VA Office of Research and Development clinical trial pipeline

61 trials changed in the last 30 days: 1 stopped, 38 with notable changes, 22 with minor changes only.

1. Stopped

   AMD · Rehabilitating Vision Loss in Veterans With Age-Related…AMD · Rehabilitating Vision Loss in Veterans With Age-Related Macular Degeneration

   Withdrawn before enrolling

   Sponsor's reason: I was instructed to stop the study, because the underlying VA grant has run out of funds.

   Also in this update: Primary completion date changed from estimate of May 31, 2027 to Sep 29, 2026; Start date changed from estimate of Oct 1, 2026 to Jan 1, 2024

   VA Office of Research and Development·Not specified· NCT05780931· Registry history of NCT05780931 on ClinicalTrials.gov (opens the registry)

   Updated Oct 5, 2026

2. Notable

   Improving Rehabilitation for Veterans After Total Knee…Improving Rehabilitation for Veterans After Total Knee Arthroplasty Using Individualized Recovery Trajectories

   Primary completion pushed from Sep 30, 2026 to Mar 31, 2027

   Also in this update: Completion pushed from Mar 31, 2027 to Jun 30, 2027

   VA Office of Research and Development·Not specified· NCT05288803· Registry history of NCT05288803 on ClinicalTrials.gov (opens the registry)

   Updated Oct 8, 2026

3. Notable

   NightWare and Cardiovascular Health in Veterans With PTSD

   Primary completion pushed from Sep 30, 2026 to Sep 30, 2027

   Also in this update: Completion pushed from Dec 31, 2026 to Dec 31, 2027

   VA Office of Research and Development·Not applicable· NCT06419959· Registry history of NCT06419959 on ClinicalTrials.gov (opens the registry)

   Updated Oct 8, 2026

4. Notable

   HearVA-ED · Hearing Impairment, Strategies and Outcomes in VA…HearVA-ED · Hearing Impairment, Strategies and Outcomes in VA Emergency Departments

   Primary and study completion pushed from Sep 30, 2026 to Mar 31, 2027

   Also in this update: Primary endpoint(s) modified

   VA Office of Research and Development·Not applicable· NCT05028972· Registry history of NCT05028972 on ClinicalTrials.gov (opens the registry)

   Updated Oct 5, 2026

5. Notable

   Leg Stretching Using an Exoskeleton on Demand · Spasticity

   Primary completion pushed from Sep 30, 2026 to Apr 30, 2027

   Also in this update: Completion pushed from Oct 30, 2026 to Apr 30, 2027

   VA Office of Research and Development·Not applicable· NCT05926596· Registry history of NCT05926596 on ClinicalTrials.gov (opens the registry)

   Updated Oct 2, 2026

6. Notable

   Acceptability and Feasibility of Work-Oriented Social-Cognitive…Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness

   Primary completion pushed from Nov 27, 2026 to Nov 26, 2027

   Also in this update: Completion pushed from Nov 30, 2027 to Nov 30, 2028

   VA Office of Research and Development·Not applicable· NCT05491538· Registry history of NCT05491538 on ClinicalTrials.gov (opens the registry)

   Updated Oct 2, 2026

7. Notable

   Improving Measurement and Treatment of Post-stroke Neglect

   Primary and study completion pushed from Sep 30, 2026 to Sep 30, 2027

   VA Office of Research and Development·Not applicable· NCT03317860· Registry history of NCT03317860 on ClinicalTrials.gov (opens the registry)

   Updated Oct 2, 2026

8. Notable

   VA-BAT · High Dose Testosterone for ATM, CDK12 or CHEK2…VA-BAT · High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers

   Primary completion pushed from Aug 31, 2026 to Aug 3, 2027

   VA Office of Research and Development·Phase 2· NCT05011383· Registry history of NCT05011383 on ClinicalTrials.gov (opens the registry)

   Updated Sep 17, 2026

9. Notable

   COPE-VA · Outcomes and Pharmacotherapy Effectiveness in the VA…COPE-VA · Outcomes and Pharmacotherapy Effectiveness in the VA Health Care System (COPE-VA)

   Primary completion pushed from Sep 30, 2026 to Sep 30, 2027

   VA Office of Research and Development·Not specified· NCT06160128· Registry history of NCT06160128 on ClinicalTrials.gov (opens the registry)

   Updated Sep 30, 2026

10. Notable

    Functional and Neuroprotective Effects of Restoring Lower Limb…Functional and Neuroprotective Effects of Restoring Lower Limb Sensation After Diabetic Peripheral Neuropathy

    Primary and study completion pushed from Oct 1, 2026 to Oct 1, 2027

    VA Office of Research and Development·Not applicable· NCT04658693· Registry history of NCT04658693 on ClinicalTrials.gov (opens the registry)

    Updated Sep 30, 2026

11. Notable

    CS · Reliability and Validity of Continuous Inter-limb Stability

    Primary completion pushed from Sep 30, 2026 to Sep 30, 2027

    Also in this update: Completion pushed from Dec 31, 2026 to Dec 31, 2027

    VA Office of Research and Development·Not applicable· NCT06987019· Registry history of NCT06987019 on ClinicalTrials.gov (opens the registry)

    Updated Sep 30, 2026

12. Notable

    VC-OPTIONS · Developing an Intervention to Optimize Virtual Care…VC-OPTIONS · Developing an Intervention to Optimize Virtual Care Adoption for COPD Management

    Primary completion pushed from Aug 31, 2027 to Aug 31, 2028

    VA Office of Research and Development·Not applicable· NCT05986214· Registry history of NCT05986214 on ClinicalTrials.gov (opens the registry)

    Updated Sep 29, 2026

13. Notable

    T2CR · Transition to Cardiac Rehabilitation (T2CR) to Address…T2CR · Transition to Cardiac Rehabilitation (T2CR) to Address Barriers of Multimorbidity and Frailty

    Primary completion pushed from Mar 31, 2027 to Dec 31, 2027

    Also in this update: Completion pushed from Aug 31, 2027 to Dec 31, 2027

    VA Office of Research and Development·Not applicable· NCT06244199· Registry history of NCT06244199 on ClinicalTrials.gov (opens the registry)

    Updated Sep 29, 2026

14. Notable

    TEACH-VET · Comprehensive Pre-ESKD Education on Home Dialysis…TEACH-VET · Comprehensive Pre-ESKD Education on Home Dialysis Use in Veterans

    Primary completion pushed from Sep 30, 2025 to Dec 31, 2026

    VA Office of Research and Development·Not applicable· NCT04064086· Registry history of NCT04064086 on ClinicalTrials.gov (opens the registry)

    Updated Sep 15, 2026

15. Notable

    EMPOWER · Enhancing Mental and Physical Health of Women Veterans

    Primary completion pushed from Sep 30, 2025 to Oct 30, 2026

    Also in this update: Completion pushed from Sep 30, 2026 to Oct 30, 2026

    VA Office of Research and Development·Not applicable· NCT05050266· Registry history of NCT05050266 on ClinicalTrials.gov (opens the registry)

    Updated Sep 14, 2026

16. Notable

    RAPID5 · Rapid Acceleration Process for Intensive Treatment of…RAPID5 · Rapid Acceleration Process for Intensive Treatment of PTSD in 5 Days

    Primary endpoint(s) modified

    VA Office of Research and Development·Phase 3· NCT07167940· Registry history of NCT07167940 on ClinicalTrials.gov (opens the registry)

    Updated Oct 5, 2026

17. Notable

    Patient-driven Management of BP in CKD

    Primary endpoint(s) modified

    Also in this update: Enrollment closed, study ongoing; Primary completion pushed from Sep 30, 2026 to Dec 15, 2026

    VA Office of Research and Development·Phase 3· NCT05546099· Registry history of NCT05546099 on ClinicalTrials.gov (opens the registry)

    Updated Oct 2, 2026

18. Notable

    VNS in PTSD · Transcutaneous Vagal Nerve Stimulation in Veterans…VNS in PTSD · Transcutaneous Vagal Nerve Stimulation in Veterans With Posttraumatic Stress Disorder

    Primary endpoint(s) modified

    Also in this update: Interventions modified

    VA Office of Research and Development·Not applicable· NCT05517304· Registry history of NCT05517304 on ClinicalTrials.gov (opens the registry)

    Updated Oct 7, 2026

19. Notable

    Combining a Smartphone App With Medications to Manage Heavy…Combining a Smartphone App With Medications to Manage Heavy Drinking

    Primary endpoint(s) modified

    VA Office of Research and Development·Not applicable· NCT06303778· Registry history of NCT06303778 on ClinicalTrials.gov (opens the registry)

    Updated Oct 7, 2026

20. Notable

    Kinematic and Neural Dynamics of Postural Instability in…Kinematic and Neural Dynamics of Postural Instability in Parkinson's Disease

    Primary endpoint(s) modified

    VA Office of Research and Development·Not specified· NCT06405334· Registry history of NCT06405334 on ClinicalTrials.gov (opens the registry)

    Updated Oct 6, 2026

• Stopped: an ongoing trial was terminated, suspended or withdrawn.
• Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
• Minor: routine progress and housekeeping, such as sites added or enrollment closed.