Disease landscape

Depression clinical trials

Get alerts when Depression trials change

2,090 active trials 1,170 recruiting 91 Phase 3 971 sponsors 345 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 55 of 345 changes on 20 trials

2026-09-03
Withdrawn before enrolling
Trial withdrawn: The collaborator could not proceed with the study due to personnel changes.
NCT07058532 Therapeutic Writing for Adults Suffering From Chronic Pain and Comorbid Mental Health… · Toni Salikka
2026-08-28
Withdrawn before enrolling
Trial withdrawn: unable to obtain equipment needed for study
Enrollment reduced: 25 → 0 participants
NCT07553364 Auditory Stimulation for Insomnia and Depression · Wake Forest University Health Sciences
2026-08-13
Trial terminated
Trial terminated: Lack of funding
Enrollment reduced: 50 → 1 participants
Primary completion moved earlier: 2026-12 → 2026-07-01
Completion moved earlier: 2026-12 → 2026-07-15
NCT05803551 A Study of Ketamine Infusions to Treat Clinically-depressed ICU Patients · Mayo Clinic · Phase 2
2026-08-12
Trial terminated
Trial terminated: The study was terminated due to limited resources and the loss of key study personnel, which made completion of the pla...
Enrollment reduced: 60 → 14 participants
Primary completion moved earlier: 2028-04 → 2023-12-31
Completion moved earlier: 2028-12 → 2023-12-31
NCT05388110 SKY Breath Intervention · University of California, San Francisco
2026-08-11
Trial status changed: Completed → Terminated
Trial terminated: Recruitment halted prematurely due to recruitment timing and resources for the study not aligning.
NCT05619510 Pain Reduction Through Empowered Recovery (PRIME) Study · Johns Hopkins University
2026-09-02
Primary completion pushed: 2029-07-31 → 2029-12-31
Completion pushed: 2030-03-31 → 2030-08-30
NCT07202325 Self-Help Intervention for Post 9/11 Veterans With Depression or PTSD Symptoms · VA Office of Research and Development
2026-09-04
Primary completion pushed: 2026-06-30 → 2027-06-30
Completion pushed: 2026-06-30 → 2027-06-30
NCT06759558 Allopregnanolone (Zuranolone) in Post-stroke Depression · Duke University · Phase 2
2026-08-27
Primary completion pushed: 2025-10 → 2026-01-31
Completed without a posted recruiting period
Completion pushed: 2025-10 → 2026-01-31
NCT07081061 Clinical Outcomes of a Digital Mental Health Intervention for Moderate/Severe Depression… · Teladoc Health
2026-09-05
Primary completion pushed: 2026-09-30 → 2027-06-30
Completion pushed: 2026-12-31 → 2027-09-30
NCT04123314 Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's… · Johns Hopkins University · Early Phase 1
2026-09-05
Primary completion pushed: 2026-09-30 → 2026-12-30
NCT06355414 Psilocybin in Chronic Low Back Pain and Depression · Johns Hopkins University · Phase 1
2026-08-25
Primary completion pushed: 2027-12 → 2029-01
Primary endpoint(s) modified
Completion pushed: 2028-01 → 2029-03
NCT07282678 Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Major… · Pulvinar Neuro, LLC
2026-09-05
Primary completion pushed: 2027-06 → 2028-02
Primary endpoint(s) modified
Enrollment reduced: 240 → 160 participants
Recruitment opened
Interventions modified
Completion pushed: 2027-12 → 2028-06
NCT07334561 Transcranial Electrical Stimulation for Comorbid Depression and Chronic Pain · Shanghai Mental Health Center
2026-09-05
Primary completion pushed: 2026-08-30 → 2026-12-28
Enrollment closed, study ongoing
Completion pushed: 2026-10-01 → 2026-12-30
NCT07226011 Accelerated High-Dose tDCS for Depression · Medical University of South Carolina
2026-09-04
Primary completion pushed: 2027-12-01 → 2028-12-01
Completion pushed: 2028-12-01 → 2029-12-01
NCT05437705 Decoding and Modulating Affective Brain States · University of Pennsylvania
2026-09-04
Primary completion pushed: 2026-06 → 2026-10
Completion pushed: 2027-02 → 2027-06
NCT06587230 Teachers Leading the Front Lines - North Carolina (Tealeaf-NC) · University of North Carolina, Chapel Hill
2026-09-04
Primary completion pushed: 2026-08-31 → 2027-08-31
Completion pushed: 2026-08-31 → 2027-08-31
NCT06143293 RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKS · University of Minnesota
2026-08-15
Primary completion pushed: 2025-10 → 2026-02-28
Trial completed
Enrollment increased: 1000 → 1600 participants
Completion pushed: 2025-11 → 2026-02-28
NCT06809907 Kintsugi Voice Device Pivotal Study · Kintsugi Mindful Wellness, Inc.
2026-08-08
Primary completion pushed: 2025-12-31 → 2027-12-31
Completion pushed: 2025-12-31 → 2027-12-31
NCT04011163 Vital Signs-Integrated Patient-Assisted Intravenous Opioid Analgesia for Post Surgical… · KK Women's and Children's Hospital · Phase 2/3
2026-08-28
Primary completion pushed: 2025-02 → 2030-09
Completion pushed: 2025-02 → 2030-12
NCT04569448 Brexpiprazole Treatment for Bipolar I Depression · Douglas Mental Health University Institute · Phase 3
2026-09-03
Primary completion pushed: 2026-09-01 → 2028-05-31
Completion pushed: 2026-12-31 → 2028-06-30
NCT06450704 Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive… · Fundación de Investigación Biomédica - Hospital Universitario de La Princesa

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-04 NCT07804459 Individualized fMRI-guided TMS for Depression Desmond Oathes new Early Phase 1
2026-09-04 NCT07804979 Comparison of Efficacy of Minocyclin and Celecoxib as Adjunctive Treatment in Treatment… Lahore General Hospital new
2026-08-31 NCT07793981 Clinical Evaluation of an Alarm Activated Detection System to Enable Early Intervention… Linshom Medical, Inc. new
2026-08-27 NCT07790627 Effect of Utilizing Virtual Reality With Pulmonary Rehabilitation on Depression in COPD… Imam Abdulrahman Bin Faisal University new
2026-08-27 NCT07790055 The Effect of Mindfulness in Inflammation Markers (IL-6, TNF-A, CRP and Cortisol) Among… Natalia Dewi Wardani, MD new
2026-08-27 NCT07790731 Using a School-Based Depression Literacy Psychoeducation Program With AI Chatbot to… Chang Hsiu-Ju new
2026-08-26 NCT07787845 The Goal is to Examine the Impact of Doula-coordinated, Midwife-delivered Postpartum Care… University of South Carolina new
2026-08-25 NCT07786285 Adjunctive Probiotic Therapy in Major Depressive Disorder (ProMOOD) University Maribor new
2026-08-24 NCT07781293 Study of Lurasidone as Adjunctive Treatment in Patients With Major Depressive Disorder… Bukwang Pharmaceutical new Phase 3
2026-08-21 NCT07780695 Effect of Adapted Physical Activity on Emotion Regulation in People With Depressive… Centre Hospitalier Georges Mazurelle new

Active trials by phase

Early Phase 1
18
Phase 1
36
Phase 1/2
27
Phase 2
144
Phase 2/3
17
Phase 3
74
Phase 4
75
Not charted: 1,699 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 2,090

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06103760 Positioning of Esketamine Treatment in the Real-world Management of Depression Royal North Shore Hospital Recruiting 2026-08-12
NCT07552246 Comparing Acupuncture With Medication to Reduce Depression, Anxiety and Comorbid Sleep… Duke Kunshan University Recruiting 2026-07-29
NCT06833788 Treatment of Anaemia After Caesarean With Intravenous Versus Oral Iron and Postpartum… Assistance Publique - Hôpitaux de Paris Recruiting 2026-06-23
NCT07266545 RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression… Mayo Clinic Recruiting 2026-06-22
NCT07105111 A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive… Neurocrine Biosciences Recruiting 2026-06-16
NCT05017311 Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D) Nova Scotia Health Authority Recruiting 2026-06-11
NCT06278779 Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant… The George Institute Recruiting 2026-05-29
NCT05976347 Identifying and Treating Depression in the Orthopaedic Trauma Population Wake Forest University Health Sciences Recruiting 2026-05-22
NCT04400266 Buspirone and Melatonin for Depression Following Traumatic Brain Injury Massachusetts General Hospital Recruiting 2026-05-06
NCT05004987 Aβ Dynamics in LLMD NYU Langone Health Recruiting 2026-05-06
NCT06748209 Establishing Mobile Transcranial Magnetic Stimulation Medical University of South Carolina Recruiting 2026-05-06
NCT07432815 Treatment of Psoriasis With Depression and/or Anxiety With Methotrexate vs Combined… Cairo University Recruiting 2026-05-05
NCT05892744 Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression University of Texas at Austin Recruiting 2026-05-01
NCT05282277 Examining the Effects of Estradiol on Neural and Molecular Response to Reward University of North Carolina, Chapel Hill Recruiting 2026-04-29
NCT07080723 Algorithm Guided Treatment Versus Treatment as Usual (TAU) for Patients With Treatment… Aalborg University Hospital Recruiting 2026-04-27
NCT06903819 Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients Texas Tech University Health Sciences Center Recruiting 2026-03-24
NCT07478796 TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children Poznan University of Medical Sciences Recruiting 2026-03-18
NCT05851898 Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following… Wake Forest University Health Sciences Recruiting 2026-03-12
NCT07076342 The Role of mGluR5 in CBT-I Stony Brook University Recruiting 2026-02-17
NCT07136714 Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder… Nordsjaellands Hospital Recruiting 2026-02-06
NCT06075771 Dopaminergic Therapy for Anhedonia - 2 Emory University Recruiting 2026-01-28
NCT07369102 Esketamine With or Without Integration Therapy for Treatment-Resistant Depression University of Puerto Rico Recruiting 2026-01-27
NCT05913947 Lithium Versus Cariprazine in the Acute Phase Treatment of Bipolar Depression (DUAG9) Aalborg University Hospital Recruiting 2026-01-21
NCT07182890 Efficacy of Clostridium Butyricum in Alleviating Anxiety and Depression in Patients With… Xijing Hospital of Digestive Diseases Recruiting 2026-01-05
NCT07187492 Efficacy of Bacillus Coagulans in Alleviating Anxiety and Depression in Patients With… Xijing Hospital of Digestive Diseases Recruiting 2026-01-05
See all 2,090 active Depression trials with filters →

Top sponsors by active trials in this area

Massachusetts General Hospital (40) · Stanford University (25) · Medical University of South Carolina (24) · VA Office of Research and Development (21) · Centre for Addiction and Mental Health (20) · University of California, Los Angeles (18) · Weill Medical College of Cornell University (18) · Shanghai Mental Health Center (16) · Washington University School of Medicine (16) · University of California, San Diego (15)

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