The Cleveland Clinic clinical trial pipeline

28 trials changed in the last 30 days: 2 stopped, 17 with notable changes, 9 with minor changes only.

1. Stopped

   PMEG · Physician Modified Endovascular Grafts · Juxtarenal Aortic…PMEG · Physician Modified Endovascular Grafts · Juxtarenal Aortic Aneurysms

   Trial status changed: Recruiting → Withdrawn

   Sponsor's reason: Physician-Sponsor Retirment

   Also in this update: Primary completion date changed from estimate of Dec 31, 2030 to Sep 15, 2026

   The Cleveland Clinic·Not applicable· NCT06657794· Registry history of NCT06657794 on ClinicalTrials.gov (opens the registry)

   Updated Oct 9, 2026

2. Stopped

   UPLIFT · Cardiac Disease Quality of Life Study

   Trial terminated

   Sponsor's reason: Enrollment goal not met

   Also in this update: Final enrollment: 380 participants (planned 1200); Primary completion date changed from estimate of Dec 2026 to Sep 2, 2022

   The Cleveland Clinic·Not specified· NCT04080492· Registry history of NCT04080492 on ClinicalTrials.gov (opens the registry)

   Updated Sep 17, 2026

3. Notable

   ECHOLASER · Laser Ablation a Salvage Treatment for Obstructive…ECHOLASER · Laser Ablation a Salvage Treatment for Obstructive Benign Prostatic Hyperplasia

   Primary completion pushed from Sep 1, 2026 to Jun 1, 2027

   The Cleveland Clinic·Not specified· NCT07016620· Registry history of NCT07016620 on ClinicalTrials.gov (opens the registry)

   Updated Oct 13, 2026

4. Notable

   AI-HTN · Decision Support Tool · Uncontrolled Hypertension

   Primary completion pushed from Jul 1, 2027 to Jan 2028

   Also in this update: Study completion pushed from Dec 1, 2027 to Jun 2028

   The Cleveland Clinic·Not applicable· NCT07218198· Registry history of NCT07218198 on ClinicalTrials.gov (opens the registry)

   Updated Oct 7, 2026

5. Notable

   Youth Suicide Prevention: CAMS-BI vs. Safety Planning in a…Youth Suicide Prevention: CAMS-BI vs. Safety Planning in a Randomized Trial

   Primary completion pushed from Jan 1, 2027 to Dec 30, 2027

   Also in this update: Study completion pushed from Mar 1, 2027 to Jan 1, 2028

   The Cleveland Clinic·Not applicable· NCT07628192· Registry history of NCT07628192 on ClinicalTrials.gov (opens the registry)

   Updated Oct 7, 2026

6. Notable

   HA35 Acute Alcohol Study

   Primary completion pushed from Oct 1, 2026 to Oct 1, 2028

   Also in this update: Study completion pushed from Oct 1, 2027 to Oct 1, 2028

   The Cleveland Clinic·Early Phase 1· NCT05025865· Registry history of NCT05025865 on ClinicalTrials.gov (opens the registry)

   Updated Sep 24, 2026

7. Notable

   HA35 Moderate Alcoholic Hepatitis (AH) Study

   Primary completion pushed from Oct 1, 2026 to Oct 1, 2028

   Also in this update: Study completion pushed from Oct 1, 2027 to Oct 1, 2028

   The Cleveland Clinic·Early Phase 1· NCT05018481· Registry history of NCT05018481 on ClinicalTrials.gov (opens the registry)

   Updated Sep 24, 2026

8. Notable

   Corneal Biomechanical Analysis Using Brillouin Microscopy

   Primary completion pushed from Jul 2026 to Jul 2027

   Also in this update: Study completion pushed from Dec 2026 to Dec 2027

   The Cleveland Clinic·Not specified· NCT04598932· Registry history of NCT04598932 on ClinicalTrials.gov (opens the registry)

   Updated Oct 1, 2026

9. Notable

   HMB Enriched Amino Acids to Reverse Muscle Loss in Cirrhosis

   Primary and study completion pushed from Dec 30, 2026 to Dec 30, 2028

   The Cleveland Clinic·Not applicable· NCT05166499· Registry history of NCT05166499 on ClinicalTrials.gov (opens the registry)

   Updated Sep 28, 2026

10. Notable

    Wearables-HF · Wearable Technology in Heart Failure Patients

    Primary completion pushed from Jun 2036 to Jun 2037

    Also in this update: Trial status changed: Recruiting → Not Yet Recruiting

    The Cleveland Clinic·Not specified· NCT07650669· Registry history of NCT07650669 on ClinicalTrials.gov (opens the registry)

    Updated Sep 28, 2026

11. Notable

    SUSIE · Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)

    Primary completion pushed from Jul 31, 2026 to Jan 31, 2027

    Also in this update: Study completion pushed from Dec 31, 2026 to Dec 31, 2027

    The Cleveland Clinic·Not specified· NCT04869813· Registry history of NCT04869813 on ClinicalTrials.gov (opens the registry)

    Updated Sep 28, 2026

12. Notable

    HMB-enriched Amino Acid Supplementation · Alcoholic Liver Disease…HMB-enriched Amino Acid Supplementation · Alcoholic Liver Disease and COVID-19

    Primary and study completion pushed from Dec 31, 2026 to Dec 31, 2028

    The Cleveland Clinic·Not applicable· NCT04858412· Registry history of NCT04858412 on ClinicalTrials.gov (opens the registry)

    Updated Sep 25, 2026

13. Notable

    Evening and Early Morning Protein Supplement to Reduce…Evening and Early Morning Protein Supplement to Reduce Readmissions for Hepatic Encephalopathy

    Primary completion pushed from Jun 30, 2026 to Jun 30, 2027

    Also in this update: Study completion pushed from Oct 30, 2026 to Oct 30, 2028

    The Cleveland Clinic·Not applicable· NCT04096014· Registry history of NCT04096014 on ClinicalTrials.gov (opens the registry)

    Updated Sep 25, 2026

14. Notable

    Peripheral Blood Mononuclear Cells Response In Healthy Controls…Peripheral Blood Mononuclear Cells Response In Healthy Controls, Heavy Drinkers, and · Alcoholic Hepatitis

    Primary and study completion pushed from Dec 2026 to Dec 31, 2028

    The Cleveland Clinic·Not specified· NCT04088370· Registry history of NCT04088370 on ClinicalTrials.gov (opens the registry)

    Updated Sep 24, 2026

15. Notable

    Novel Tracer Methods to Evaluate Muscle Protein Metabolism in…Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis

    Primary and study completion pushed from Sep 30, 2027 to Sep 30, 2028

    The Cleveland Clinic·Not specified· NCT03225677· Registry history of NCT03225677 on ClinicalTrials.gov (opens the registry)

    Updated Sep 24, 2026

16. Notable

    ConMICRO · Coronary Microvascular Dysfunction After STEMI Using…ConMICRO · Coronary Microvascular Dysfunction After STEMI Using Continuous Saline Thermodilution

    Enrollment reduced: 70 → 35 participants

    The Cleveland Clinic·Not specified· NCT06795035· Registry history of NCT06795035 on ClinicalTrials.gov (opens the registry)

    Updated Oct 1, 2026

17. Notable

    Parent-Mediated Telehealth Intervention for Insomnia in Young…Parent-Mediated Telehealth Intervention for Insomnia in Young Autistic Children

    Sponsor changed: Emory University to The Cleveland Clinic

    The Cleveland Clinic·Not applicable· NCT07435740· Registry history of NCT07435740 on ClinicalTrials.gov (opens the registry)

    Updated Oct 8, 2026

18. Notable

    Imaging in Semaglutide Study

    Recruitment opened

    The Cleveland Clinic·Not specified· NCT07695454· Registry history of NCT07695454 on ClinicalTrials.gov (opens the registry)

    Updated Oct 6, 2026

19. Notable

    Continuous Glucose Monitoring in Polycystic Ovarian Syndrome

    Enrollment reopened

    The Cleveland Clinic·Not specified· NCT07392476· Registry history of NCT07392476 on ClinicalTrials.gov (opens the registry)

    Updated Oct 6, 2026

• Stopped: an ongoing trial was terminated, suspended or withdrawn.
• Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
• Minor: routine progress and housekeeping, such as sites added or enrollment closed.