Disease landscape

Heart Failure clinical trials

Get alerts when Heart Failure trials change

1,453 active trials 836 recruiting 77 Phase 3 774 sponsors 176 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 54 of 176 changes on 20 trials

2026-09-01
Withdrawn before enrolling
Trial withdrawn: Due to changes in HFpEF treatment landscape, no recruitment activities were initiated and no participants were enrolled.
Primary completion confirmed: August 2026 (last estimated December 2028)
NCT06536309 Neprilysin Inhibition to Reduce Myocardial Fibrosis in Heart Failure With Preserved… · Brigham and Women's Hospital · Phase 4
2026-09-03
Primary completion pushed: 2026-06 → 2027-06
NCT05763407 Early Feasibility Study of the NORM™ System in Heart Failure Patients (FUTURE-HFII) · Foundry Innovation & Research 1, Limited (FIRE1)
2026-08-18
Primary completion pushed: 2027-09 → 2029-01
Phase changed: Phase 1 → Phase 1/2
Recruitment opened
Enrollment increased: 40 → 126 participants
Completion pushed: 2028-09 → 2030-01
NCT07123779 HS235 Study in Obese Participants With Pulmonary Hypertension and Heart Failure With… · 35Pharma Inc · Phase 1/2
2026-09-03
Primary completion pushed: 2027-07 → 2028-07
Recruitment opened
Trial sites expanded: 1 → 5 locations
NCT07666698 A Study of Metformin to Improve Cardiac Function After LVAD Implantation · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Phase 1/2
2026-09-04
Primary completion pushed: 2026-07-08 → 2026-12-08
Completion pushed: 2026-07-08 → 2026-12-08
NCT06137261 Screening Adults With Obesity to Reduce Heart Failure Events · Franciscus Gasthuis
2026-08-22
Primary completion pushed: 2026-05 → 2026-11
Enrollment closed, study ongoing
Completion pushed: 2026-11 → 2027-12
NCT06682910 Assessment of Safety and Accuracy of the Microtech System in Patients Undergoing Left… · Microtech Medical Technologies, Ltd
2026-09-03
Primary completion pushed: 2026-10-15 → 2027-12
Enrollment closed, study ongoing
Completion pushed: 2027-10-15 → 2028-12
NCT05933083 MCNAIR Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac Rehabilitation · University of California, San Francisco
2026-09-01
Primary completion pushed: 2026-04-06 → 2028-10-31
Completion pushed: 2027-10-06 → 2028-12-31
NCT03480633 Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure · Massachusetts General Hospital
2026-08-26
Primary completion pushed: 2026-07 → 2028-07-16
Completion pushed: 2027-05 → 2028-07-16
NCT06601465 COgnitioN With VERiciGuat Evaluation in Heart Failure · University of Alberta · Phase 2
2026-08-12
Primary completion pushed: 2026-04-30 → 2027-04-30
Trial sites expanded: 9 → 12 locations
Completion pushed: 2026-06-30 → 2027-06-30
NCT07038356 Effects of Continued Administration of Empagliflozin in Patients With Heart Failure on… · Christian Schulze · Phase 3
2026-08-08
Primary completion pushed: 2028-12-01 → 2029-04
Primary endpoint(s) modified
Trial sites expanded: 0 → 10 locations
Completion pushed: 2029-03-01 → 2029-04
NCT07569640 HFrEF Polypill in Sri Lanka RCT · Washington University School of Medicine · Phase 3
2026-08-27
Primary completion pushed: 2026-02-28 → 2027-02-28
Completion pushed: 2026-02-28 → 2027-02-28
NCT03876223 Women's Ischemia Syndrome Evaluation (WISE) Pre-HFpEF · Cedars-Sinai Medical Center
2026-08-27
Primary completion pushed: 2026-05-01 → 2026-11-01
Completion pushed: 2026-07-01 → 2027-01-01
NCT07435662 Optimizing Heart Failure Therapies Among Patients With Limited Access in Denver · Denver Health and Hospital Authority
2026-08-22
Primary completion pushed: 2026-07 → 2027-02
Enrollment reduced: 20 → 18 participants
Trial status changed: Enrolling by Invitation → Recruiting
Completion pushed: 2026-07 → 2027-11
NCT05585125 A Preliminary Study for INFORMED · Weill Medical College of Cornell University · Phase 4
2026-08-15
Primary completion pushed: 2027-09-30 → 2027-12-30
Completion pushed: 2027-09-30 → 2027-12-30
NCT06166654 Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload · Johannes Grand · Phase 4
2026-09-05
Primary endpoint(s) modified
Trial completed
NCT05888233 Allopurinol Improves Heart Function in African Americans With Resistant Hypertension · VA Office of Research and Development · Phase 2
2026-08-07
Primary completion pushed: 2026-06 → 2027-12
Completion pushed: 2026-06 → 2027-12
NCT05700617 Cardiac Power Output in Cardiogenic Shock Patients · University of Chicago · Early Phase 1
2026-08-22
Primary completion pushed: 2025-05 → 2026-03-06
Enrollment reduced: 176 → 63 participants
Trial completed
Completion pushed: 2025-08 → 2026-04-07
NCT06528561 Impact of a Physical Exercise Program on the Self-care Capacity of People Hospitalized… · Centro Hospitalar Universitário de Santo António
2026-08-21
Primary completion pushed: 2026-11 → 2027-08
Completion pushed: 2026-11 → 2027-08
NCT06195059 Contrast Echocardiography During Exercise to Assess Pulmonary Blood Volume · Mayo Clinic
2026-08-20
Primary completion pushed: 2024-12-31 → 2027-03-30
Trial status changed: Enrolling by Invitation → Active, Not Recruiting
Completion pushed: 2026-12-01 → 2028-12-01
NCT05253469 Infective Endocarditis Surgery Using Conventional Prosthetic Valves Versus Cryopreserved… · Centre Cardiologique du Nord

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-04 NCT07804654 Protocolised Natriuresis-Guided Decongestion at Different Diuretic Intensities in Acute… Universiti Teknologi Mara new
2026-09-04 NCT07805213 KV-PREDICT Diagnostic Device in Patients With Heart Failure KardioVis S.r.l. new
2026-09-03 NCT07803471 Yiqi Fumai Lyophilized Injection for Chronic Heart Failure Caused by Coronary Heart… China Academy of Chinese Medical Sciences new
2026-09-03 NCT07801144 Bioimpedance-Guided Diuretics and Cardiac Progression in Asymptomatic Heart Failure Kayseri Training and Research Hospital new
2026-09-01 NCT07798856 Effects of a Multidisciplinary Integrated Care Model on Care Outcomes in Patients With… Chimei Medical Center new
2026-08-31 NCT07795892 Circulating RNA Markers of Ventricular Arrhythmias in Remotely Monitored Patients With… University of Rzeszow new
2026-08-31 NCT07793968 Point of Care NT-proBNP Testing for Suspected New Heart Failure Acute Care University of Stirling new
2026-08-31 NCT07795359 A Study Evaluating an Implantable Cardiac Microcurrent Device in Patients With Chronic… Berlin Heals GmbH new
2026-08-31 NCT07794930 Integrating Values Based Communication in Heart Failure Management Abigail Latimer new
2026-08-31 NCT07795632 Sound Heart Spiritual Combined With Dhikr for Patients With Heart Failure Risqi Wahyu Susanti new

Active trials by phase

Early Phase 1
11
Phase 1
27
Phase 1/2
25
Phase 2
65
Phase 2/3
12
Phase 3
65
Phase 4
80
Not charted: 1,168 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 1,453

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07572032 Delayed Initiation of ARNI and SGLT2i in Heart Failure With Corrected Aetiology… Kyungsub Song Recruiting 2026-09-02
NCT07631156 STEPwise De-escalation and Optimizing Withdrawal of ARNI and SGLT2i in Normalized Heart… Kyungsub Song Recruiting 2026-09-02
NCT07490067 Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol… University of Michigan Recruiting 2026-09-01
NCT07554638 Incretin Therapies in Obesity-related HFpEF Columbia University Recruiting 2026-08-24
NCT05585125 A Preliminary Study for INFORMED Weill Medical College of Cornell University Recruiting 2026-08-21
NCT05276219 DECONGEST-AHF: Vasodilatation or Loop Diuretics in Acute Heart Failure Rigshospitalet, Denmark Recruiting 2026-08-17
NCT06166654 Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload Johannes Grand Recruiting 2026-08-14
NCT07178145 Epicardial Adipose Tissue Composition and Heart Failure With Preserved Ejection Fraction University of Virginia Recruiting 2026-08-11
NCT07397650 Efficacy and Safety With Early Treatment of Finerenone in Hospitalized Patients With… Juntendo University Recruiting 2026-08-10
NCT07482943 The Effect of Dapagliflozin on Exercise and Cardiac Functional Status of Patients After… The University of Hong Kong Recruiting 2026-07-28
NCT06183437 The STOP-MED CTRCD Trial Dinesh Thavendiranathan Recruiting 2026-07-07
NCT07577596 Infusion of Furosemide to Improve Diuretic Efficiency in Acute Heart Failure University of Aarhus Recruiting 2026-07-06
NCT06704633 Sacubitril-valsartan in Patients With Heart Failure With Reduced Ejection Fraction From… Martin Rohacek Recruiting 2026-07-02
NCT05672836 ENAVOgliflozin Outcome Trial in Patients With Severe Aortic Stenosis After Transcatheter… Duk-Woo Park, MD Recruiting 2026-06-29
NCT05793996 The Prevalence of Iron Deficiency and the Effectiveness of Ferinject® in Patients With… Tomsk National Research Medical Center of the Russian Academy of Sciences Recruiting 2026-06-24
NCT06979726 Gator SCALES-WHF: SubCutaneous Administration of Lasix to Eliminate Symptoms of Worsening… University of Florida Recruiting 2026-06-08
NCT07321509 Digoxin After Acute Heart Failure (DIG-DICA) Hospital General de Agudos "Dr. Cosme Argerich" Recruiting 2026-06-02
NCT07617376 Pre-discharge Influenza Vaccination in Patients Hospitalized for Acute Cardiac Conditions Wroclaw Medical University Recruiting 2026-06-01
NCT07527156 Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure Institute for Clinical and Experimental Medicine Recruiting 2026-04-14
NCT07263035 Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure Lakeland Regional Health Systems, Inc. Recruiting 2026-04-09
NCT07513883 The Assessment of Partial Guideline-Directed Medical Therapy Down Titration in Heart… Ziekenhuis Oost-Limburg Recruiting 2026-04-07
NCT07147114 Clinical Trial to Evaluate the Efficacy and Safety in Concomitant Administration of… Gachon University Gil Medical Center Recruiting 2026-04-03
NCT06055452 Effects of SGLT2 Inhibitors in Pre-heart Failure Populations With Hypertension China National Center for Cardiovascular Diseases Recruiting 2026-03-05
NCT07405944 Vericiguat and Reverse Remodeling Indices in Heart Failure University Medical Centre Ljubljana Recruiting 2026-02-12
NCT06793670 Landiolol in Mitral Valve Surgery Università Vita-Salute San Raffaele Recruiting 2025-12-29
See all 1,453 active Heart Failure trials with filters →

Top sponsors by active trials in this area

Mayo Clinic (16) · Yale University (13) · University of Texas Southwestern Medical Center (11) · Brigham and Women's Hospital (10) · National Taiwan University Hospital (10) · The Cleveland Clinic (10) · Assistance Publique - Hôpitaux de Paris (9) · Duke University (9) · Massachusetts General Hospital (9) · University Medical Center Groningen (9)

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