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Eli Lilly and Company clinical trial pipeline

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228 active trials 115 recruiting 92 Phase 3 50 disease areas 59 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 30 of 59 changes on 20 trials

2026-09-05
Primary completion pushed: 2027-02 → 2029-06
Primary endpoint(s) modified
Enrollment increased: 495 → 575 participants
Interventions modified
Completion pushed: 2027-04 → 2029-06
Trial arms changed: 9 → 11
NCT06400472 A Study of Sofe-M in Participants With Selected Advanced Solid Tumors · Phase 1
2026-08-15
Primary endpoint(s) modified
NCT05869903 A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With… · Phase 3
2026-08-21
Primary endpoint(s) modified
Enrollment increased: 535 → 677 participants
Trial arms changed: 5 → 8
NCT05614739 FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With… · Phase 1
2026-08-22
Recruitment opened
Trial sites expanded: 37 → 40 locations
NCT07613307 A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes Who Observe… · Phase 3
2026-08-21
Trial completed
NCT06921759 A Study to Investigate the Efficacy and Safety of Lebrikizumab in Participants With… · Phase 3
2026-08-26
Trial completed
NCT07592572 A Study of the Effects of Itraconazole on LY4395089 in Healthy Participants · Phase 1
2026-08-25
Trial completed
NCT07232732 A Study of LY3549492 in Healthy Participants and Participants With Overweight or Obesity · Phase 1
2026-08-22
Enrollment closed, study ongoing
Primary completion moved earlier: 2027-10 → 2027-07
Completion moved earlier: 2027-10 → 2027-07
NCT07438444 A Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2… · Phase 4
2026-08-22
Trial completed
NCT06046729 A Study of Eltrekibart (LY3041658) in Adult Participants With Moderate to Severe… · Phase 2
2026-08-21
Recruitment opened
NCT07612267 A Study to Measure Mirikizumab Levels in Breast Milk of Lactating Participants Receiving… · Phase 4
2026-08-20
Recruitment opened
NCT07641504 A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic… · Phase 2
2026-08-20
Recruitment opened
NCT07641517 A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With… · Phase 2
2026-08-22
Recruitment opened
NCT07547540 A Study of LY3971297 in Participants With Heart Failure · Phase 1
2026-08-22
Trial completed
NCT07313813 A Study to Evaluate the Effect of Fasting Duration and Dulaglutide (LY2189265)… · Phase 1
2026-08-22
Trial completed
NCT05241834 A Study of LOXO-260 in Cancer Patients With a Change in a Particular Gene (RET) That Has… · Phase 1
2026-08-22
Enrollment closed, study ongoing
NCT07545590 A Study of Eltrekibart (LY3041658) in Healthy Participants · Phase 1
2026-08-21
Recruitment opened
NCT07738614 A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight · Phase 1
2026-08-21
Recruitment opened
NCT07707375 A Study of LY4268989 (MORF 057) in Healthy Participants · Phase 1
2026-08-21
Recruitment opened
NCT07701083 A Study of Eloralintide (LY3841136) in Healthy Participants · Phase 1
2026-08-21
Recruitment opened
NCT07698210 A Study of LY4178256 in Healthy Participants · Phase 1

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-09-04 NCT07803744 A Study of Tirzepatide (LY3298176) in Participants With Type 1 Diabetes Mellitus and… Phase 1 Not Yet Recruiting
2026-09-03 NCT07801300 A Study of LY5625575 in Healthy Participants and in Participants With Inflammation… Phase 1 Not Yet Recruiting
2026-08-31 NCT07794579 A Study of Orforglipron in Participants With Overweight at Risk of Development of… Phase 3 Not Yet Recruiting
2026-08-31 NCT07794592 A Study Comparing Two Ways of Taking Olomorasib (LY3537982) in Healthy Participants Phase 1 Not Yet Recruiting
2026-08-27 NCT07790861 A Study of Orforglipron (LY3502970) in Chinese Participants With Obesity or Overweight… Phase 3 Not Yet Recruiting
2026-08-26 NCT07787169 A Master Protocol Studying Multiple Amyloid-Targeting Therapies in Healthy Participants… Phase 1 Not Yet Recruiting
2026-08-26 NCT07787182 A Study of LY4405094 in Healthy Participants and Participants With Alzheimer's Disease Phase 1 Not Yet Recruiting
2026-08-25 NCT07783802 A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk… Phase 2 Not Yet Recruiting
2026-08-20 NCT07775300 A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder Phase 3 Not Yet Recruiting
2026-08-17 NCT07767487 A Study of LY4226695 in Healthy Participants Phase 1 Not Yet Recruiting

Active trials by phase

Phase 1
70
Phase 1/2
5
Phase 2
45
Phase 2/3
1
Phase 3
91
Phase 4
10
Not charted: 6 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 228

NCT IDTitleConditionStatusUpdated
Phase 4
NCT06857942 A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation… Psoriasis Recruiting 2026-09-04
NCT07218341 A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic… Chronic Lymphocytic Leukemia Recruiting 2026-09-04
NCT07612267 A Study to Measure Mirikizumab Levels in Breast Milk of Lactating Participants Receiving… Lactation Recruiting 2026-08-20
NCT07247084 A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants… Obesity Recruiting 2026-07-07
NCT06864026 A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in… Psoriatic Arthritis Recruiting 2026-06-11
NCT06876649 A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib Chronic Lymphocytic Leukemia Recruiting 2026-03-02
NCT06876662 A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic… Chronic Lymphocytic Leukemia Recruiting 2026-03-02
NCT07438444 A Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2… Diabetes Mellitus, Type 2 Active, Not Recruiting 2026-08-21
NCT07006792 A Study to See How Well Lebrikizumab Works in Adults and Adolescents With Moderate Atopic… Atopic Dermatitis Active, Not Recruiting 2026-05-22
NCT05433584 A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants… Type 2 Diabetes Active, Not Recruiting 2025-12-12
Phase 3
NCT06439277 A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities… Obesity Recruiting 2026-09-04
NCT06937086 Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With… Ulcerative Colitis Recruiting 2026-09-04
NCT06937099 Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to… Crohn's Disease Recruiting 2026-09-04
NCT07157774 Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated… Elevated Lp(a) Recruiting 2026-09-04
NCT07219966 A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder Alcohol Use Disorder Recruiting 2026-09-04
NCT07222137 A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk… Diabetes Mellitus, Type 1 Recruiting 2026-09-04
NCT07222332 A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults… Diabetes Mellitus, Type 1 Recruiting 2026-09-04
NCT03773965 A Study of Baricitinib in Participants From 1 Year to Less Than 18 Years Old With… Juvenile Idiopathic Arthritis Recruiting 2026-08-24
NCT04844606 A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants… Ulcerative Colitis Recruiting 2026-08-24
NCT05509777 A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease Crohn's Disease Recruiting 2026-08-24
NCT06119581 A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without… Carcinoma, Non-Small-Cell Lung Recruiting 2026-08-24
NCT06338995 A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal… Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Recruiting 2026-08-24
NCT06672549 A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040) Obesity Recruiting 2026-08-24
NCT06672939 A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or… Obesity Recruiting 2026-08-24
NCT06890598 Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With… Carcinoma, Non-Small-Cell Lung Recruiting 2026-08-24
See all 228 active Eli Lilly and Company trials with filters →

Disease areas by active trials, top 10 of 50

Obesity (50) · Diabetes (24) · Breast Cancer (22) · Alzheimer's Disease (16) · Non-Small Cell Lung Cancer (NSCLC) (16) · Lung Cancer (11) · Type 2 Diabetes (8) · Colorectal Cancer (7) · Crohn's Disease (7) · Chronic Kidney Disease (6)

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