Disease landscape

Breast Cancer clinical trials

Get alerts when Breast Cancer trials change

4,220 active trials 2,279 recruiting 426 Phase 3 1,358 sponsors 549 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 61 of 549 changes on 20 trials

2026-09-05
Trial terminated
Trial terminated: No accrual in one year
Primary endpoint(s) modified
Results posted: 2026-09-04
Final enrollment: 12 participants (planned 34)
Primary completion confirmed: March 2024 (last estimated June 2025)
NCT04315233 Ribociclib&Belinostat In Patients w Metastatic Triple Neg Breast Cancer & Recurrent… · University of Utah · Phase 1
2026-08-22
Trial terminated
Trial terminated: The trial was terminated due to sponsor decision.
Enrollment reduced: 136 → 3 participants
Primary completion moved earlier: 2030-06-01 → 2026-06-24
Completion moved earlier: 2030-06-01 → 2026-06-24
NCT07214662 A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-0587 as a… · Genentech, Inc. · Phase 1
2026-08-28
Withdrawn before enrolling
Trial withdrawn: Other - Protocol moved to Withdrawn
Enrollment reduced: 24 → 0 participants
NCT06982222 Testing the Safety of the Anti-cancer Drug, Sn-117m-DTPA, for Advanced Cancers That Have… · National Cancer Institute (NCI) · Phase 1
2026-08-21
Trial terminated
Trial terminated: Study logistics or limited study population, as defined by the iclusion/exclusion criteria, leading to a poor recruitment
Primary completion moved earlier: 2028-03 → 2026-07-23
Completion moved earlier: 2029-09 → 2026-07-23
NCT06595563 HER2 Molecular Imaging With 89Zr-trastuzumab PET/CT as a Predictive Biomarker for… · Jules Bordet Institute · Phase 2
2026-08-18
Suspended trial terminated
NCT07173101 Clinical Investigation of the Effects of Semiconductor Embedded Therapeutic Garments on… · University of Utah · Phase 2
2026-08-21
Trial terminated
Trial terminated: Difficulties in recruitment
NCT06643455 Mindfulness Intervention for Improving Nutrition in the Digital Kitchen Among Stage I-III… · Fred Hutchinson Cancer Center
2026-08-15
Trial status changed: Recruiting → Withdrawn
Trial withdrawn: No accrual
Enrollment reduced: 100 → 0 participants
Primary completion pushed: 2025-12 → 2025-12-31
Completion moved earlier: 2026-12 → 2025-12-31
NCT06052345 Paclitaxel-induced Polyneuropathy in Breast Cancer: Early Detection, Risk Factors… · Theodoros Foukakis
2026-08-13
Trial status changed: Recruiting → Withdrawn
Trial withdrawn: no patients were able to be enrolled
Enrollment reduced: 30 → 0 participants
Primary completion pushed: 2026-06-30 → 2026-08-10
Completion pushed: 2026-06-30 → 2026-08-10
NCT06610097 TNBC Gut Microbiota During Neoadjuvant Treatment · Scripps Health
2026-08-07
Trial terminated
Trial terminated: Principal Investigator's departure
Enrollment reduced: 60 → 34 participants
Primary completion moved earlier: 2026-06-01 → 2026-04-02
Completion moved earlier: 2026-11-01 → 2026-08-02
NCT07165756 "Mon Parcours de Vie" Localized Breast Cancer: Announcement, Support, Information on the… · Institut de Cancérologie de Lorraine
2026-09-05
Primary completion pushed: 2026-09-30 → 2027-12-31
Completion pushed: 2026-09-30 → 2027-12-31
NCT06274515 A Study to Investigate Mechanisms of Resistance to Breast Cancer Therapies · Hoffmann-La Roche · Phase 4
2026-09-04
Primary completion pushed: 2025-11-28 → 2027-02-10
NCT06271837 A Study of T-DXd as Monotherapy or in Combination With Anti-cancer Agents in Patients… · AstraZeneca · Phase 2
2026-09-02
Primary completion pushed: 2028-06 → 2030-03
Completion pushed: 2028-06 → 2030-03
NCT05645536 Safety Extension Study for Subjects With HR+, HER2- Breast Cancer for Subjects Who Have… · Tolmar Inc. · Phase 3
2026-09-05
Primary completion pushed: 2027-02 → 2029-06
Primary endpoint(s) modified
Enrollment increased: 495 → 575 participants
Interventions modified
Completion pushed: 2027-04 → 2029-06
Trial arms changed: 9 → 11
NCT06400472 A Study of Sofe-M in Participants With Selected Advanced Solid Tumors · Eli Lilly and Company · Phase 1
2026-09-03
Primary completion pushed: 2026-09-01 → 2027-03-24
Completion pushed: 2026-09-01 → 2027-03-24
NCT05548127 TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With… · Pfizer · Phase 1/2
2026-09-04
Primary completion pushed: 2026-04 → 2026-12
Enrollment closed, study ongoing
Completion pushed: 2026-04 → 2026-12
NCT06337084 Diagnostic Efficacy and Dosimetry of MNPR-101-DFO*-89Zr in Patients With Solid Tumors · Monopar Therapeutics · Phase 1
2026-09-03
Primary completion pushed: 2026-03 → 2027-03
Completion pushed: 2026-03 → 2027-03
NCT03893955 A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy… · AbbVie · Phase 1
2026-09-01
Primary completion pushed: 2026-07-01 → 2027-07-01
Completion pushed: 2026-10-01 → 2027-10-01
NCT06460298 ProAgio in Combination With Gemcitabine in Patients With Metastatic Triple Negative… · ProDa BioTech, LLC · Phase 1/2
2026-09-04
Primary completion pushed: 2026-07-27 → 2026-12
NCT03820830 Palbociclib for HR Positive / HER2-negative Isolated Locoregional Recurrence of Breast… · ETOP IBCSG Partners Foundation · Phase 3
2026-09-02
Primary completion pushed: 2027-01-01 → 2028-01-01
Completion pushed: 2027-01-01 → 2028-01-01
NCT03401385 First-in-human Study of DS-1062a for Advanced Solid Tumors (TROPION-PanTumor01) · Daiichi Sankyo Co., Ltd. · Phase 1
2026-09-01
Primary completion pushed: 2025-10-01 → 2026-12-31
Completion pushed: 2025-10-31 → 2026-12-31
NCT06075810 A Study of Oral MBQ-167 in Participants With Advanced Breast Cancer · MBQ Pharma · Phase 1

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-03 NCT07803549 The Effect of Self-Management Interventions Among Patients With Breast Cancer… Al-Zaytoonah University of Jordan new
2026-09-03 NCT07801898 Neoadjuvant Endocrine Therapy Combined With Chemotherapy in ER-positive, HER2-negative… The Second Hospital of Anhui Medical University new Phase 2
2026-09-02 NCT07799909 Behavioral Activation for Cancer-Related Fatigue After Breast Cancer Surgery Huaidong Cheng new
2026-09-02 NCT07798895 Opioid-Free Versus Opioid-Based Anesthesia in Modified Radical Mastectomy Muhammad Fiqhi Amiruddin new
2026-08-25 NCT07784036 JYP0035 Capsules Plus Fulvestrant in PIK3CA-Mutant HR+/HER2- Advanced Breast Cancer Chengdu JOYO pharma Co., Ltd. new Phase 3
2026-08-24 NCT07781852 Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and… Lumina Pharmaceuticals Inc new Early Phase 1
2026-08-24 NCT07782814 An Investigation Into Dielectric Testing for the Evaluation and Characterisation of… Zedsen Limited new
2026-08-24 NCT07780955 Multimodal Assessment of Cryotherapy for Paclitaxel-Induced Neuropathy Azienda Sanitaria dell'Alto Adige new
2026-08-24 NCT07781163 Evaluation of the Safety and Efficacy of Single-Port Robot-Assisted Endoscopic… Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine new
2026-08-24 NCT07782866 MindVybe tVNS/APS for Wellbeing in Breast Cancer Survivors The Healing Consciousness Foundation new

Active trials by phase

Early Phase 1
44
Phase 1
314
Phase 1/2
250
Phase 2
901
Phase 2/3
34
Phase 3
392
Phase 4
66
Not charted: 2,219 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 4,220

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06274515 A Study to Investigate Mechanisms of Resistance to Breast Cancer Therapies Hoffmann-La Roche Recruiting 2026-09-04
NCT07257484 Tirzepatide's Role in Postmenopausal HR+ Breast Cancer Survivors Weill Medical College of Cornell University Recruiting 2026-07-22
NCT07252726 Evaluating Dose Timing (Morning vs Evening) of Endocrine-based Therapies in Metastatic… Ottawa Hospital Research Institute Recruiting 2026-07-17
NCT07600164 Real-world Study of Pyrotinib-containing Regimens of Advanced HER2-positive Breast Cancer Peking University People's Hospital Recruiting 2026-07-13
NCT07220967 A Study of Antibiotic Delivery to Prevent Infection After Breast Tissue Expander Placement Memorial Sloan Kettering Cancer Center Recruiting 2026-07-10
NCT07695259 Olaparib+Trastuzumab+Pertuzumab Neoadjuvant for Elderly HER2+ Breast Cancer Wen-Ming Cao Recruiting 2026-07-10
NCT05753618 Evaluating Omission of Granulocyte Colony-stimulating Factors in Breast Cancer Patients… Ottawa Hospital Research Institute Recruiting 2026-07-08
NCT06169371 Abemaciclib Dose Escalation to Maintain Intensity (ADE-MI) University of Illinois at Chicago Recruiting 2026-07-07
NCT05183126 Pharmacokinetic Study of Skeletal Muscle Area-based Paclitaxel Infusion in Patients With… University of Michigan Rogel Cancer Center Recruiting 2026-07-02
NCT05376878 An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+… City of Hope Medical Center Recruiting 2026-07-01
NCT03096418 Neoadjuvant Weekly Paclitaxel and Biomarkers of Therapy Response University of Wisconsin, Madison Recruiting 2026-06-16
NCT04921137 Evaluating Harms and Benefits of Endocrine Therapy in Patients ≥70 Years of Age With… Ottawa Hospital Research Institute Recruiting 2026-05-28
NCT07578064 A Randomized, Self-controlled Post-marketing Clinical Study on the Comparison of Shengbai… Hongxia Wang Recruiting 2026-05-11
NCT07195344 Study Aiming to Compare the Plasma Exposure of the Payload (Free-DXd) in Patients Treated… Institut Claudius Regaud Recruiting 2026-05-05
NCT07042581 A Study of Revaree Plus in People With Breast Cancer Memorial Sloan Kettering Cancer Center Recruiting 2026-02-06
NCT07308717 Gabapentin And Breast Surgery Decision Architecture Randomization Trial (GABS-DART)… Memorial Sloan Kettering Cancer Center Recruiting 2025-12-30
NCT07257679 Gentle Touch for Post-Mastectomy Lymphedema I.R.C.C.S. Fondazione Santa Lucia Recruiting 2025-12-02
NCT06934239 A Trial Comparing Screening Mammography With and Without Assistance From Artificial… Jonsson Comprehensive Cancer Center Recruiting 2025-11-26
NCT06230055 Intrathecal Chemotherapy Through Ommaya Reservoir Upon Her-2 Negative Breast Cancer With… Fudan University Recruiting 2025-11-25
NCT06072807 Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer Weill Medical College of Cornell University Recruiting 2025-11-24
NCT06429761 Phase 4 Study to Assess the Safety of Trastuzumab Deruxtecan, in Indian Patients AstraZeneca Recruiting 2025-11-24
NCT07158164 DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment Rutgers, The State University of New Jersey Recruiting 2025-11-13
NCT06574022 Post-mastectomy Recovery: Comparing Preoperative PECS-II Blocks With Intraoperative… University of Cincinnati Recruiting 2025-11-04
NCT05206331 CEM to Reduce Biopsy Rates for Less Than Highly Suspicious Breast Abnormalities: a… Margarita Louise Zuley Recruiting 2025-10-08
NCT06491680 Cardiotoxicity in Breast Cancer Patients Helwan University Recruiting 2025-09-22
See all 4,220 active Breast Cancer trials with filters →

Top sponsors by active trials in this area

Fudan University (137) · Memorial Sloan Kettering Cancer Center (105) · M.D. Anderson Cancer Center (89) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (59) · National Cancer Institute (NCI) (55) · AstraZeneca (52) · Dana-Farber Cancer Institute (49) · Mayo Clinic (49) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (43) · City of Hope Medical Center (42)

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