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Cardiac Arrest Bundle of cARE Trial

Study acronym: CABARET
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated December 2, 2024 (before its estimated April 30, 2025 completion). Its status may not reflect the trial's current state.

Record History

  1. Trial status: Not Yet Recruiting to Recruiting Primary completion date: Sep 2024 to Apr 30, 2025 · Completion date: Oct 2024 to Aug 30, 2025 · Start date changed from estimate of Apr 2024 to May 24, 2024 · 1 morev7 Show 4 more changesShow less
    • Primary completion date: Sep 2024 to Apr 30, 2025
    • Completion date: Oct 2024 to Aug 30, 2025
    • Start date changed from estimate of Apr 2024 to May 24, 2024
    • Site details revised
  2. Re-verified, no change to tracked fieldsv6
  3. Start date: Mar 2024 to Apr 2024 Collaborators: 4 to 3v5 Show 1 more changeShow less
    • Collaborators: 4 to 3

    See this version in full on ClinicalTrials.gov ↗

  4. Start date: Nov 2023 to Mar 2024 Enrollment target: 30 to 32 · Primary completion date: May 2024 to Sep 2024 · Completion date: Jul 2024 to Oct 2024 · 1 morev4 Show 4 more changesShow less
    • Enrollment target: 30 to 32
    • Primary completion date: May 2024 to Sep 2024
    • Completion date: Jul 2024 to Oct 2024
    • Secondary endpoints: 11 to 10

    See this version in full on ClinicalTrials.gov ↗

  5. Re-verified, no change to tracked fieldsv3
  6. Secondary endpoints: details revised at 2 of 11 entries Study description shortened, about 10 wordsv2 Show 1 more changeShow less
    • Study description shortened, about 10 words

    See this version in full on ClinicalTrials.gov ↗

  7. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
An out-of-hospital cardiac arrest is a sudden event where the heart stops beating and a person becomes unresponsive. During this event, vital organs in the body receive no blood flow, causing them to shut down. Without intervention to restart the heart, a person effectively dies. In the UK, around 60,000 people experience cardiac arrests each year, with most occurring at home. Despite prompt emergency service response, survival rates are typically low. There is technology available that has the potential to improve survival rates for out-of-hospital cardiac arrests. The intervention involves three devices used together: head-up position CPR (Elegard), active compression-decompression mechanical CPR (Lucas-3), and the Impedance Threshold device (Resqpod-16). When combined, these devices can enhance blood flow during resuscitation, potentially leading to improved initial resuscitation rates and higher rates of survival with normal brain function after a cardiac arrest. A pilot study is planned to test the feasibility of using these devices. The results will inform the design of a larger study to determine if this technology can indeed improve survival rates in out-of-hospital cardiac arrests.
Trial Details
NCT Number NCT05917717
Lead Sponsor University Hospital Southampton NHS Foundation Trust
Collaborators: University of Southampton, South Central Ambulance service, Hampshire and Isle of Wight air Ambulance
Conditions Cardiopulmonary Resuscitation, Cardiac Arrest, Out of Hospital Cardiac Arrest
Enrollment 32 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov