ClinicalTrials.gov term: Heart Diseases

Disease landscape

Heart Disease clinical trials

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Data updated daily from ClinicalTrials.gov, last refresh 2026-10-20

What changed in the last 30 days

457 trials changed in the last 30 days: 11 stopped, 202 with notable changes, 244 with minor changes only.

  1. Stopped

    ICAME · Medico-economic Evaluation of Therapeutic Adaptation Guided by the Soluble Suppression of Tumorigenicity 2 (sST-2) Biomarker · Acute Heart Failure

    Trial terminated

    Also in this update: Study completion date changed from estimate of Jan 2027 to Apr 14, 2026; Final enrollment: 154 participants (planned 710)

    University Hospital, MontpellierNot applicable NCT04554277 Registry history of NCT04554277 on ClinicalTrials.gov (opens the registry)

Show 244 trials with minor changes only
  1. Minor

    MIECC-CABG · MIECC vs Conventional Cardiopulmonary Bypass and Systemic Inflammation in CABG

    Enrollment closed, study ongoing

    Also in this update: Study completion moved earlier from Jan 31, 2027 to Oct 30, 2026; Primary completion date changed from estimate of Dec 31, 2026 to Oct 6, 2026

    Bursa Yuksek Ihtisas Training and Research HospitalNot specified NCT07823400 Registry history of NCT07823400 on ClinicalTrials.gov (opens the registry)

  2. Minor

    NorEx · Norwegian Trial of Physical Exercise After Myocardial Infarction

    Trial status changed: Enrolling by Invitation → Active, Not Recruiting

    Also in this update: Study completion moved earlier from Dec 31, 2036 to Dec 31, 2028; Primary completion date changed from estimate of Jul 31, 2028 to May 19, 2025

    Norwegian University of Science and TechnologyNot applicable NCT04617639 Registry history of NCT04617639 on ClinicalTrials.gov (opens the registry)

  3. Minor

    ADMINISTER II · Impact of Nudging Cardiologists to Prescribe Class I Recommendations Foundational- and Additional Medical Therapy in Heart Failure Patients

    Trial status changed: Enrolling by Invitation → Active, Not Recruiting

    Also in this update: Study completion moved earlier from Aug 31, 2028 to Jul 9, 2028; Primary completion moved earlier from Mar 30, 2028 to Jan 9, 2028

    Medisch Spectrum TwenteNot applicable NCT06844006 Registry history of NCT06844006 on ClinicalTrials.gov (opens the registry)

  4. Minor

    Erector Spinae Plane Block and Modified Pectoral Fascial Plane Block for Postoperative Analgesia in Pediatric Cardiac Surgery

    Trial status changed: Enrolling by Invitation → Completed

    Also in this update: Primary completion date changed from estimate of Aug 15, 2026 to Oct 5, 2026; Final enrollment: 50 participants (planned 40)

    Saglik Bilimleri Universitesi Gazi Yasargil Training and Research HospitalNot applicable NCT07740915 Registry history of NCT07740915 on ClinicalTrials.gov (opens the registry)

  5. Minor

    ILOCO-CHD · Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated · Congenital Heart Disease Undergoing Surgical Repair

    Primary completion pushed from Aug 31, 2028 to Dec 31, 2028

    Also in this update: Study completion pushed from Dec 31, 2028 to Jun 30, 2029

    Charite University, Berlin, GermanyPhase 1/2 NCT07486167 Registry history of NCT07486167 on ClinicalTrials.gov (opens the registry)

  6. Minor

    NODULE-SHOCK · Intravascular Lithotripsy With or Without Rotational Atherectomy for Coronary Calcified Nodule Treatment

    Enrollment closed, study ongoing

    Also in this update: Study completion moved earlier from Dec 31, 2027 to Aug 11, 2027; Primary completion date changed from estimate of Dec 31, 2026 to Aug 11, 2026

    Annapoorna KiniNot applicable NCT07000045 Registry history of NCT07000045 on ClinicalTrials.gov (opens the registry)

  7. Minor

    PreVail-PH2 · Pulmonary Artery DenerVation Clinical Study Using the Gradient Denervation System in Heart Failure · Pulmonary Hypertension Group 2 (PreVail-PH2 Study)

    Primary completion pushed from Dec 2026 to Jun 2027

    Also in this update: Study completion pushed from Jul 1, 2028 to Jun 1, 2030

    Gradient Denervation TechnologiesNot applicable NCT06052072 Registry history of NCT06052072 on ClinicalTrials.gov (opens the registry)

  8. Minor

    Diagnostic Sensitivity and Specificity of Pleural Fluid N-Terminal Pro B-type Natriuretic Peptide (NT-proBNP) and Other Biochemical Gradient Criteria in Distinguishing Heart Failure and Non-heart Failure Related Pleural Effusions (CENTRE Study)

    Trial completed

    Also in this update: Primary completion date changed from estimate of Nov 30, 2025 to Jun 30, 2025; Final enrollment: 160 participants (planned 120)

    Chinese University of Hong KongNot specified NCT05797649 Registry history of NCT05797649 on ClinicalTrials.gov (opens the registry)

  9. Minor

    Half SALINE-AF · Very High-Power Short-Duration Radiofrequency Ablation With Half-Normal Saline Irrigation for Pulmonary Vein Isolation

    Primary completion pushed from Sep 14, 2026 to Dec 14, 2026

    Also in this update: Study completion pushed from Sep 14, 2026 to Feb 25, 2027

    First Affiliated Hospital of Ningbo UniversityNot applicable NCT07835126 Registry history of NCT07835126 on ClinicalTrials.gov (opens the registry)

  10. Minor

    The PULSE-LHD · Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy · Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

    Trial sites expanded: 13 → 16 locations

    And 1 more change in the last 30 days

    Pulnovo Medical, Inc.Not applicable NCT07214376 Registry history of NCT07214376 on ClinicalTrials.gov (opens the registry)

  11. Minor
    73 trials marked Unknown by the registry's verification sweep
    1. Minor

      PAMP FA · Predicting Disease Progression in Atrial Fibrillation: A Multiparametric Approach for Prognostic Marker Identification and Personalized Patient Management

      Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Not Yet Recruiting

      IRCCS Policlinico S. DonatoNot specified NCT06647914 Registry history of NCT06647914 on ClinicalTrials.gov (opens the registry)

      Changed

    2. Minor

      Impact of Cardiac Rehabilitation Exercise Therapy on the Quality of Life · Chronic Heart Failure

      Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Not Yet Recruiting

      Daping Hospital and the Research Institute of Surgery of the Third Military Medical UniversityNot applicable NCT06633107 Registry history of NCT06633107 on ClinicalTrials.gov (opens the registry)

      Changed

    3. Minor

      LUNG PDA · Thoracic Ultrasound As a Response to the Closure of Hemodynamically Significant Patent Ductus Arteriosus in Premature Infants

      Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Recruiting

      Fondazione Policlinico Universitario Agostino Gemelli IRCCSNot specified NCT06627374 Registry history of NCT06627374 on ClinicalTrials.gov (opens the registry)

      Changed

    4. Minor

      HURRICANE · Health Improvements by Understanding the Determinants of Residual Risk in Coronary Artery Disease and New Targets for Prevention and Treatment

      Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Recruiting

      Fondazione Toscana Gabriele MonasterioNot specified NCT06601153 Registry history of NCT06601153 on ClinicalTrials.gov (opens the registry)

      Changed

    5. Minor

      CHOICE-FR · Complete Functional Assessment of Intermediate Coronary Artery Stenosis Before and After Transcatheter Aortic Valve Implantation (TAVI) · Severe Symptomatic Aortic Valve Stenosis

      Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Recruiting

      Helios Health Institute GmbHNot applicable NCT05133843 Registry history of NCT05133843 on ClinicalTrials.gov (opens the registry)

      Changed

    Registry verification sweep

    Changed

  12. Minor
    2 trials marked Unknown by the registry's verification sweep

    Registry verification sweep

    Changed

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-10-16 NCT07877116 Sevoflurane Versus Propofol Anesthesia in Intracardiac Echocardiography-Guided Atrial… Hüseyin Ulaş Pinar new Phase 4
2026-10-16 NCT07878520 Effectiveness of the "Aktivplan" Digital Intervention for Supporting Regular… Salzburg Research Forschungsgesellschaft mbH new
2026-10-16 NCT07879144 Digital Nudges to Improve Heart Health Actions After Community Screening in Malaysia… Cardiovascular Advancement and Research Excellence Institute new
2026-10-15 NCT07875088 Real-World Outcomes of Drug-Coated Balloon Angioplasty in Coronary Artery Disease Kristian Rivera new
2026-10-15 NCT07874763 Bachmann's Bundle Versus Right Atrial Appendage Pacing Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) new
2026-10-08 NCT07865936 Cardiovascular Risk Assessment and Coronary Calcium Score in Thai MASLD Patients Watcharasak Chotiyaputta new
2026-10-08 NCT07865884 Tissue Validation of Mammographic Breast Arterial Calcification in Mastectomy Specimens Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital new
2026-10-07 NCT07863674 Cardiovascular Risk Factors in Mexican Women Medicaweb, S.A.C.V. new
2026-10-05 NCT07858578 Transcranial Doppler and Artificial Intelligence Prediction of Postoperative Delirium in… Osman Sila Aydin new
2026-10-02 NCT07856264 PCSK9 Inhibitors in Hyperlipidemia and Atherosclerosis Fundación Santa Fe de Bogota new

Active trials by phase

Early Phase 1
36
Phase 1
75
Phase 1/2
56
Phase 2
229
Phase 2/3
48
Phase 3
288
Phase 4
389
Not charted: 5,946 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Top sponsors by active trials in this area

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Active trials
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