ClinicalTrials.gov term: Diabetes Mellitus, Type 2

Disease landscape

Type 2 Diabetes clinical trials

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Data updated daily from ClinicalTrials.gov, last refresh 2026-10-20

What changed in the last 30 days

133 trials changed in the last 30 days: 2 stopped, 53 with notable changes, 78 with minor changes only.

  1. Notable

    STEP-1 · RESET System Pivotal Clinical Trial (Protocol Revision K)

    Primary completion pushed from Mar 30, 2027 to Dec 30, 2027

    Also in this update: Trial sites expanded: 12 → 27 locations; Study completion pushed from May 1, 2027 to Sep 30, 2029; and 4 more changes in the last 30 days

    Morphic Medical Inc.Not applicable NCT04101669 Registry history of NCT04101669 on ClinicalTrials.gov (opens the registry)

  2. Notable

    SMART 2D · Montelukast's Effects on Renal and Cardiovascular Health in Adolescents and Young · Type 2 Diabetes

    Primary completion pushed from Feb 2030 to Dec 2030

    Also in this update: Start date pushed from Aug 7, 2026 to Oct 12, 2026; Study completion pushed from Feb 2030 to Dec 2031

    University of Colorado, DenverEarly Phase 1 NCT07409714 Registry history of NCT07409714 on ClinicalTrials.gov (opens the registry)

  3. Notable

    Use of Diabetes Treatment Support System (BAP0527 and Blood Glucose Meter) in Addition to Daily Practice and Treatment With Daily Practice and Treatment Alone · Type 2 Diabetes Mellitus

    Primary endpoint(s) modified

    Also in this update: Sponsor changed: [Redacted] to Astellas Pharma Inc; Results posted: Sep 30, 2026

    Astellas Pharma IncNot specified NCT06156696 Registry history of NCT06156696 on ClinicalTrials.gov (opens the registry)

Show 78 trials with minor changes only
  1. Minor

    Preventing Medication Mismanagement · Dementia Through Automated Medication Dispensing With Facial Recognition and Video Observation

    Trial completed

    Also in this update: Primary completion date changed from estimate of May 31, 2026 to Sep 30, 2025; Final enrollment: 50 participants (planned 70)

    HiDO TechnologiesPhase 2 NCT06691256 Registry history of NCT06691256 on ClinicalTrials.gov (opens the registry)

  2. Minor

    SEMA-CKM · Real-world Canadian Retrospective Study Evaluating Longitudinal Semaglutide Use on Cardio-Kidney-Metabolic Outcomes

    Completed without a posted recruiting period

    Also in this update: Primary completion date changed from estimate of Apr 2026 to Sep 28, 2026; Final enrollment: 3392 participants (planned 400)

    LMC Diabetes & Endocrinology Ltd.Not specified NCT07424430 Registry history of NCT07424430 on ClinicalTrials.gov (opens the registry)

  3. Minor

    ENDOCATA · Translational Study Using Human Abdominal Adipose Tissue Biopsies to Investigate the Role of Cannabinoid Receptor 1 (CB1) in Controlling Endocannabinoid and Adipokine Secretion

    Trial completed

    Also in this update: Primary completion date changed from estimate of Sep 2027 to May 19, 2026; Final enrollment: 53 participants (planned 45)

    Centre Hospitalier Universitaire DijonNot applicable NCT04940962 Registry history of NCT04940962 on ClinicalTrials.gov (opens the registry)

  4. Minor
    18 trials marked Unknown by the registry's verification sweep

    Registry verification sweep

    Changed

  5. Minor
    2 trials marked Unknown by the registry's verification sweep

    Registry verification sweep

    Changed

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-10-16 NCT07877948 Comparative Study of Combination Treatment of Bionerv E+ Versus Vitamin B Complex in… BREGO Life Sciences new
2026-10-15 NCT07875010 Wearable NH₃ Sensor for Remote Non-invasive Monitoring and Diagnosis of Diabetic Kidney… Shanghai Pudong Hospital new
2026-10-15 NCT07876401 Effects of Progressive Muscle Relaxation on Anxiety, Depression, and Quality of Life in… Gul Dural new
2026-10-15 NCT07876258 A Study in Type 2 Diabetes Patients Who Are Taking Moderate Dose Insulin, Looking at the… Aimi Fadilah Mohamad new Phase 3
2026-10-13 NCT07871370 Silymarin Effects on Fatty Liver in Type 2 Diabetics University of Mosul new
2026-10-08 NCT07864805 Electromagnetic Therapy, Peripheral Vascular Diseases, Diabetes Ashraf Abdelaal new
2026-10-06 NCT07861308 Diabetes Distress, Medication Adherence Barriers, Self-Management, and Glycemic Control… Bilecik Seyh Edebali Universitesi new
2026-10-01 NCT07852988 Pancreatin Added to Standard Antihyperglycemic Therapy in Patients With Type 2 Diabetes Silesian Centre for Heart Diseases new Phase 4
2026-09-29 NCT07847177 Nurse-Led Self-Management and Breathing Intervention in Type 2 Diabetes Aziza Ibrahim Mohamed new
2026-09-29 NCT07847593 Probiotics in Obese Patients Treated With Semaglutide Nordic Biotic Sp. z o.o. new

Active trials by phase

Early Phase 1
19
Phase 1
61
Phase 1/2
14
Phase 2
81
Phase 2/3
6
Phase 3
103
Phase 4
113
Not charted: 1,139 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Top sponsors by active trials in this area

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