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AstraZeneca clinical trial pipeline

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554 active trials 262 recruiting 192 Phase 3 10 disease areas 149 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 59 of 149 changes on 20 trials

2026-08-08
Trial terminated
Trial terminated: This decision is based on strategic portfolio prioritization
Enrollment reduced: 60 → 8 participants
Trial sites reduced: 45 → 6 locations
Primary completion moved earlier: 2027-01-08 → 2026-06-24
Completion moved earlier: 2027-11-11 → 2026-06-24
NCT07037420 ALXN2420 Versus Placebo in Combination With Somatostatin Analogs in Participants With… · Phase 2
2026-08-27
Primary completion pushed: 2029-02-13 → 2029-06-04
Trial sites expanded: 104 → 132 locations
Completion pushed: 2029-12-20 → 2030-06-06
NCT07611110 AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant… · Phase 3
2026-08-28
Primary completion pushed: 2029-10-30 → 2031-03-06
Recruitment opened
Completion pushed: 2029-10-30 → 2031-03-06
NCT07681596 A Modular, Phase I/II, Multicentre Study to Evaluate AZD4045, in Participants With… · Phase 1/2
2026-08-25
Primary completion pushed: 2026-12-04 → 2027-04-09
Completion pushed: 2026-12-04 → 2027-04-09
NCT06980428 A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of… · Phase 1
2026-08-20
Primary completion pushed: 2026-11-13 → 2028-02-11
Primary endpoint(s) modified
Completion pushed: 2027-06-29 → 2028-09-15
Trial arms changed: 3 → 4
NCT06137118 AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia · Phase 1/2
2026-08-18
Primary completion pushed: 2027-01-28 → 2027-11-03
Completion pushed: 2028-09-06 → 2029-07-16
Trial arms changed: 3 → 5
NCT07069712 A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With… · Phase 2
2026-08-21
Primary completion pushed: 2028-06-30 → 2029-12-31
Completion pushed: 2028-06-30 → 2029-12-31
NCT06494540 NIS to Examine the Effectiveness of TDC in Patients With Metastatic Non-squamous NSCLC…
2026-08-11
Primary completion pushed: 2027-06-07 → 2027-12-06
Completion pushed: 2027-10-05 → 2028-04-05
NCT06183931 Study of ALXN2220 Versus Placebo in Adults With ATTR-CM · Phase 3
2026-08-08
Primary completion pushed: 2026-10-30 → 2027-10-04
Enrollment increased: 790 → 1000 participants
Completion pushed: 2026-10-30 → 2027-10-04
NCT06471257 A Study to Investigate Efficacy and Safety of PT027 Compared With PT007 in Symptomatic… · Phase 3
2026-07-31
Primary completion pushed: 2029-03-30 → 2029-12-18
Primary endpoint(s) modified
Enrollment increased: 500 → 788 participants
Completion pushed: 2030-10-18 → 2031-12-30
Trial arms changed: 3 → 4
NCT06380751 Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6… · Phase 3
2026-07-31
Primary completion pushed: 2026-07-06 → 2026-11-11
NCT04784715 Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and… · Phase 3
2026-08-14
Primary completion pushed: 2027-11-24 → 2028-04-21
NCT06526793 Surovatamig (AZD0486) as Monotherapy in Participants With Relapsed/Refractory (R/R)… · Phase 2
2026-08-13
Primary completion pushed: 2027-11-01 → 2028-02-07
Completion pushed: 2027-11-01 → 2028-02-07
NCT05417594 Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in… · Phase 1/2
2026-08-04
Primary completion pushed: 2027-06-15 → 2027-12-31
Completion pushed: 2028-12-15 → 2029-06-30
NCT07029737 A Study to Evaluate Acalabrutinib, in Combination With the R-CHOP Standard of Care, for… · Phase 2
2026-07-30
Primary completion pushed: 2026-08-11 → 2026-11-17
Completion moved earlier: 2027-09-30 → 2027-06-28
NCT06219941 AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2 · Phase 2
2026-08-05
Primary completion pushed: 2026-12-31 → 2029-03-31
Primary endpoint(s) modified
Completion pushed: 2026-12-31 → 2029-03-31
Trial arms changed: 0 → 2
NCT05999877 PICAROS - Acalabrutinib RWE on 1L CLL in Spain
2026-08-14
Primary endpoint(s) modified
Trial completed
NCT06465485 STEP: Phase IIIb Study of Benralizumab to Step-down Maintenance Therapy in Patients With… · Phase 3
2026-08-04
Primary endpoint(s) modified
Enrollment reduced: 1116 → 9 participants
Phase changed: Phase 3 → Phase 1
Trial sites reduced: 32 → 3 locations
Primary completion moved earlier: 2030-02-21 → 2027-01-29
Completion moved earlier: 2032-07-29 → 2027-01-29
Trial arms changed: 5 → 2
NCT07000149 A Study to Investigate the Efficacy and Safety of Volrustomig ± Casdatifan vs Nivolumab +… · Phase 1
2026-08-14
Primary endpoint(s) modified
Enrollment reduced: 4490 → 4000 participants
Trial arms changed: 2 → 4
NCT06252753 Observational Study Protocol: LIVER-R
2026-08-14
Primary endpoint(s) modified
Trial sites expanded: 1 → 59 locations
NCT07481526 A Prospecitve Multicenter, Observational Registry Study

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-08-27 NCT07790198 Tezepelumab CRSwNP Real World Study (CREW Study) Not Yet Recruiting
2026-08-26 NCT07787117 QUARTZ: Comparative Effectiveness of Switching From Albuterol to Albuterol/Budesonide… Not Yet Recruiting
2026-08-25 NCT07783737 China Glomerulonephritis Kidney Transplant Recipient Cohort: A Prospective Multicenter… Not Yet Recruiting
2026-08-25 NCT07784270 A Study to Evaluate Effect of AZD6234 in Adult Participants With Type 2 Diabetes Mellitus… Phase 3 Not Yet Recruiting
2026-08-25 NCT07784725 A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight… Phase 3 Recruiting
2026-08-24 NCT07783308 A Phase I Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics… Phase 1 Not Yet Recruiting
2026-08-20 NCT07775404 A Study to Investigate the Efficacy and Safety of Elecoglipron in Asian Participants With… Phase 3 Recruiting
2026-08-20 NCT07776509 A Study to Evaluate Effect of AZD6234 as an Adjunct to Incretin-based Therapies in Adult… Phase 3 Not Yet Recruiting
2026-08-19 NCT07774403 A Study of AZD0292 in Chinese Participants With Bronchiectasis and Chronic Pseudomonas… Phase 2 Recruiting
2026-08-14 NCT07764978 Study of AZD0120 in Newly Diagnosed Multiple Myeloma Ineligible for ASCT Phase 3 Recruiting

Active trials by phase

Phase 1
61
Phase 1/2
49
Phase 2
74
Phase 2/3
2
Phase 3
190
Phase 4
14
Not charted: 164 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 554

NCT IDTitleConditionStatusUpdated
Phase 4
NCT07279935 Osimertinib Combined With Chemotherapy in Patients Who Had Distant Recurrence After… Non-small Cell Lung Cancer Recruiting 2026-08-27
NCT07073950 A Study to Investigate the Effect of Budesonide/Glycopyrronium/Formoterol Fumarate… Chronic Obstructive Pulmonary Disease Recruiting 2026-08-24
NCT06531798 Post-marketing Phase 4 Safety & Tolerability Study of Breztri aerosphereTM in Indian… Moderate to Severe COPD Recruiting 2026-08-20
NCT06594068 Prospective Registry Investigating Maternal, Infant, and Lactation Outcomes in… Systemic Lupus Erythematosus Recruiting 2026-08-18
NCT06651970 Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL… Chronic Lymphocytic Leukaemia Recruiting 2026-08-14
NCT07357597 An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd)… Stomatitis Recruiting 2026-08-05
NCT07308574 Post-Marketing Clinical Study of Ravulizumab in Participants With Clinical aHUS aHUS Recruiting 2026-04-20
NCT07221838 A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia… Generalized Myasthenia Gravis Recruiting 2026-04-09
NCT07306949 Real-Life Clinical Efficacy of Acoramidis in Participants With ATTR-CM and Association… Transthyretin-type Cardiac Amyloidosis Recruiting 2026-01-07
NCT06429761 Phase 4 Study to Assess the Safety of Trastuzumab Deruxtecan, in Indian Patients BREAST CANCER Recruiting 2025-11-24
NCT03953300 Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics Asthma Active, Not Recruiting 2026-08-25
NCT06422689 Combination Short-Acting BroNchodilator and Inhaled Corticosteroid Rescue Therapy on… Asthma Active, Not Recruiting 2026-07-16
NCT05457257 Clinical Study to Assess the Efficacy and Safety of Olaparib in Chinese Patients With… Metastatic Castration-resistant Prostate Cancer Active, Not Recruiting 2026-04-21
NCT06610526 A Study of Dapagliflozin in Chinese Adult Patients With Chronic Kidney Disease Chronic Kidney Disease Active, Not Recruiting 2026-01-30
Phase 3
NCT07566195 Long-term Safety and Tolerability of Tozorakimab in Patients With COPD and History of… Chronic Obstructive Pulmonary Disease Recruiting 2026-08-27
NCT07775404 A Study to Investigate the Efficacy and Safety of Elecoglipron in Asian Participants With… Obesity Recruiting 2026-08-27
NCT06283966 A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate… COPD (Chronic Obstructive Pulmonary Disease) Recruiting 2026-08-26
NCT06350097 Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab… Non-small Cell Lung Cancer Recruiting 2026-08-26
NCT06742723 A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy… Chronic Kidney Disease and Hypertension Recruiting 2026-08-26
NCT07611110 AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant… Metastatic Castration-resistant Prostate Cancer Recruiting 2026-08-26
NCT06079671 Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer… Locally Advanced Cervical Cancer Recruiting 2026-08-25
NCT07784725 A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight… Obesity or Overweight Recruiting 2026-08-25
NCT06512883 A Trial to Investigate Benralizumab in Children With Eosinophilic Diseases Eosinophilic Granulomatosis With Polyangiitis (EGPA) Recruiting 2026-08-24
NCT07000357 A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of… Cardiovascular Disease Recruiting 2026-08-24
NCT06952803 A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT… Prostate Cancer Recruiting 2026-08-21
See all 554 active AstraZeneca trials with filters →

Disease areas by active trials

Lung Cancer (82) · Non-Small Cell Lung Cancer (NSCLC) (75) · Breast Cancer (53) · Asthma (31) · Prostate Cancer (26) · Lupus (SLE) (26) · Ovarian Cancer (19) · Leukemia (19) · Liver Cancer (18) · COPD (17)

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