Disease landscape

Obesity clinical trials

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Data updated daily from ClinicalTrials.gov, last refresh 2026-10-20

What changed in the last 30 days

255 trials changed in the last 30 days: 1 stopped, 92 with notable changes, 162 with minor changes only.

  1. Stopped

    Weekly Oral Dose of Ecnoglutide (VRB-101) for Weight Maintenance · Obesity or Overweight With Weight-Related Comorbidities

    Trial terminated

    Also in this update: Final enrollment: 8 participants — 7% of the 120 planned; Primary completion date changed from estimate of Nov 30, 2026 to Sep 11, 2026

    Verdiva Bio Dev LimitedPhase 2 NCT07553299 Registry history of NCT07553299 on ClinicalTrials.gov (opens the registry)

  2. Notable

    STEP-1 · RESET System Pivotal Clinical Trial (Protocol Revision K)

    Primary completion pushed from Mar 30, 2027 to Dec 30, 2027

    Also in this update: Trial sites expanded: 12 → 27 locations; Study completion pushed from May 1, 2027 to Sep 30, 2029; and 4 more changes in the last 30 days

    Morphic Medical Inc.Not applicable NCT04101669 Registry history of NCT04101669 on ClinicalTrials.gov (opens the registry)

  3. Notable

    GEM · Continuous Glucose and E-Monitoring to Support Healthy Weight Gain in Pregnancies - The GEM Study

    Primary completion pushed from Apr 30, 2026 to Jul 30, 2027

    Also in this update: Recruitment opened; Study completion pushed from Jul 30, 2026 to Sep 30, 2027

    Arkansas Children's Hospital Research InstituteNot applicable NCT06666257 Registry history of NCT06666257 on ClinicalTrials.gov (opens the registry)

Show 162 trials with minor changes only
  1. Minor

    SEMA-CKM · Real-world Canadian Retrospective Study Evaluating Longitudinal Semaglutide Use on Cardio-Kidney-Metabolic Outcomes

    Completed without a posted recruiting period

    Also in this update: Primary completion date changed from estimate of Apr 2026 to Sep 28, 2026; Final enrollment: 3392 participants (planned 400)

    LMC Diabetes & Endocrinology Ltd.Not specified NCT07424430 Registry history of NCT07424430 on ClinicalTrials.gov (opens the registry)

  2. Minor

    BaSES · How Does Bariatric Surgery Affect Social Experiences and Well-being - The BaSES-study

    Trial status changed: Enrolling by Invitation → Completed

    Also in this update: Study completion date changed from estimate of Jun 2026 to Nov 5, 2025; Final enrollment: 134 participants (planned 113)

    The Hospital of VestfoldNot applicable NCT05207917 Registry history of NCT05207917 on ClinicalTrials.gov (opens the registry)

  3. Minor

    ENDOCATA · Translational Study Using Human Abdominal Adipose Tissue Biopsies to Investigate the Role of Cannabinoid Receptor 1 (CB1) in Controlling Endocannabinoid and Adipokine Secretion

    Trial completed

    Also in this update: Primary completion date changed from estimate of Sep 2027 to May 19, 2026; Final enrollment: 53 participants (planned 45)

    Centre Hospitalier Universitaire DijonNot applicable NCT04940962 Registry history of NCT04940962 on ClinicalTrials.gov (opens the registry)

  4. Minor
    28 trials marked Unknown by the registry's verification sweep
    1. Minor

      Drug-Drug Interaction (DDI) Study of HDM1002 With Repaglinide, Atorvastatin, Digoxin and Rosuvastatin in Healthy Subjects and Overweight Subjects

      Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Not Yet Recruiting

      Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.Phase 1 NCT06601517 Registry history of NCT06601517 on ClinicalTrials.gov (opens the registry)

      Changed

    Registry verification sweep

    Changed

  5. Minor
    2 trials marked Unknown by the registry's verification sweep

    Registry verification sweep

    Changed

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-10-19 NCT07880847 MORPH-A - Multidisciplinary Obesity Rehabilitation & Psychophysical Health and Awareness Istituti Clinici Scientifici Maugeri SpA new
2026-10-15 NCT07875283 Analgesia After Endoscopic Sleeve Gastroplasty American Hospital of Paris new
2026-10-13 NCT07870668 Intermittent Phentermine for Obesity and Body Composition OSCAR MANUEL TORRES FALCON new Phase 4
2026-10-13 NCT07869758 Gastric On in Obesity Management: Evaluation of the Safety and Efficacy of the 6-Month… Rigicon, Inc. new
2026-10-09 NCT07868978 Radial Artery Dimensions and the Effect of Anaesthetic Induction in Morbid Obesity Hilal Subaşı Artıran new
2026-10-09 NCT07869277 Obesity and Clinical and Cytokine Responses to Periodontal Therapy Emine Çifcibaşı new
2026-10-08 NCT07866365 Longitudinal Tracking Study on the Path Evolution of College Students' Proactive Health… Yingying Tan new
2026-10-05 NCT07857018 Long-term Follow-up After Childhood Obesity Ulla Toft new
2026-10-05 NCT07858331 Patient-centred Intervention With Virtual Support for Obesity and Kidney Transplant Access Kristin Clemens new Phase 4
2026-09-30 NCT07850466 TRPTI Metabolic and GLP-1 Pharmacodynamic Study RDC Clinical Pty Ltd new Phase 4

Active trials by phase

Early Phase 1
26
Phase 1
165
Phase 1/2
36
Phase 2
158
Phase 2/3
12
Phase 3
167
Phase 4
116
Not charted: 2,071 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Top sponsors by active trials in this area

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Active trials