ClinicalTrials.gov term: Head and Neck Neoplasms
153 trials changed in the last 30 days: 6 stopped, 74 with notable changes, 73 with minor changes only.
Trial terminated
Also in this update: Results posted: Oct 19, 2026; Enrollment increased: 45 → 65 participants
Thomas Jefferson UniversityPhase 2 NCT03854032 Registry history of NCT03854032 on ClinicalTrials.gov (opens the registry)
Trial status changed: Recruiting → Withdrawn
West China HospitalPhase 1 NCT06741982 Registry history of NCT06741982 on ClinicalTrials.gov (opens the registry)
Recruitment suspended
City of Hope Medical CenterPhase 1 NCT03975231 Registry history of NCT03975231 on ClinicalTrials.gov (opens the registry)
Withdrawn before enrolling
Dana-Farber Cancer InstitutePhase 2 NCT07513324 Registry history of NCT07513324 on ClinicalTrials.gov (opens the registry)
Trial status changed: Recruiting → Withdrawn
Also in this update: Study completion moved earlier from Jan 1, 2027 to Mar 31, 2026; Primary completion moved earlier from Dec 1, 2026 to Mar 31, 2026
Fifth Affiliated Hospital, Sun Yat-Sen UniversityPhase 2 NCT05290194 Registry history of NCT05290194 on ClinicalTrials.gov (opens the registry)
Trial terminated
Also in this update: Primary completion date changed from estimate of May 1, 2028 to Jul 29, 2026; Final enrollment: 11 participants (planned 24)
Mayo ClinicNot specified NCT05575440 Registry history of NCT05575440 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Jun 30, 2026 to Jun 30, 2028
Also in this update: Enrollment increased: 70 → 110 participants; Interventions modified
CSPC Megalith Biopharmaceutical Co.,Ltd.Phase 2 NCT07254585 Registry history of NCT07254585 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Oct 30, 2026 to Jun 25, 2027
Also in this update: Study completion pushed from Oct 31, 2026 to Jun 25, 2027
Novartis PharmaceuticalsPhase 1 NCT03891953 Registry history of NCT03891953 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Nov 30, 2029 to Dec 25, 2032
National Cancer Institute (NCI)Phase 3 NCT06589804 Registry history of NCT06589804 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Jun 30, 2026 to Jun 30, 2027
Hoffmann-La RochePhase 1/2 NCT02650401 Registry history of NCT02650401 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Dec 31, 2026 to Oct 31, 2027
Also in this update: Enrollment increased: 292 → 473 participants; Study completion pushed from Jun 1, 2027 to Mar 30, 2028
Bicara TherapeuticsPhase 1 NCT04429542 Registry history of NCT04429542 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Dec 31, 2026 to Apr 20, 2030
Also in this update: Enrollment increased: 470 → 540 participants; Study completion pushed from Mar 21, 2028 to Jul 22, 2030
SystImmune Inc.Phase 1 NCT05983432 Registry history of NCT05983432 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Dec 1, 2026 to Jan 1, 2029
Also in this update: Study completion pushed from Dec 1, 2031 to Jan 1, 2034
NRG OncologyPhase 2/3 NCT02135042 Registry history of NCT02135042 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Sep 2, 2031 to Sep 2, 2032
Also in this update: Study completion pushed from Apr 21, 2032 to Sep 2, 2033
Jonsson Comprehensive Cancer CenterNot applicable NCT07612293 Registry history of NCT07612293 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Jan 1, 2027 to Jan 31, 2030
National Cancer Institute (NCI)Phase 3 NCT03811015 Registry history of NCT03811015 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Jul 2026 to Jul 2027
Also in this update: Enrollment closed, study ongoing; Trial sites reduced: 8 → 5 locations
Instituto do Cancer do Estado de São PauloPhase 2 NCT06638931 Registry history of NCT06638931 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from May 31, 2026 to May 31, 2028
M.D. Anderson Cancer CenterEarly Phase 1 NCT02790853 Registry history of NCT02790853 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Dec 31, 2026 to Dec 31, 2027
National Cancer Institute (NCI)Phase 2 NCT02465060 Registry history of NCT02465060 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Aug 12, 2026 to Dec 31, 2027
Also in this update: Study completion pushed from Oct 31, 2026 to Sep 1, 2028
Fondazione Policlinico Universitario Agostino Gemelli IRCCSNot specified NCT06385132 Registry history of NCT06385132 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Mar 31, 2026 to Mar 31, 2027
Also in this update: Recruitment opened; Study completion pushed from Sep 30, 2026 to Mar 31, 2027
Fondazione Policlinico Universitario Agostino Gemelli IRCCSNot specified NCT07129525 Registry history of NCT07129525 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Also in this update: Trial sites reduced: 205 → 202 locations
Merus B.V.Phase 3 NCT06525220 Registry history of NCT06525220 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Jul 31, 2026 to Dec 31, 2026
BicycleTx LimitedPhase 1/2 NCT04180371 Registry history of NCT04180371 on ClinicalTrials.gov (opens the registry)
Trial completed
Incyte Biosciences International SàrlPhase 2 NCT05287113 Registry history of NCT05287113 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Study completion date changed from estimate of Dec 2026 to Sep 30, 2026
Instituto Nacional de Cancer, BrazilPhase 1 NCT05308732 Registry history of NCT05308732 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Also in this update: Study completion pushed from Aug 15, 2026 to Aug 6, 2027; Primary completion date changed from estimate of Jun 15, 2026 to Aug 7, 2026
Avacta Life Sciences LtdPhase 1 NCT04969835 Registry history of NCT04969835 on ClinicalTrials.gov (opens the registry)
Trial completed
Maastricht Radiation OncologyNot specified NCT04655469 Registry history of NCT04655469 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Interventions modified; Primary completion date changed from estimate of Nov 1, 2026 to Aug 1, 2026
West China HospitalPhase 2 NCT06508606 Registry history of NCT06508606 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Jun 30, 2026 to Nov 30, 2026
Also in this update: Enrollment increased: 115 → 160 participants; Study completion pushed from Dec 30, 2026 to Dec 30, 2028
Medicenna Therapeutics, Inc.Phase 1/2 NCT05086692 Registry history of NCT05086692 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Oct 31, 2026 to Jan 5, 2027
Novartis PharmaceuticalsNot specified NCT07770074 Registry history of NCT07770074 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Grey Wolf TherapeuticsPhase 1/2 NCT06923761 Registry history of NCT06923761 on ClinicalTrials.gov (opens the registry)
Trial completed
Medical College of WisconsinNot applicable NCT05538533 Registry history of NCT05538533 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Primary completion date changed from estimate of Nov 30, 2026 to May 6, 2025
National Cancer Institute (NCI)Phase 1/2 NCT04708470 Registry history of NCT04708470 on ClinicalTrials.gov (opens the registry)
Enrollment increased: 285 → 330 participants
ModeX Therapeutics, An OPKO Health CompanyPhase 1/2 NCT06239194 Registry history of NCT06239194 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Aug 30, 2027 to Sep 29, 2027
Also in this update: Start date changed from estimate of Aug 30, 2026 to Sep 29, 2026; Study completion pushed from Aug 30, 2029 to Sep 29, 2029
Sun Yat-sen UniversityPhase 3 NCT07796789 Registry history of NCT07796789 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Also in this update: Final enrollment: 88 participants (planned 119)
M.D. Anderson Cancer CenterPhase 2 NCT04870762 Registry history of NCT04870762 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Primary completion date changed from estimate of Jul 2026 to Mar 9, 2026
Groupe Oncologie Radiotherapie Tete et CouPhase 2 NCT03726775 Registry history of NCT03726775 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsPhase 2 NCT05977907 Registry history of NCT05977907 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Primary completion date changed from estimate of Dec 31, 2025 to Oct 2, 2025; Final enrollment: 39 participants (planned 80)
Geisinger ClinicNot specified NCT05862792 Registry history of NCT05862792 on ClinicalTrials.gov (opens the registry)
Trial completed
Maastricht Radiation OncologyNot specified NCT05565313 Registry history of NCT05565313 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Primary completion date changed from estimate of Jun 19, 2026 to May 6, 2026; Final enrollment: 7 participants (planned 25)
Ohio State University Comprehensive Cancer CenterPhase 1 NCT07149220 Registry history of NCT07149220 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Final enrollment: 30 participants (planned 57)
Marmara UniversityNot specified NCT07068711 Registry history of NCT07068711 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Primary completion date changed from estimate of Feb 18, 2026 to Feb 18, 2025
Hopital ForcillesNot specified NCT06387004 Registry history of NCT06387004 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Primary completion date changed from estimate of Nov 30, 2026 to Dec 22, 2025
Instituto do Cancer do Estado de São PauloNot applicable NCT04522570 Registry history of NCT04522570 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Aug 2027 to Dec 2027
University of Michigan Rogel Cancer CenterNot applicable NCT07529080 Registry history of NCT07529080 on ClinicalTrials.gov (opens the registry)
Trial sites reduced: 142 → 138 locations
And 1 more change in the last 30 days
BioNTech SEPhase 2/3 NCT04534205 Registry history of NCT04534205 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 19 → 27 locations
Avenzo Therapeutics, Inc.Phase 1/2 NCT07038343 Registry history of NCT07038343 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Dec 31, 2026 to May 1, 2027
Mayo ClinicPhase 2 NCT06265285 Registry history of NCT06265285 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Jul 2026 to Dec 2026
Groupe Oncologie Radiotherapie Tete et CouPhase 2 NCT03070366 Registry history of NCT03070366 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Dec 18, 2026 to May 15, 2027
Mayo ClinicPhase 2 NCT07285044 Registry history of NCT07285044 on ClinicalTrials.gov (opens the registry)
Enrollment increased: 167 → 190 participants
Also in this update: Primary completion date changed from estimate of Aug 3, 2028 to Jun 16, 2026
AstraZenecaPhase 1 NCT05647122 Registry history of NCT05647122 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 1 → 7 locations
Bicara TherapeuticsPhase 2 NCT07807163 Registry history of NCT07807163 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Mar 2027 to Jun 2027
Also in this update: Enrollment increased: 51 → 60 participants
British Columbia Cancer AgencyNot specified NCT07621146 Registry history of NCT07621146 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 3 → 10 locations
And 1 more change in the last 30 days
Eli Lilly and CompanyPhase 4 NCT07822880 Registry history of NCT07822880 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 203 → 231 locations
Bicara TherapeuticsPhase 2/3 NCT06788990 Registry history of NCT06788990 on ClinicalTrials.gov (opens the registry)
Trial sites reduced: 197 → 194 locations
And 1 more change in the last 30 days
Merus B.V.Phase 3 NCT06496178 Registry history of NCT06496178 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 11 → 16 locations
Perspective TherapeuticsPhase 1/2 NCT06710756 Registry history of NCT06710756 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 91 → 94 locations
Daiichi SankyoPhase 2 NCT06172478 Registry history of NCT06172478 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 8 → 12 locations
ALX Oncology Inc.Phase 1 NCT07085091 Registry history of NCT07085091 on ClinicalTrials.gov (opens the registry)
Trial sites reduced: 23 → 20 locations
AstraZenecaPhase 1 NCT05877599 Registry history of NCT05877599 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 303 → 307 locations
ECOG-ACRIN Cancer Research GroupPhase 3 NCT06475989 Registry history of NCT06475989 on ClinicalTrials.gov (opens the registry)
Primary completion date changed from estimate of Aug 31, 2027 to Jun 30, 2026
GlaxoSmithKlinePhase 1 NCT05277051 Registry history of NCT05277051 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 14 → 18 locations
National Cancer Institute (NCI)Phase 2 NCT07281417 Registry history of NCT07281417 on ClinicalTrials.gov (opens the registry)
Enrollment increased: 118 → 173 participants
University of Southern CaliforniaNot specified NCT07259304 Registry history of NCT07259304 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 8 → 12 locations
SWOG Cancer Research NetworkPhase 2 NCT07062354 Registry history of NCT07062354 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 200 → 212 locations
Alliance for Clinical Trials in OncologyPhase 3 NCT06992427 Registry history of NCT06992427 on ClinicalTrials.gov (opens the registry)
Study completion pushed from Dec 31, 2026 to Nov 30, 2027
Also in this update: Primary completion date changed from estimate of Dec 31, 2026 to Nov 30, 2025
Klus Pharma Inc.Phase 1/2 NCT04152499 Registry history of NCT04152499 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 18 → 23 locations
Alliance for Clinical Trials in OncologyNot applicable NCT07059884 Registry history of NCT07059884 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 1 → 4 locations
Sarasota Memorial Health Care SystemNot specified NCT06868459 Registry history of NCT06868459 on ClinicalTrials.gov (opens the registry)
Study completion pushed from Sep 30, 2026 to Mar 31, 2027
Astellas Pharma Global Development, Inc.Phase 2 NCT04225117 Registry history of NCT04225117 on ClinicalTrials.gov (opens the registry)
Study completion pushed from Oct 2, 2026 to Sep 1, 2027
City of Hope Medical CenterPhase 1 NCT02432963 Registry history of NCT02432963 on ClinicalTrials.gov (opens the registry)
Interventions modified
ExelixisPhase 1 NCT05176483 Registry history of NCT05176483 on ClinicalTrials.gov (opens the registry)
Study completion moved earlier from Jul 14, 2027 to Nov 25, 2026
Boehringer IngelheimPhase 1 NCT05068102 Registry history of NCT05068102 on ClinicalTrials.gov (opens the registry)
Primary completion date changed from estimate of Dec 23, 2026 to Apr 15, 2026
USWM CT, LLCPhase 1 NCT04044859 Registry history of NCT04044859 on ClinicalTrials.gov (opens the registry)
Study completion pushed from Sep 10, 2026 to Jan 10, 2027
Mayo ClinicPhase 1/2 NCT05232851 Registry history of NCT05232851 on ClinicalTrials.gov (opens the registry)
Study completion moved earlier from Feb 2030 to Jul 2027
Also in this update: Primary completion moved earlier from Feb 2028 to Jul 2027
Providence Health & ServicesPhase 2 NCT05913388 Registry history of NCT05913388 on ClinicalTrials.gov (opens the registry)
Interventions modified
Shanghai 6th People's HospitalNot specified NCT06738888 Registry history of NCT06738888 on ClinicalTrials.gov (opens the registry)
Study completion pushed from Aug 11, 2026 to Jul 14, 2027
City of Hope Medical CenterNot applicable NCT02293954 Registry history of NCT02293954 on ClinicalTrials.gov (opens the registry)
Registry marked status Unknown (sponsor has not verified the record since Jun 2024); last known: Active, Not Recruiting
Shanghai Henlius BiotechPhase 2 NCT05513573 Registry history of NCT05513573 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Not Yet Recruiting
DyameoNot specified NCT06618170 Registry history of NCT06618170 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Apr 2024); last known: Recruiting
Hospital of Stomatology, Wuhan UniversityPhase 3 NCT05798793 Registry history of NCT05798793 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2021); last known: Not Yet Recruiting
Guiyang Medical UniversityPhase 2 NCT05039606 Registry history of NCT05039606 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Active, Not Recruiting
Taichung Veterans General HospitalNot specified NCT06617910 Registry history of NCT06617910 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Active, Not Recruiting
Taichung Veterans General HospitalNot specified NCT06612697 Registry history of NCT06612697 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Not Yet Recruiting
Guangzhou University of Traditional Chinese MedicineNot applicable NCT06609070 Registry history of NCT06609070 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Not Yet Recruiting
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityNot specified NCT06599801 Registry history of NCT06599801 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Recruiting
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityNot specified NCT06592755 Registry history of NCT06592755 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Feb 2024); last known: Recruiting
Second Affiliated Hospital of Xi'an Jiaotong UniversityNot specified NCT06286631 Registry history of NCT06286631 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Jul 2024); last known: Recruiting
Tseung Kwan O Hospital, Hong KongNot applicable NCT06225765 Registry history of NCT06225765 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Recruiting
Fondazione Policlinico Universitario Agostino Gemelli IRCCSNot specified NCT05878964 Registry history of NCT05878964 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Nov 2022); last known: Recruiting
Xiangya Hospital of Central South UniversityNot specified NCT05872880 Registry history of NCT05872880 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Active, Not Recruiting
Guy's and St Thomas' NHS Foundation TrustNot specified NCT05785247 Registry history of NCT05785247 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2022); last known: Recruiting
Universidad Rey Juan CarlosNot applicable NCT05562375 Registry history of NCT05562375 on ClinicalTrials.gov (opens the registry)
Changed
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Active, Not Recruiting
Grupo Español de Tratamiento de Tumores de Cabeza y CuelloNot specified NCT04970134 Registry history of NCT04970134 on ClinicalTrials.gov (opens the registry)
Changed
Registry verification sweep
Changed
| First posted | Trial | Sponsor | Phase |
|---|---|---|---|
| 2026-10-15 | NCT07874880 MTX-531-001 Phase 1 Study in Advanced Solid Tumors | MEKanistic Therapeutics, Inc. new | Phase 1 |
| 2026-10-14 | NCT07873450 SumMET: Study of [225Ac]Ac-FL-261 in Participants With Solid Tumors Overexpressing c-MET | Full-Life Technologies UK Limited new | Phase 1/2 |
| 2026-10-08 | NCT07864974 Predictors of Patient-Reported Outcomes for Maxillectomy Patients | Dr. Merve Benli new | |
| 2026-10-01 | NCT07851857 Prophylactic Antibiotic Duration in Head and Neck Cancer Surgery (PROTECT-HN Trial) | AC Camargo Cancer Center new | Phase 3 |
| 2026-10-01 | NCT07851818 Screening Psychosocial Distress in Head and Neck Cancer | Hôpital NOVO new | |
| 2026-09-25 | NCT07840456 Safety and Efficacy of Ruxolitinib in Patients With HNSCC and High NLR Treated With… | University Hospital, Basel, Switzerland new | Phase 2 |
| 2026-09-25 | NCT07842211 Feasibility and Validation of an Automated AI-Enabled Deep Ultraviolet (DUV) Cytology… | Anh Le new | |
| 2026-09-24 | NCT07838857 Evaluation of Adherence to Rehabilitation: Autonomous and Guided, in the Observation and… | Hopital Forcilles new | |
| 2026-09-23 | NCT07836829 Risk Factors of Jaw Osteoradionecrosis in Oral Cavity Cancer Patients Post-Radiotherapy | AO Innovation Translation Center new | |
| 2026-09-21 | NCT07831083 Skin Cancer Among Outdoor Workers | Assuta Medical Center new |
| Early Phase 1 | 33 | |
| Phase 1 | 218 | |
| Phase 1/2 | 153 | |
| Phase 2 | 594 | |
| Phase 2/3 | 33 | |
| Phase 3 | 190 | |
| Phase 4 | 22 |
Sun Yat-sen University (124) · M.D. Anderson Cancer Center (74) · National Cancer Institute (NCI) (46) · Memorial Sloan Kettering Cancer Center (41) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (36) · Fudan University (29) · West China Hospital (29) · Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University (22) · University Health Network, Toronto (22) · Mayo Clinic (19)