University Health Network, Toronto clinical trial pipeline

27 trials changed in the last 30 days: 0 stopped, 16 with notable changes, 11 with minor changes only.

1. Notable

   NAUTICAL · Neoadjuvant Upper Tract Invasive Cancer Trial…NAUTICAL · Neoadjuvant Upper Tract Invasive Cancer Trial (NAUTICAL)

   Primary completion pushed from Dec 2026 to Dec 2027

   Also in this update: Completion pushed from Dec 2027 to Dec 2028

   University Health Network, Toronto·Phase 3· NCT04574960· Registry history of NCT04574960 on ClinicalTrials.gov (opens the registry)

   Updated Oct 6, 2026

2. Notable

   Auto-PLTS · Autologous Cold-stored Apheresis Platelets

   Primary completion pushed from Dec 31, 2026 to Dec 31, 2027

   Also in this update: Recruitment opened; Completion pushed from Apr 30, 2027 to Apr 30, 2028

   University Health Network, Toronto·Phase 2/3· NCT07064954· Registry history of NCT07064954 on ClinicalTrials.gov (opens the registry)

   Updated Oct 5, 2026

3. Notable

   Ket-CBT · I-CBT and IV Ketamine for Suicidality in…Ket-CBT · I-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial

   Primary completion pushed from Mar 2026 to Mar 31, 2027

   Also in this update: Enrollment reduced: 110 → 76 participants; Enrollment closed, study ongoing

   University Health Network, Toronto·Phase 2· NCT06480500· Registry history of NCT06480500 on ClinicalTrials.gov (opens the registry)

   Updated Oct 6, 2026

4. Notable

   PET/MR Pre- and Post Radiotherapy for Cardiopulmonary Dysfunction…PET/MR Pre- and Post Radiotherapy for Cardiopulmonary Dysfunction Evaluation

   Primary and study completion pushed from Jun 1, 2026 to Sep 1, 2027

   University Health Network, Toronto·Not applicable· NCT04901884· Registry history of NCT04901884 on ClinicalTrials.gov (opens the registry)

   Updated Oct 5, 2026

5. Notable

   SPOT-DM · Semaglutide · Post-Transplant Diabetes Mellitus

   Primary completion pushed from Nov 30, 2027 to Jun 30, 2029

   Also in this update: Enrollment reduced: 74 → 37 participants; Completion pushed from Nov 30, 2027 to Dec 30, 2029

   University Health Network, Toronto·Phase 2/3· NCT06913023· Registry history of NCT06913023 on ClinicalTrials.gov (opens the registry)

   Updated Sep 16, 2026

6. Notable

   Living Donor Liver Transplantation for Unresectable Colorectal…Living Donor Liver Transplantation for Unresectable Colorectal Cancer Liver Metastases

   Primary completion pushed from Dec 2025 to Nov 2026

   Also in this update: Enrollment closed, study ongoing

   University Health Network, Toronto·Not applicable· NCT02864485· Registry history of NCT02864485 on ClinicalTrials.gov (opens the registry)

   Updated Oct 2, 2026

7. Notable

   Vivo Lung Perfusion (IVLP) for Colorectal Cancer Metastatic to…Vivo Lung Perfusion (IVLP) for Colorectal Cancer Metastatic to Lung

   Primary completion pushed from Aug 1, 2026 to Aug 1, 2031

   University Health Network, Toronto·Phase 1· NCT05611034· Registry history of NCT05611034 on ClinicalTrials.gov (opens the registry)

   Updated Sep 29, 2026

8. Notable

   A2 to O Lung Transplants

   Primary completion pushed from Dec 31, 2026 to Dec 31, 2027

   University Health Network, Toronto·Not applicable· NCT05581745· Registry history of NCT05581745 on ClinicalTrials.gov (opens the registry)

   Updated Sep 29, 2026

9. Notable

   COMPARISON · Comprehensive Genomic Profiling of Colorectal…COMPARISON · Comprehensive Genomic Profiling of Colorectal Cancer · Isolated Liver Metastases to Understand Response & Resistance to Cancer Therapy

   Primary and study completion pushed from Jun 29, 2026 to Jun 29, 2027

   University Health Network, Toronto·Not specified· NCT03364621· Registry history of NCT03364621 on ClinicalTrials.gov (opens the registry)

   Updated Sep 28, 2026

10. Notable

    NIP IT! · Non-Invasive Artificial Intelligence-Based Platform…NIP IT! · Non-Invasive Artificial Intelligence-Based Platform MonIToring Program (NIP IT!)

    Primary and study completion pushed from Jun 2027 to Jun 2028

    Also in this update: Enrollment increased: 500 → 800 participants

    University Health Network, Toronto·Not specified· NCT05196087· Registry history of NCT05196087 on ClinicalTrials.gov (opens the registry)

    Updated Sep 28, 2026

11. Notable

    MicroUSgFLA · Micro-ultrasound-Guided Focal Laser Ablation for…MicroUSgFLA · Micro-ultrasound-Guided Focal Laser Ablation for Intermediate-Risk Prostate Cancer: Safety & Effectiveness

    Primary completion pushed from May 31, 2026 to May 31, 2028

    Also in this update: Completion pushed from Dec 31, 2027 to Dec 31, 2028

    University Health Network, Toronto·Not applicable· NCT07339943· Registry history of NCT07339943 on ClinicalTrials.gov (opens the registry)

    Updated Sep 25, 2026

12. Notable

    LIBERATE · Liquid Biopsy Evaluation and Repository Development at…LIBERATE · Liquid Biopsy Evaluation and Repository Development at Princess Margaret

    Primary and study completion pushed from Jul 6, 2026 to Jul 6, 2027

    University Health Network, Toronto·Not specified· NCT03702309· Registry history of NCT03702309 on ClinicalTrials.gov (opens the registry)

    Updated Sep 25, 2026

13. Notable

    Virtual Rehabilitation for Cancer Survivors

    Primary completion pushed from Jun 30, 2026 to Sep 30, 2028

    Also in this update: Completion pushed from Nov 30, 2026 to Nov 30, 2028

    University Health Network, Toronto·Not applicable· NCT05898789· Registry history of NCT05898789 on ClinicalTrials.gov (opens the registry)

    Updated Sep 24, 2026

14. Notable

    CeASE · Cervicothoracic Sympathetic Block Evaluation for Post…CeASE · Cervicothoracic Sympathetic Block Evaluation for Post COVID Condition

    Primary endpoint(s) modified

    Also in this update: Interventions modified

    University Health Network, Toronto·Phase 4· NCT07468604· Registry history of NCT07468604 on ClinicalTrials.gov (opens the registry)

    Updated Sep 29, 2026

15. Notable

    ADOPTCanVets · Co-Adaptation of an Digital Pain Management…ADOPTCanVets · Co-Adaptation of an Digital Pain Management Program for Canadian Veterans

    Recruitment opened

    Also in this update: Start date pushed from Sep 1, 2026 to Sep 14, 2026

    University Health Network, Toronto·Not specified· NCT07818980· Registry history of NCT07818980 on ClinicalTrials.gov (opens the registry)

    Updated Sep 18, 2026

16. Notable

    Vagina-View · Imaging Feasibility

    Recruitment opened

    Also in this update: Start date changed from estimate of Sep 30, 2026 to Sep 15, 2026

    University Health Network, Toronto·Not applicable· NCT07818850· Registry history of NCT07818850 on ClinicalTrials.gov (opens the registry)

    Updated Sep 17, 2026

• Stopped: an ongoing trial was terminated, suspended or withdrawn.
• Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
• Minor: routine progress and housekeeping, such as sites added or enrollment closed.