Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE)"

The RAATE proposal is designed to determine the effects of physical activity on risk factors for Alzheimer's Disease in older African American adults. The study will compare a physical activity program to an active control group. There are three main objectives of the protocol: 1) to determine if a physical activity intervention tailored to older African American adults is effective in modifying cognitive function associated with Alzheimer's Disease, 2) to determine if a physical activity intervention tailored to older African American adults is effective in modifying brain function and structure associated with Alzheimer's Disease, and 3) to determine if a physical activity promotion intervention tailored to African American adults is effective at enhancing physiological parameters. The primary endpoints for the study are episodic memory and executive functioning. The secondary outcomes include anthropometry, blood pressure, brain activation, cerebral blood flow, volume of whole brain and white matter hyperintensities, cardiorespiratory fitness, objectively measured physical activity, circulating hormones, and telomere length.

NCT Number	NCT03890861
Lead Sponsor	Pennington Biomedical Research Center Collaborators: National Institute on Aging (NIA)
Conditions	Dementia, Alzheimer Type
Enrollment	125 participants
Start Date	2019-08-09
Primary Completion	2025-11 (estimated)
Study Completion	2026-11 (estimated)
Updated on ClinicalTrials.gov	2024-11-25