Disease landscape

Hypertension clinical trials

Get alerts when Hypertension trials change

1,376 active trials 721 recruiting 80 Phase 3 742 sponsors 197 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 54 of 197 changes on 20 trials

2026-09-04
Withdrawn before enrolling
Trial withdrawn: Funding not obtained
NCT06327373 A Feasibility Study of Supplemental Oxygen to Improve Pulmonary Hypertension in People… · Duke University · Phase 1/2
2026-09-03
Reclassified as terminated (was completed)
Trial terminated: Study completed
Results posted: 2026-09-02
NCT05700903 Contributions to Hypertension With Androgen Deprivation Therapy · University of Colorado, Denver · Phase 4
2026-08-29
Primary completion pushed: 2026-07-22 → 2027-07-22
Completion pushed: 2026-12-31 → 2027-12-31
NCT06555952 MegaNatural BP® GSE on Blood Pressure and Cardiometabolic Risk Factors · Clinical Nutrition Research Center, Illinois Institute of Technology
2026-08-25
Primary completion pushed: 2025-12 → 2026-06-09
Trial completed
Completion pushed: 2025-12 → 2026-06-09
NCT07117474 Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Single Subcutaneous… · Fujian Shengdi Pharmaceutical Co., Ltd. · Phase 1
2026-08-18
Primary completion pushed: 2027-04 → 2028-03
Phase changed: Phase 1 → Phase 1/2
Recruitment opened
Enrollment increased: 40 → 90 participants
Completion pushed: 2028-01 → 2028-11
NCT07143448 A Study of HS235 for Treatment of Pulmonary Arterial Hypertension (PAH) in Adults · 35Pharma Inc · Phase 1/2
2026-08-18
Primary completion pushed: 2027-09 → 2029-01
Phase changed: Phase 1 → Phase 1/2
Recruitment opened
Enrollment increased: 40 → 126 participants
Completion pushed: 2028-09 → 2030-01
NCT07123779 HS235 Study in Obese Participants With Pulmonary Hypertension and Heart Failure With… · 35Pharma Inc · Phase 1/2
2026-09-04
Primary completion pushed: 2026-08-31 → 2026-12-31
Completion pushed: 2026-08-31 → 2026-12-31
NCT04838678 Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN) · University of Texas Southwestern Medical Center · Early Phase 1
2026-09-05
Primary completion pushed: 2026-06 → 2027-01
Completion pushed: 2026-12 → 2027-06
NCT06823115 Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0 · Indiana University
2026-08-15
Primary completion pushed: 2025-03-31 → 2025-10-31
Sponsor changed: Novartis → Novartis Pharmaceuticals
Trial completed
Completion pushed: 2025-03-31 → 2025-10-31
NCT06604897 Effectiveness of Entresto (Sacubitril/Valsartan) in Japanese Patients With Hypertension · Novartis Pharmaceuticals
2026-08-11
Primary completion pushed: 2026-06-18 → 2027-03-31
Completion pushed: 2029-03-20 → 2029-12-31
NCT06526858 Early Feasibility Study of "HyperQureTM RDN System", Laparoscopic Renal Denervation… · DeepQure Inc.
2026-09-01
Primary completion pushed: 2027-05 → 2027-11
Completion pushed: 2027-05 → 2027-11
NCT07206303 The Effects of Bifidobacterium-based Probiotics in Reducing Blood Pressure in Middle-aged… · The University of Hong Kong · Phase 1
2026-09-01
Primary completion pushed: 2025-12 → 2026-12-31
Trial status changed: Not Yet Recruiting → Active, Not Recruiting
Trial sites expanded: 0 → 3 locations
Completion pushed: 2026-06 → 2027-06
NCT06920355 Community Pharmacy Produce Prescriptions · Tufts University
2026-08-28
Primary completion pushed: 2026-07 → 2028-07
Completion pushed: 2026-08 → 2028-08
NCT02425566 Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension · Vanderbilt University · Phase 1
2026-08-29
Primary completion pushed: 2025-12-31 → 2028-12-31
NCT04319068 Sodium Storage in Singaporeans · Jens Titze
2026-08-15
Primary completion pushed: 2026-08-01 → 2028-08-01
Completion pushed: 2026-08-01 → 2028-08-01
NCT03630211 Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis · Paul Szabolcs · Phase 2
2026-08-08
Primary completion pushed: 2027-01 → 2028-01
Primary endpoint(s) modified
Enrollment closed, study ongoing
Enrollment increased: 40 → 70 participants
Completion pushed: 2027-01 → 2028-01
Trial arms changed: 2 → 3
NCT05825417 Pulmonary Hypertension: Intensification and Personalisation of Combination Rx · Sheffield Teaching Hospitals NHS Foundation Trust · Phase 4
2026-08-26
Primary completion pushed: 2026-06-30 → 2026-09-30
NCT04626245 Mindfulness & Mechanisms Study · Lifespan
2026-09-05
Primary endpoint(s) modified
Trial completed
NCT05888233 Allopurinol Improves Heart Function in African Americans With Resistant Hypertension · VA Office of Research and Development · Phase 2
2026-08-26
Primary completion pushed: 2026-06-30 → 2026-12-31
Completion pushed: 2026-12-31 → 2027-07-31
NCT06804122 Exercise-based Rehabilitation in Patients With Pulmonary Arterial Hypertension · Tampere Heart Hospital
2026-08-26
Primary completion pushed: 2031-06-30 → 2032-06-30
Completion pushed: 2031-06-30 → 2032-06-30
NCT05992415 Know Your Pressures NYC · Columbia University

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-04 NCT07803835 Phase 1 Clinical Study of MWX401 Injection in Chinese Healthy Participants and… Shanghai Minwei Biotechnology Co., Ltd new Phase 1
2026-09-03 NCT07801599 Huayu Jiedu Formula (FTFY-919) Granules Versus Traditional Decoction for Acute… Guangzhou University of Traditional Chinese Medicine new Phase 3
2026-09-02 NCT07799961 Arizona CEAL: Linking Social Care With Healthcare Systems to Address SDOH Sairam Parthasarathy new
2026-09-02 NCT07799675 Telerehabilitation in Pulmonary Arterial Hypertension Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud new
2026-08-27 NCT07789535 Sleep and Arterial Function in Hypertensive Patients With Poor Sleep Quality Unidade Local de Saúde do Alto Ave, EPE new
2026-08-26 NCT07787936 GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry Miedziowe Centrum Zdrowia SA new
2026-08-24 NCT07783061 Reducing Cardiovascular Risks: The Role of Alcohol Use The University of Texas at Arlington new
2026-08-21 NCT07780500 REFOCUS-HTN US-WEST: A Data Infrastructure to Characterize Individuals With Hypertension Kaiser Permanente new
2026-08-19 NCT07773272 Cardiovascular-kidney-metabolic (CKM)-Guided Therapy for Patients After Acute Coronary… Zuyderland Medisch Centrum new
2026-08-18 NCT07771504 Health Coaching Added to Standard Therapy for Hypertension: Blood Pressure and Quality of… Indonesia University new

Active trials by phase

Early Phase 1
17
Phase 1
52
Phase 1/2
21
Phase 2
74
Phase 2/3
6
Phase 3
74
Phase 4
64
Not charted: 1,068 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 1,376

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT04715568 Secondhand Tobacco Smoke and Cardiovascular Disease University of California, San Francisco Recruiting 2026-08-19
NCT07322133 Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE) University of California, Davis Recruiting 2026-08-18
NCT07713914 Randomized Study of Triple Therapy vs Sildenafil Dose Optimization in Pulmonary Arterial… University of Sao Paulo General Hospital Recruiting 2026-07-30
NCT07140484 Sotatercept in Pulmonary Arterial Hypertension University of Alberta Recruiting 2026-07-09
NCT06915792 PEACE Trial: Postpartum Evaluation of Antihypertensive Cessation and Efficacy University of California, Los Angeles Recruiting 2026-06-05
NCT06281665 Treatment With Aspirin After Preeclampsia: TAP Trial Malamo Countouris Recruiting 2026-06-04
NCT07607275 Effect of the Traditional Chinese Medicine Yufeng Ningxin in Patients With Hypertension Beijing Anzhen Hospital Recruiting 2026-06-02
NCT07617376 Pre-discharge Influenza Vaccination in Patients Hospitalized for Acute Cardiac Conditions Wroclaw Medical University Recruiting 2026-06-01
NCT06468202 Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy… Ohio State University Recruiting 2026-05-04
NCT05593055 Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in… Brigham and Women's Hospital Recruiting 2026-04-06
NCT07147114 Clinical Trial to Evaluate the Efficacy and Safety in Concomitant Administration of… Gachon University Gil Medical Center Recruiting 2026-04-03
NCT04454203 Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter… Duke University Recruiting 2026-03-23
NCT06246396 Antihypertensive Mechanisms of Minocycline in Resistant Hypertension University of Florida Recruiting 2026-03-06
NCT06055452 Effects of SGLT2 Inhibitors in Pre-heart Failure Populations With Hypertension China National Center for Cardiovascular Diseases Recruiting 2026-03-05
NCT06785116 A Randomized, Placebo-controlled Trial of DAPAgliflozin (DAPA) for Cardiovascular Risk… University of Michigan Recruiting 2026-03-04
NCT07359599 The Impact of IV Iron on Exercise Capacity and Quality of Life in Pulmonary Hypertension Ziekenhuis Oost-Limburg Recruiting 2026-01-30
NCT07361679 LDA and LMWH vs LDA Alone in High-risk Patients for Preeclampsia Prevention Alexandra Hospital, Athens, Greece Recruiting 2026-01-23
NCT06132477 Impact GLP-1 Agonists Following Bariatric University of Missouri-Columbia Recruiting 2026-01-22
NCT07356778 A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired… Kazuya Hosokawa Recruiting 2026-01-21
NCT06256991 Potassium Correction for RAAS Optimization in Chronic Kidney Disease University Medical Center Groningen Recruiting 2025-12-19
NCT06834230 Effect of Dotinurad in Hyperuricemia With Hypertension Saga University Recruiting 2025-12-15
NCT07271420 Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis Patients Chinese University of Hong Kong Recruiting 2025-12-09
NCT07023003 Postpartum Evaluation of Nifedipine and Enalapril for Hypertension Nebraska Methodist Health System Recruiting 2025-10-22
NCT06632379 AtorvaStatin Postpartum and Reduction of Cardiovascular risK Ohio State University Recruiting 2025-10-20
NCT06658522 Right Ventricular Compensation With Sotatercept: A Prospective Single Arm Open Label… Amsterdam UMC, location VUmc Recruiting 2025-09-22
See all 1,376 active Hypertension trials with filters →

Top sponsors by active trials in this area

University of Alabama at Birmingham (21) · Vanderbilt University Medical Center (18) · Johns Hopkins University (13) · Mayo Clinic (12) · Assistance Publique - Hôpitaux de Paris (11) · China National Center for Cardiovascular Diseases (11) · Duke University (11) · University of Sao Paulo General Hospital (11) · Assiut University (10) · Brigham and Women's Hospital (9)

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