Sponsor pipeline

Amgen clinical trial pipeline

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100 active trials 45 recruiting 49 Phase 3 25 disease areas 30 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 26 of 30 changes on 18 trials

2026-08-12
Trial status changed: Completed → Terminated
Trial terminated: Sponsor Decision
NCT06376045 A Phase 2, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma · Phase 2
2026-09-05
Primary completion pushed: 2026-10-08 → 2027-03-13
Completion pushed: 2028-12-02 → 2029-05-07
NCT06555796 Evaluation of Xaluritamig in High-Risk, Biochemically Recurrent, Non-metastatic… · Phase 1
2026-08-18
Primary completion pushed: 2029-02-09 → 2029-05-10
Completion pushed: 2029-02-09 → 2029-05-10
NCT06745323 A Phase 2, Open-label, Randomized, Multicenter Study of Tarlatamab Dosing Regimens in… · Phase 2
2026-09-05
Enrollment closed, study ongoing
NCT06295679 A Study Assessing Repatha® in Combination With Standard of Care (SOC) Compared With SOC…
2026-08-29
Trial completed
NCT06088199 A Study of Apremilast in Pediatric Participants in Children With Mild to Moderate Plaque… · Phase 3
2026-08-25
Recruitment opened
Trial sites expanded: 0 → 24 locations
NCT07684144 Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of… · Phase 3
2026-08-11
Enrollment closed, study ongoing
Primary completion moved earlier: 2027-02-22 → 2027-01-06
Completion pushed: 2027-08-13 → 2027-12-24
NCT06401044 A Study of AMG 732 in Healthy Participants and Participants With Thyroid Eye Disease · Phase 1/2
2026-08-18
Trial completed
NCT07422285 Comparing the Extent to Which Two Evolocumab Drug Products Are Made Available in the Body… · Phase 1
2026-08-12
Trial completed
NCT06131398 A Study of AMG 355 Alone and in Combination With Pembrolizumab in Participants With… · Phase 1
2026-08-29
Results posted: 2026-08-28
NCT05704738 A Study to Evaluate Rocatinlimab (AMG 451) in Adolescent Participants With… · Phase 3
2026-09-04
Trial sites expanded: 63 → 71 locations
NCT07388498 A Double-blind, Randomized Controlled Trial to Investigate the Efficacy, Safety, and… · Phase 3
2026-09-04
Trial sites expanded: 83 → 87 locations
NCT07684235 Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of… · Phase 3
2026-09-02
Trial sites expanded: 4 → 9 locations
NCT06987539 A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of… · Phase 2
2026-08-28
Trial sites expanded: 24 → 37 locations
NCT07684144 Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of… · Phase 3
2026-08-28
Trial sites expanded: 31 → 83 locations
NCT07684235 Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of… · Phase 3
2026-08-28
Trial sites expanded: 0 → 14 locations
NCT07222553 Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of… · Phase 2
2026-08-18
Trial sites expanded: 36 → 51 locations
NCT07614776 A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA®… · Phase 3
2026-08-15
Trial sites expanded: 0 → 12 locations
NCT07598825 A Trial of Inebilizumab in Participants With Autoimmune Hepatitis · Phase 3
2026-08-15
Trial sites expanded: 54 → 57 locations
NCT07226765 Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea… · Phase 3
2026-08-14
Trial sites expanded: 144 → 149 locations
NCT07213674 A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With… · Phase 3

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-08-21 NCT07778316 Phase 3 Trial of Tarlatamab (SC vs IV) in Extensive-Stage Small Cell Lung Cancer After… Phase 3 Recruiting

Active trials by phase

Phase 1
25
Phase 1/2
4
Phase 2
13
Phase 3
49
Phase 4
6
Not charted: 3 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 100

NCT IDTitleConditionStatusUpdated
Phase 4
NCT06072482 A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis Antineutrophil Cytoplasmic Antibody-associated Vasculitis Recruiting 2026-08-14
NCT06588153 A Study for the Evaluation of Efficacy and Safety of Prolia® in Participants With… Glucocorticoid-induced Osteoporosis Active, Not Recruiting 2026-05-27
NCT06332014 Evaluation of Efficacy and Safety of Prolia in Subjects of Male Osteoporosis in Mainland… Osteoporosis Active, Not Recruiting 2026-02-12
NCT06180278 Long-term, Open-label, Safety Study of Inebilizumab in Neuromyelitis Optica Spectrum… Neuromyelitis Optica Spectrum Disorder Active, Not Recruiting 2025-11-21
NCT05284747 EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction Cardiovascular Disease Active, Not Recruiting 2025-10-06
NCT04586660 Study of XGEVA® (Denosumab) in Chinese Adults and Skeletally Mature Adolescents With… Giant Cell Tumor of Bone Active, Not Recruiting 2025-10-01
Phase 3
NCT04804553 Apremilast Pediatric Study in Children With Active Juvenile Psoriatic Arthritis Active Juvenile Psoriatic Arthritis Recruiting 2026-09-03
NCT06252649 Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without… Metastatic Colorectal Cancer Recruiting 2026-09-03
NCT07037433 Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in… Atherosclerotic Cardiovascular Disease Recruiting 2026-09-03
NCT07388498 A Double-blind, Randomized Controlled Trial to Investigate the Efficacy, Safety, and… Uncontrolled Gout Recruiting 2026-09-03
NCT07684144 Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of… Obesity Recruiting 2026-09-03
NCT07684235 Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of… Obesity Recruiting 2026-09-03
NCT05920356 A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum… Non-Small Cell Lung Cancer (NSCLC) Recruiting 2026-08-27
NCT07213674 A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With… Metastatic Castration-resistant Prostate Cancer Recruiting 2026-08-27
NCT07575399 Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor… Obesity or Overweight Recruiting 2026-08-27
NCT07614776 A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA®… Neovascular Age-related Macular Degeneration Recruiting 2026-08-24
NCT03969329 A Phase 3 Study of Etelcalcetide in Children With Secondary Hyperparathyroidism Receiving… Secondary Hyperparathyroidism Recruiting 2026-08-21
NCT07136012 OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a)… Cardiovascular Disease Recruiting 2026-08-21
NCT07778316 Phase 3 Trial of Tarlatamab (SC vs IV) in Extensive-Stage Small Cell Lung Cancer After… Small Cell Lung Cancer Recruiting 2026-08-21
NCT07226765 Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea… Obstructive Sleep Apnea Recruiting 2026-08-14
NCT07225686 Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea… Obesity Recruiting 2026-08-04
NCT04528082 Apremilast Pediatric Study in Children With Active Oral Ulcers Associated With Behçet's… Behçet Disease Recruiting 2026-07-24
NCT07005128 A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab… Small-cell Lung Cancer Recruiting 2026-07-16
NCT07037459 Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection… Heart Failure With Preserved Ejection Fraction Recruiting 2026-07-02
NCT07366086 Pediatric Safety Follow-up Study of Prior Treatment With Romosozumab for Osteogenesis… Osteogenesis Imperfecta Recruiting 2026-06-22
See all 100 active Amgen trials with filters →

Disease areas by active trials, top 10 of 25

Lung Cancer (18) · Small Cell Lung Cancer (14) · Obesity (12) · Prostate Cancer (7) · Heart Disease (6) · Acute Lymphoblastic Leukemia (ALL) (5) · Diabetes (5) · Leukemia (5) · Non-Small Cell Lung Cancer (NSCLC) (5) · Type 2 Diabetes (3)

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