Disease landscape

Alzheimer's Disease clinical trials

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897 active trials 520 recruiting 71 Phase 3 487 sponsors 138 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 45 of 138 changes on 20 trials

2026-09-01
Primary completion pushed: 2026-09 → 2027-07
Completion pushed: 2026-10 → 2027-08
NCT06514001 A Study of AMDX-2011P in Participants With Alzheimer's Disease · Amydis Inc. · Phase 2
2026-09-02
Primary completion pushed: 2026-03-31 → 2027-09-30
Enrolling by invitation only
Completion pushed: 2026-04-30 → 2027-12-30
NCT06761066 Efficacy and Safety of NVP-NK4146 in Patients With Mild Cognitive Impairment (MCI) Due to… · NVP Healthcare
2026-08-27
Primary completion pushed: 2028-03 → 2029-02
Completion pushed: 2029-03 → 2030-02
NCT07205601 Study of Intracerebroventricular Injections of Autologous Adipose-Derived Stem Cells… · Regeneration Biomedical, Inc. · Phase 2
2026-08-27
Primary completion pushed: 2028-01 → 2028-09
Completion pushed: 2028-01 → 2028-09
NCT07373067 Repeat Intracerebroventricular Injections of RB-ADSC in Subjects Previously Treated in… · Regeneration Biomedical, Inc. · Phase 1
2026-08-25
Primary completion pushed: 2028-06-30 → 2028-12-30
Completion pushed: 2028-12-31 → 2029-06-30
NCT06432166 2-Hydroxybenzylamine (2-HOBA) Study in Early Alzheimer's Patients · MTI Biotech Inc · Phase 1/2
2026-08-13
Primary completion pushed: 2026-12-31 → 2027-04-30
Enrolling by invitation only
Completion pushed: 2027-04-07 → 2027-08-15
NCT07752784 Evaluate the Concordance Between PET Imaging of [18F]-APN-1607 Injection and Postmortem… · JYAMS PET Research & Development Limited · Phase 3
2026-09-05
Primary completion pushed: 2026-10 → 2029-10
Completion pushed: 2026-10 → 2029-12
NCT06597942 Large-coil Parietal Repetitive Transcranial Magnetic Stimulation (rTMS) for Alzheimer… · University of California, Los Angeles · Phase 1/2
2026-09-05
Primary completion pushed: 2026-09-30 → 2027-06-30
Completion pushed: 2026-12-31 → 2027-09-30
NCT04123314 Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's… · Johns Hopkins University · Early Phase 1
2026-09-03
Primary completion pushed: 2029-03 → 2029-09
Completion pushed: 2029-03 → 2029-09
NCT07413744 The Gut - PRO Study · University of Wisconsin, Madison · Phase 1
2026-09-05
Primary completion pushed: 2026-03-22 → 2026-09-22
Trial status changed: Enrolling by Invitation → Active, Not Recruiting
Completion pushed: 2026-03-22 → 2026-09-22
NCT06940687 Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their… · Yale University
2026-09-05
Primary completion pushed: 2029-05 → 2030-04-01
Completion pushed: 2029-08 → 2030-04-30
NCT07260253 Remotely-supervised Neuromodulation in PPA · Maya Henry
2026-09-04
Primary completion pushed: 2026-08-31 → 2029-07-31
Completion pushed: 2026-08-31 → 2029-07-31
NCT06703541 ADRC Clinical Cohort (Alzheimer's Disease) · Duke University
2026-08-11
Primary completion pushed: 2026-06 → 2027-06
Completion pushed: 2026-12 → 2027-12
NCT05926011 Efficacy of RGn600 in Patients With Mild-to-moderate Alzheimer's Disease · REGEnLIFE SAS
2026-08-08
Primary completion pushed: 2026-06 → 2026-12
Trial sites expanded: 3 → 7 locations
Completion pushed: 2026-07 → 2027-01
NCT07239310 Neuclare Device for Temporary Improvement of Executive Function in Patients With Mild… · Deepsonbio
2026-09-03
Primary completion pushed: 2025-10 → 2026-10
Completion pushed: 2026-01 → 2027-01
NCT06292741 Autonomic Involvement in Patient With Cognitive Decline · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
2026-09-03
Primary completion pushed: 2028-05 → 2028-09
Completion pushed: 2028-07 → 2028-12
NCT07200739 Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients… · Zealand University Hospital
2026-08-25
Primary completion pushed: 2026-01-31 → 2028-01-31
Enrollment closed, study ongoing
Completion pushed: 2026-01-31 → 2028-01-31
NCT03848312 Preventing Alzheimer's With Cognitive Training · University of South Florida · Phase 3
2026-08-21
Primary completion pushed: 2025-12 → 2028-12-31
Completion pushed: 2026-12 → 2029-12-31
NCT04150198 MECHANISMS OF NEURONAL RESILIENCE IN ALZHEIMER'S DISEASE AND ITS FOCAL VARIANTS: A PET/MR… · Institut National de la Santé Et de la Recherche Médicale, France
2026-08-18
Primary completion pushed: 2026-06 → 2027-12
Completion pushed: 2026-06 → 2027-12
NCT04804241 Senicapoc in Alzheimer's Disease · University of California, Davis · Phase 2
2026-08-25
Primary completion pushed: 2026-07-01 → 2027-07-01
Completion pushed: 2026-07-08 → 2027-07-08
NCT04517552 Investigation of Inflammation Using [C-11]-CS1P1 · Tammie L. S. Benzinger, MD, PhD

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-01 NCT07796308 Terazosin And Metabolic Engagement in Alzheimer's Disease Qiang Zhang new Phase 2
2026-08-31 NCT07794670 Randomized Study to Evaluate the Effect of Obicetrapib in Participants With Preclinical… NewAmsterdam Pharma new Phase 2
2026-08-27 NCT07789873 A 28-Day Study of GAL-101 in Participants With Mild to Moderate Alzheimer's Disease Galimedix Therapeutics Inc new Phase 2
2026-08-17 NCT07768579 The Effect of Sequential Therapy on Alzheimer's Disease Dongzhimen Hospital, Beijing new
2026-08-14 NCT07764679 A Clinical Study Evaluating the Diagnostic Performance and Safety of PET for the… HTA Co., Ltd. new Phase 3
2026-08-13 NCT07763392 Establishing Normal Cognitive Test Scores for Adults Using a Voice-Enabled Digital… The Neurology Center of Southern California new
2026-08-11 NCT07758660 Alzheimer's Disease Research Center (ADRC) PET Component Study Patrick Lao new Phase 2
2026-08-11 NCT07757178 Lived Experience Narratives in Dementia University of Nottingham new
2026-08-03 NCT07741526 Safety, Tolerability and Biomarker-based Efficacy of NPI-001 (AT-001) in Subjects With… Arctic Therapeutics new Phase 2
2026-08-03 NCT07741071 N-AD: Orally Administered Nicotinamide Riboside Over Two Years as a Potential Disease… Haukeland University Hospital new Phase 2

Active trials by phase

Early Phase 1
15
Phase 1
63
Phase 1/2
27
Phase 2
103
Phase 2/3
14
Phase 3
57
Phase 4
16
Not charted: 602 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 897

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07633470 A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver… Alpha Cognition, Inc Recruiting 2026-08-28
NCT07688460 Evaluation System for Lecanemab Efficacy Using Gold Electrode ECL to Monitor Alzheimer's… The Fourth Affiliated Hospital of Zhejiang University School of Medicine Recruiting 2026-07-07
NCT05924425 Daridorexant to Treat Insomnia in Patients With Mild Cognitive Impairment and Mild to… University Hospital, Montpellier Recruiting 2026-06-25
NCT07604896 Evaluating the Efficacy and Safety of Lecanemab in Alzheimer's Disease Through… First Affiliated Hospital of Wenzhou Medical University Recruiting 2026-05-22
NCT05004987 Aβ Dynamics in LLMD NYU Langone Health Recruiting 2026-05-06
NCT03821857 Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease Mayo Clinic Recruiting 2025-11-24
NCT05908695 An Efficacy and Safety Study of Sodium Oligomannate (GV-971) for the Treatment of… Green Valley (Shanghai) Pharmaceuticals Co., Ltd. Recruiting 2023-11-09
NCT03082755 Nighttime Agitation and Restless Legs Syndrome in People With Alzheimer's Disease University of Texas at Austin Recruiting 2022-05-18
NCT07579689 Effects of Ginkgo Biloba on Blood Biomarkers in Mild Cognitive Impairment Hanyang University Not Yet Recruiting 2026-06-26
NCT00950430 Imaging of Brain Amyloid Plaques in the Aging Population Mayo Clinic Enrolling by Invitation 2026-06-23
NCT06911944 Amyloid Lowering for Alzheimer's in Down's With Donanemab Investigation Michael Rafii, MD, PhD Not Yet Recruiting 2026-05-15
NCT07034222 12-Month Real-World Safety & Efficacy of Lecanemab in Early Alzheimer's Disease Ruijin Hospital Active, Not Recruiting 2025-06-24
NCT05586750 Statins in Reducing Events in the Elderly Mind (STAREE-Mind) Imaging Substudy Monash University Active, Not Recruiting 2025-05-22
NCT05058040 A Clinical Study to Evaluate the Long-Term Safety Sodium Oligomannate Capsules (GV-971) Green Valley (Shanghai) Pharmaceuticals Co., Ltd. Active, Not Recruiting 2025-01-24
NCT05181475 Long-term Efficacy and Safety Study of GV-971 Green Valley (Shanghai) Pharmaceuticals Co., Ltd. Active, Not Recruiting 2024-11-15
NCT03454646 Comparison of Therapeutic Strategies With Cholinesterase Inhibitors (SOS TRIAL) University Hospital, Bordeaux Not Yet Recruiting 2023-10-06
Phase 3
NCT06126224 A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated… Karuna Therapeutics, Inc., a Bristol Myers Squibb company Recruiting 2026-09-04
NCT06585787 A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's… Karuna Therapeutics, Inc., a Bristol Myers Squibb company Recruiting 2026-08-26
NCT07011745 A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment… Bristol-Myers Squibb Recruiting 2026-08-26
NCT07571161 Donanemab (LY3002813) Trial in Chinese Participants With Cognitively Unimpaired… Eli Lilly and Company Recruiting 2026-08-24
NCT07177352 Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's… Hoffmann-La Roche Recruiting 2026-08-21
NCT06976216 A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment… Bristol-Myers Squibb Recruiting 2026-08-20
NCT06937229 A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in… Bristol-Myers Squibb Recruiting 2026-08-19
NCT05511363 A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated… Karuna Therapeutics, Inc., a Bristol Myers Squibb company Recruiting 2026-08-17
NCT07752784 Evaluate the Concordance Between PET Imaging of [18F]-APN-1607 Injection and Postmortem… JYAMS PET Research & Development Limited Recruiting 2026-08-17
See all 897 active Alzheimer's Disease trials with filters →

Top sponsors by active trials in this area

Eli Lilly and Company (16) · Xuanwu Hospital, Beijing (16) · Washington University School of Medicine (15) · Indiana University (10) · Mayo Clinic (10) · Assistance Publique - Hôpitaux de Paris (8) · Bristol-Myers Squibb (8) · Hoffmann-La Roche (8) · IRCCS San Raffaele (8) · Johns Hopkins University (8)

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