Homeless Overdose Prevention- Expansion

Homeless Overdose Prevention - Expansion (HOPE), tests implementation of overdose education and naloxone distribution (OEND), a program that targets homeless experienced Veterans at risk for overdose, including Veterans in community-based supportive housing. HOPE sites will receive a playbook that offers step-by-step instructions, tools, templates, and checklists tailorable to site needs; sites will also receive performance feedback about their performance relative to a standard or benchmark.

NCT Number	NCT07716202
Lead Sponsor	VA Office of Research and Development
Conditions	Homelessness, Opioid Education and Naloxone Distribution (OEND), Substance Use Disorder
Enrollment	1,200 participants
Start Date	2026-08-31
Primary Completion	2030-07-31 (estimated)
Study Completion	2030-09-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-30