary completion pushed: 2028-08-31 → 2028-11-30
Completion pushed: 2033-08-31 → 2033-11-30
NCT07552558 Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and… · Washington University School of Medicine · Phase 1/2
2026-08-11
Primary completion pushed: 2025-05-23 → 2026-11-25
NCT02955290 CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced… · Roswell Park Cancer Institute · Phase 1/2

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-31 NCT07796126 Sequential Toripalimab and Paclitaxel in Patients With Head and Neck Squamous Cell Cancer… Barbara Ann Karmanos Cancer Institute new Phase 2
2026-08-31 NCT07795294 Swallowing Rehabilitation Program for Head and Neck Tumor Patients Delta University for Science and Technology new
2026-08-31 NCT07795034 To Evaluate the Efficacy and Safety of Accelerator-Based Boron Neutron Capture Therapy… Neuboron Bio-SciTech Co., Ltd. new Phase 2
2026-08-28 NCT07791745 A Clinical Trial Comparing the Efficacy and Safety of Anyouping® and Platinum-based… Taizhou Mabtech Pharmaceutical Co.,Ltd new Phase 2/3
2026-08-24 NCT07781072 Sintilimab Plus Hypofractionated Radiotherapy Followed by Chemoradiotherapy for Locally… Second Affiliated Hospital, Zhejiang University, School of Medicine new Phase 2
2026-08-19 NCT07772063 Immunomonitoring of Circulating Immune Cells in Maxillofacial Surgery Assistance Publique - Hôpitaux de Paris new
2026-08-18 NCT07770100 Concurrent Immunotherapy and Systemic Therapy With Stereotactic Body Radiation Therapy… Mark Bernard new Phase 2
2026-08-12 NCT07759193 Energy Expenditure Assessment in Head and Neck Cancer Patients Treated With Free Flap… Tel-Aviv Sourasky Medical Center new
2026-08-11 NCT07756684 Feasibility of Cough Skill Training in Individuals With Head and Neck Cancer Boston University Charles River Campus new
2026-08-10 NCT07755449 CLEAR (Cervical Lymphatic Exclusion in Adjuvant Radiation) Institut Català d'Oncologia new Phase 2

Active trials by phase

Early Phase 1
21
Phase 1
157
Phase 1/2
107
Phase 2
307
Phase 2/3
13
Phase 3
60
Phase 4
9
Not charted: 414 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 1,088

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07405086 Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or… OHSU Knight Cancer Institute Recruiting 2026-06-12
NCT06162377 Methylnatrexone In Resectable Head and Neck Squamous Cell Carcinoma (MINK). A "Window of… M.D. Anderson Cancer Center Recruiting 2026-06-10
NCT07158164 DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment Rutgers, The State University of New Jersey Recruiting 2025-11-13
NCT07189897 Apixaban or Enoxaparin After Head and Neck Cancer Surgery Kiranya Arnold Recruiting 2025-10-08
NCT06734598 Efficacy of Botox Injection of the Masticatory Muscles in Head &Neck Cancer Patients with… National Taiwan University Hospital Recruiting 2024-12-16
NCT07635420 Comparing Intraoperative Indocyanine Green Fluorescence Imaging With Standard Clinical… Region Skane Not Yet Recruiting 2026-06-09
NCT07633613 Pharmacokinetic Study of Pembrolizumab and Its Impact on Immunity and the Tumor… Centre Antoine Lacassagne Not Yet Recruiting 2026-06-08
NCT06879691 A Trial of Nimotuzumab and Pinkiller Efficacy and Pain in Advanced Head and Neck Squamous… Biotech Pharmaceutical Co., Ltd. Active, Not Recruiting 2025-03-17
NCT06807034 Impact of the Oral Microbiota on Relapse in HNSCC Patients Institut Sainte Catherine Active, Not Recruiting 2025-02-04
Phase 3
NCT05751512 A Study to Evaluate MRG003 vs Cetuximab/Methotrexate in in the Treatment of Patients With… Lepu Biopharma Co., Ltd. Recruiting 2026-09-04
NCT06129864 A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally… AstraZeneca Recruiting 2026-09-03
NCT06589804 Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment… National Cancer Institute (NCI) Recruiting 2026-09-03
NCT07276399 A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC… Janssen Research & Development, LLC Recruiting 2026-08-28
NCT04178174 Stereotactic Boost and Short-course Radiation Therapy for Oropharynx Cancer Centre hospitalier de l'Université de Montréal (CHUM) Recruiting 2026-08-24
NCT06998069 Head and Neck Cancer Study Project in the Geriatric Population Brown University Recruiting 2026-08-20
NCT07441681 Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and… NRG Oncology Recruiting 2026-08-17
NCT04747054 Study on the Efficacy of Treatment by Radiotherapy and Pembrolizumab in Newly Diagnosed… UNICANCER Recruiting 2026-07-31
NCT07026474 Re-Radiochemotherapy and Pembrolizumab vs. Immuno(Chemo)Therapy for Locoregionally… Universität des Saarlandes Recruiting 2026-07-23
NCT06641791 Palliative Steroeotactic Body Radiotherapy vs Palliative Standard Radiotherapy in… Canadian Cancer Trials Group Recruiting 2026-07-14
NCT07672236 A Clinical Study to Compare BupiZenge With Lidocaine for Pain Due to Oral Mucositis in… OncoZenge AB Recruiting 2026-07-13
NCT06525220 A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in… Merus B.V. Recruiting 2026-06-02
NCT05815927 Pembrolizumab and Radiotherapy for Oligometastatic Head and Neck Cancer European Organisation for Research and Treatment of Cancer - EORTC Recruiting 2026-05-28
NCT06256588 A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally… GlaxoSmithKline Recruiting 2026-05-26
NCT07264075 Study Comparing Ivonescimab Alone or Ivonescimab in Combination With Ligufalimab Versus… Groupe Oncologie Radiotherapie Tete et Cou Recruiting 2026-05-20
NCT04966481 Palbociclib and Cetuximab Versus Cetuximab Monotherapy for Patients With CDKN2A-altered… Washington University School of Medicine Recruiting 2026-05-19
See all 1,088 active Head & Neck Cancer trials with filters →

Top sponsors by active trials in this area

M.D. Anderson Cancer Center (35) · National Cancer Institute (NCI) (24) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (23) · Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University (17) · West China Hospital (17) · University Health Network, Toronto (16) · Memorial Sloan Kettering Cancer Center (15) · Sun Yat-sen University (14) · Washington University School of Medicine (12) · Sichuan Baili Pharmaceutical Co., Ltd. (11)

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