Disease landscape

Lupus (SLE) clinical trials

Get alerts when Lupus (SLE) trials change

545 active trials 316 recruiting 44 Phase 3 307 sponsors 71 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 40 of 71 changes on 20 trials

2026-09-01
Trial terminated
Trial terminated: Study discontinued due to sponsor decision.
Primary completion confirmed: December 2025 (last estimated October 2028)
NCT06342960 KYSA-3: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in… · Kyverna Therapeutics · Phase 1/2
2026-09-01
Trial terminated
Trial terminated: Study discontinued due to sponsor decision.
Primary completion confirmed: May 2026 (last estimated August 2026)
NCT05938725 KYSA-1: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in… · Kyverna Therapeutics · Phase 1/2
2026-08-22
Primary completion pushed: 2027-06-22 → 2027-09-21
Trial sites reduced: 156 → 147 locations
NCT05126277 Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC… · Novartis Pharmaceuticals · Phase 3
2026-08-19
Primary completion pushed: 2026-12 → 2027-12
Completion pushed: 2027-12 → 2028-12
NCT03673748 Treatment of Lupus Nephritis With Allogeneic Mesenchymal Stem Cells · Red de Terapia Celular · Phase 2
2026-08-13
Primary completion pushed: 2026-03-31 → 2026-10
Trial status changed: Not Yet Recruiting → Active, Not Recruiting
Completion pushed: 2026-09-20 → 2026-10-31
NCT07203157 HEAL-SLE: Holistic Energy for Alleviating Lupus Symptoms · NYU Langone Health
2026-08-27
Primary endpoint(s) modified
NCT07783711 Predictors of ICU Admission and In-Hospital Mortality in Hospitalized Patients With Lupus… · Khaled Samir Malak Nashed
2026-08-25
Primary endpoint(s) modified
NCT06711146 Safety and Efficacy of Metabolically Armed CD19 CAR-T Cells (Meta10-19) in the Treatment… · Zhejiang University · Early Phase 1
2026-09-03
Enrollment closed, study ongoing
Trial sites expanded: 101 → 107 locations
NCT06581198 A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus… · Novartis Pharmaceuticals · Phase 2
2026-09-02
Enrollment closed, study ongoing
Trial sites reduced: 114 → 109 locations
Final enrollment: 303 participants (planned 350)
Completion pushed: 2029-05-29 → 2029-07-17
NCT06411249 A Study Describing the Efficacy and Safety of Belimumab Administered in Adult… · GlaxoSmithKline · Phase 4
2026-08-18
Sponsor changed: Bristol-Myers Squibb → Beeline Medicines Corporation
NCT04895696 A Study Evaluating the Efficacy and Safety of Afimetoran Compared With Placebo in… · Beeline Medicines Corporation · Phase 2
2026-09-03
Trial completed
Final enrollment: 24 participants (planned 32)
Primary completion confirmed: December 2025 (last estimated February 2026)
NCT07072611 Clinical Trial to Evaluate Safety, Tolerability, and Pharmacokinetics of SOF-SKN in… · Noxopharm Limited · Early Phase 1
2026-09-01
Recruitment opened
NCT07749651 A Study on the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Single… · Guangdong Hengrui Pharmaceutical Co., Ltd · Phase 1
2026-08-19
Enrollment closed, study ongoing
Primary completion pushed: 2026-06 → 2026-09
Trial sites expanded: 82 → 110 locations
Completion pushed: 2026-09 → 2026-12
NCT06559163 A Study of Obexelimab in Patients With Systemic Lupus Erythematosus · Zenas BioPharma (USA), LLC · Phase 2
2026-08-18
Recruitment opened
Trial sites expanded: 0 → 6 locations
NCT07570862 A Phase 2, Open-Label, Single-Arm Trial of FT819 in Participants With Lupus Nephritis · Fate Therapeutics · Phase 2
2026-08-07
Recruitment opened
NCT07564596 A Phase 1b/2a Study of Budoprutug in Systemic Lupus Erythematosus (SLE) · Climb Bio, Inc. · Phase 1/2
2026-08-12
Trial completed
Completion moved earlier: 2026-10-24 → 2026-01-07
NCT06144710 SG301-SC Injection Safety Study in Subjects With Systemic Lupus Erythematosus · Hangzhou Sumgen Biotech Co., Ltd. · Phase 1
2026-08-11
Recruitment opened
Trial sites expanded: 0 → 4 locations
NCT07483346 IASO-782 in Systemic Lupus Erythematosus · Shanghai IASO Biotechnology Co., Ltd · Phase 1
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT06677801 Immune Cell Subsets in SLE Patients Treated with Telitacicept · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 4
2026-08-08
Recruitment opened
NCT07629583 To Evaluate the Effects of Cevostamab in Participants With Systemic Lupus Erythematosus… · Genentech, Inc. · Phase 1
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT06614270 Anti-CD19 IL-10/IL15 CAR-NK Cells in Refractory/Relapsed Autoimmune Diseases · Second Affiliated Hospital, School of Medicine, Zhejiang University

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-02 NCT07799116 Study to Evaluate the Safety and Preliminary Efficacy of CD19 CAR-T Cell Therapy… Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz new Phase 1/2
2026-08-28 NCT07792733 Team-based Implementation of Hypertension Management in Childhood Lupus Boston Children's Hospital new
2026-08-25 NCT07783711 Predictors of ICU Admission and In-Hospital Mortality in Hospitalized Patients With Lupus… Khaled Samir Malak Nashed new
2026-08-24 NCT07783269 A Basket Study of CTA313 in Participants With Active Autoimmune Diseases Imviva Bio new Phase 1
2026-08-21 NCT07778446 A Study to Test CRT-402 in Refractory Autoimmune Disease Myeloid Therapeutics new Phase 1/2
2026-08-18 NCT07771088 Exploring Biological Mechanisms Underlying the TEACH Intervention for Adolescents With… The Hospital for Sick Children new
2026-08-17 NCT07767188 A Trial to Explore the Efficacy and Safety of O-triple as Initial Therapy in the Active… Zhao Minghui new Phase 3
2026-08-12 NCT07760155 A Phase 2 Study on the Safety and Efficacy of the Anti-BAFF-R Monoclonal Antibody… Shanghai Escugen Biotechnology Co., Ltd new Phase 2
2026-08-12 NCT07760480 Assessing Residual Inflammation and Macrophage Presence in Lupus Nephritis After 3 Months… Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) new Phase 4
2026-07-28 NCT07732309 A Study of ATG-201 in Adult Participants With Autoimmune Diseases Antengene Biologics Limited new Phase 1

Active trials by phase

Early Phase 1
42
Phase 1
114
Phase 1/2
49
Phase 2
64
Phase 2/3
3
Phase 3
41
Phase 4
20
Not charted: 212 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 545

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06594068 Prospective Registry Investigating Maternal, Infant, and Lactation Outcomes in… AstraZeneca Recruiting 2026-08-18
NCT07760480 Assessing Residual Inflammation and Macrophage Presence in Lupus Nephritis After 3 Months… Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Recruiting 2026-08-12
NCT07611214 PRESERVE: LUPKYNIS in Combination With Belimumab, Obinutuzumab or Anifrolumab in Patients… Aurinia Pharmaceuticals Inc. Recruiting 2026-08-03
NCT07719140 Childhood-onset Lupus Nephritis Initial Glucocorticoid-dose Harmonization Trial (LIGHT… Peking Union Medical College Hospital Recruiting 2026-07-22
NCT07087912 Safety and Immunogenicity of the Live Attenuated Tetravalent Butantan-Dengue Vaccine in… University of Sao Paulo General Hospital Recruiting 2026-07-20
NCT07700940 The Efficacy of Empagliflozin on Kidney Functions in Lupus Nephritis Population Ahmed Yehia Ismail Recruiting 2026-07-15
NCT03543839 Trial of Belimumab in Early Lupus Northwell Health Recruiting 2026-06-12
NCT07611747 Carotid Ultrasound-Based Strategy for Primary Prevention of Cardiovascular Events in… Instituto de Investigación Marqués de Valdecilla Recruiting 2026-05-28
NCT07323524 Dapagliflozin in Active Lupus Nephritis Brigham and Women's Hospital Recruiting 2026-05-26
NCT06875960 A Study to Continue the Administration of Deucravacitinib in Participants With Systemic… Bristol-Myers Squibb Recruiting 2026-03-30
NCT07077486 Effects of Telitacicept vs Cyclophosphamide on Lupus Related Interstitial Lung Disease Tongji Hospital Recruiting 2026-01-27
NCT05559671 Safety of the Herpes Zoster Subunit Vaccine in Lupus NYU Langone Health Recruiting 2025-12-26
NCT07225387 Safety and Efficacy of Combination Belimumab and Voclosporin in the Treatment of… NephroNet, Inc. Recruiting 2025-11-06
NCT05207358 Minimizing Glucocorticoid Administration in Patients With Proliferative Lupus Nephritis Institutul Clinic Fundeni Recruiting 2022-03-03
NCT06411249 A Study Describing the Efficacy and Safety of Belimumab Administered in Adult… GlaxoSmithKline Active, Not Recruiting 2026-09-01
NCT07381465 Efficacy and Safety of IL-1 Inhibitors in Mild to Moderate Systemic Lupus Erythematosus Chinese SLE Treatment And Research Group Active, Not Recruiting 2026-07-15
NCT05879419 Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases University of Sao Paulo General Hospital Active, Not Recruiting 2026-05-04
NCT07035834 SGLT-2 Inhibitors on Albuminuria in Chronic Kidney Disease Patients With Lupus Nephritis… Federico II University Not Yet Recruiting 2025-06-25
NCT06763783 Vaccination Against Herpes Zoster in Patients With Inflammatory Rheumatic Diseases Region Skane Enrolling by Invitation 2025-01-10
NCT06677801 Immune Cell Subsets in SLE Patients Treated with Telitacicept Second Affiliated Hospital, School of Medicine, Zhejiang University Active, Not Recruiting 2024-11-07
Phase 3
NCT06617325 A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants… UCB Biopharma SRL Recruiting 2026-09-04
NCT07438496 A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus Janssen Research & Development, LLC Recruiting 2026-08-28
NCT06711887 Phase III Extension Study of Efficacy and Safety of Ianalumab With or Without Study… Novartis Pharmaceuticals Recruiting 2026-08-24
NCT05799378 Effects of Stopping Hydroxychloroquine in Elderly Lupus Disease NYU Langone Health Recruiting 2026-08-20
NCT07430306 A Study to Evaluate the Treatment Outcomes of Subcutaneous Anifrolumab in… AstraZeneca Recruiting 2026-08-20
See all 545 active Lupus (SLE) trials with filters →

Top sponsors by active trials in this area

AstraZeneca (26) · Assiut University (22) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (13) · The Children's Hospital of Zhejiang University School of Medicine (11) · Novartis Pharmaceuticals (10) · Sohag University (8) · Assistance Publique - Hôpitaux de Paris (7) · China Immunotech (Beijing) Biotechnology Co., Ltd. (7) · Tongji Hospital (7) · Beijing GoBroad Hospital (6)

Get alerts when Lupus (SLE) trials change
Status changes, date slips, and new sponsor entrants: detected daily, delivered to your inbox.
Start monitoring free