Sponsor pipeline

Mayo Clinic clinical trial pipeline

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817 active trials 502 recruiting 15 Phase 3 67 disease areas 196 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-10-02

What changed in the last 30 days showing 51 of 196 changes on 20 trials

2026-09-24
Recruitment suspended
Recruitment suspended: Pending receipt of study drug from sponsor
NCT07708961 Temozolomide, With or Without WSD0922-FU, for the Treatment of EGFR-Mutant, IDH-Wildtype… · Phase 2
2026-09-25
Trial terminated
Trial terminated: Slow accrual; lack of eligible study participants
Final enrollment: 11 participants (planned 24)
Primary completion confirmed: July 2026 (last estimated May 2028)
NCT05575440 Evaluation of 18F-TFB PET/CT Scan in Patients With Differentiated Thyroid Cancer
2026-09-19
Trial status changed: Recruiting → Withdrawn
Trial withdrawn: Unable to start study.
NCT04730609 Dexmedetomidine for Intraoperative Shivering in Scheduled Elective Cesarean Delivery · Phase 4
2026-09-04
Withdrawn before enrolling
Trial withdrawn: Sponsor declined to fund study due to inability to agree on IP.
NCT07349771 Axatilimab Plus Standard of Care Therapy for the Prevention of Graft Versus Host Disease… · Phase 2
2026-09-16
Trial terminated
Trial terminated: Funds expired
Final enrollment: 14 participants (planned 20)
Primary completion confirmed: October 2025 (last estimated January 2029)
NCT06274034 MUSE-S Headband System for Improving Anxiety and Insomnia Among Breast Cancer Survivors · Early Phase 1
2026-09-09
Trial terminated
Trial terminated: PI has passed away
Sponsor changed: Sanjeet S. Grewal → Mayo Clinic
Final enrollment: 1 participants (planned 5)
Primary completion confirmed: September 2026 (last estimated March 2026)
NCT06280092 Allogenic Adipose-derived Mesenchymal Stem Cells(AMSCs) for Epilepsy During Deep Brain… · Early Phase 1
2026-09-15
Trial terminated
Trial terminated: Unable to reach enrollment target before the forum date of 9/17/2026
Final enrollment: 1 participants — 2% of the 50 planned
Primary completion confirmed: September 2026 (last estimated January 2028)
NCT07644702 WE-CARE Community Health Forums to Increase Breast Cancer Screening and Clinical Trial…
2026-09-09
Withdrawn before enrolling
Trial withdrawn: Resource reallocation
Primary completion moved earlier: 2026-10 → 2026-08
Completion moved earlier: 2026-10 → 2026-08
NCT07014982 Remote Assessment of Digital Neurologic Testing
2026-10-02
Primary completion pushed: 2027-05-30 → 2029-05-25
Completion pushed: 2027-05-30 → 2029-05-25
NCT06078709 Preoperative Hypofractionated Radiotherapy With FOLFOX for Esophageal or Gastroesophageal… · Phase 2
2026-10-02
Primary completion pushed: 2027-02-15 → 2027-08-01
Completion moved earlier: 2028-02-15 → 2027-08-01
NCT05222620 SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial · Phase 2
2026-10-02
Primary completion pushed: 2027-04-29 → 2030-12-02
Completion pushed: 2027-04-29 → 2033-12-02
NCT06918132 Cemiplimab and Fianlimab Before Surgery for the Treatment of Stage IB-IIIB Non-Small Cell… · Phase 2
2026-10-02
Primary completion pushed: 2028-08-01 → 2029-09-06
Completion pushed: 2029-08-01 → 2029-09-06
NCT05541016 De-Escalated Adjuvant and Definitive Radiation Therapy Informed by DART 2.0 ctHPV-DNA · Phase 2
2026-10-02
Primary completion pushed: 2028-06-30 → 2029-08-05
Completion pushed: 2028-06-30 → 2029-08-05
NCT06997068 Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and… · Phase 2
2026-10-02
Primary completion pushed: 2026-11-30 → 2029-11-30
Completion pushed: 2026-11-30 → 2031-11-30
NCT05898646 Daratumumab Maintenance Therapy for Improving Survival in Patients With Light Chain… · Phase 2
2026-10-02
Primary completion pushed: 2029-04-30 → 2029-09-01
Completion moved earlier: 2034-04-30 → 2032-09-01
NCT07301268 GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or… · Phase 2
2026-10-02
Primary completion pushed: 2027-01-30 → 2027-07-30
Completion pushed: 2027-01-30 → 2027-07-30
NCT05557877 Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer · Phase 2
2026-10-02
Primary completion pushed: 2027-03-15 → 2028-11-11
Completion pushed: 2030-10-16 → 2036-11-11
NCT03516617 Acalabrutinib With or Without Obinutuzumab in Treating Patients With Early-Stage Chronic… · Phase 2
2026-10-01
Primary completion pushed: 2026-12-18 → 2027-05-15
Completion pushed: 2026-12-18 → 2027-05-15
NCT07285044 The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home… · Phase 2
2026-10-02
Primary completion pushed: 2027-09-01 → 2028-09-01
Completion pushed: 2027-09-01 → 2028-09-01
NCT07025226 Medication Combinations of Dasatinib, Quercetin, Fisetin, Temozolomide, LMP744, and… · Early Phase 1
2026-10-02
Primary completion pushed: 2027-12-16 → 2029-12-16
Completion pushed: 2027-12-16 → 2031-12-16
NCT06630104 Understanding the Mechanisms of Clonal and Non-clonal Cytopenia Following CAR-T Therapy…

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-09-30 NCT07850284 SMS-Based Remote Symptom Monitoring for Patients With Plasma Cell Disorders Recruiting
2026-09-28 NCT07843420 Nemolizumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus Phase 2 Not Yet Recruiting
2026-09-24 NCT07838324 A Pilot Investigation of Pain Reprocessing Therapy for Functional Dyspepsia Recruiting
2026-09-24 NCT07840144 Lower Body Negative Pressure to Validate Physiological Monitors Recruiting
2026-09-22 NCT07835295 REMIfentanil (2 vs. 4 mcg/kg) Facilitated Intubation Without Neuromuscular Blockade… Phase 4 Not Yet Recruiting
2026-09-21 NCT07829692 Effectiveness of an 8-week Independent Cadence Retraining Program on Stress Urinary… Recruiting
2026-09-16 NCT07822425 A Study Of Augmented Reality Real-Time Guidance With In-situ Feedback Recruiting
2026-09-16 NCT07823283 Continuous Monitoring of Microvascular Anastomoses: An Observational Trial Recruiting
2026-09-14 NCT07817563 Study Evaluating 68GA-FAPI-46 PET/CT in Patients With Interstitial Lung Disease Phase 1 Not Yet Recruiting
2026-09-14 NCT07817706 Development of a Noninvasive Metric to Measure Small Bowel Sensation - The Small… Recruiting

Active trials by phase

Early Phase 1
19
Phase 1
37
Phase 1/2
17
Phase 2
106
Phase 2/3
3
Phase 3
12
Phase 4
50
Not charted: 573 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 817

NCT IDTitleConditionStatusUpdated
Phase 4
NCT06764095 Enfortumab Vedotin and Pembrolizumab With Cystectomy and/or Ureterectomy for Locally… Locally Advanced Bladder Urothelial Carcinoma Recruiting 2026-10-01
NCT07164131 Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired… Community-acquired Pneumonia Recruiting 2026-09-24
NCT07424625 A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac… Metabolic Acidosis Recruiting 2026-09-21
NCT05856136 A Study to Investigate the Effects of Opioid Exposure on the Ability of the Diaphragm… Respiratory Function Loss Recruiting 2026-09-17
NCT06401642 Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those… Migraine Recruiting 2026-09-17
NCT06972056 Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study Migraine Recruiting 2026-09-16
NCT05285566 Pain Control for Undergoing Costal Cartilage Harvesting Nasal Surgery Recruiting 2026-09-11
NCT07632820 Erector Spinae Plane Block Versus Trigger Point Injection for Chronic Thoracic Myofascial… Back Pain Recruiting 2026-09-09
NCT07283497 Itraconazole Therapy In Bronchiectasis With Airway Mold Bronchiectasis Recruiting 2026-08-21
NCT07594535 The Effect Of Lisinopril On Polycythemia Polycythemia Recruiting 2026-08-21
NCT07218445 The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in… Obesity Recruiting 2026-08-18
NCT06832878 Postoperative Oral Tranexamic Acid in Patients Undergoing Primary Total Joint Arthroplasty Arthroplasty Recruiting 2026-08-10
NCT07285863 A Study Of Effect Of Secretin For In Injection (Chirostim) On Pancreatic Fluid… Exocrine Pancreatic Insufficiency Recruiting 2026-07-07
NCT07174349 Uroselective Alpha-1-Antagonist to Reduce the Incidence and Duration of Postoperative… Urinary Retention Postoperative Recruiting 2026-06-29
NCT07266545 RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression… Unipolar Depression Recruiting 2026-06-22
NCT05837091 Low Sodium Oxybate in Patients With Idiopathic Hypersomnia Idiopathic Hypersomnia Recruiting 2026-05-12
NCT07325240 24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular… Open Angle Glaucoma Recruiting 2026-05-01
NCT07217405 Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis Osteoarthritis Hand Recruiting 2026-04-24
NCT06568549 Reduced Immunosuppression in Older Renal Transplant Recipients With Trugraf®/TRAC… Kidney Transplantation Recruiting 2026-03-20
NCT07213466 Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder Bipolar I Disorder Recruiting 2026-03-11
NCT06782529 Knee Injections for Obese Patients With Knee Arthritis Osteoarthritis of Knee Recruiting 2026-03-10
NCT06525740 Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic… Malignant Female Reproductive System Neoplasm Recruiting 2026-03-04
NCT07223580 A Study Of Corticosteroid On Postoperative Pain After Ureteroscopy For Urinary Calculi Ureteroscopy Recruiting 2026-02-03
NCT06045936 A Study of Contralateral Limb Block Limb Pain, Phantom Recruiting 2026-01-06
NCT03821857 Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease Alzheimer Disease Recruiting 2025-11-24
See all 817 active Mayo Clinic trials with filters →

Disease areas by active trials, top 10 of 67

Breast Cancer (48) · Obesity (27) · Prostate Cancer (27) · Leukemia (18) · Diabetes (17) · Head & Neck Cancer (17) · Heart Disease (17) · Glioma (16) · Heart Failure (16) · Lung Cancer (16)

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