Disease landscape

PTSD clinical trials

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608 active trials 374 recruiting 22 Phase 3 329 sponsors 95 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-16

What changed in the last 30 days showing 43 of 95 changes on 20 trials

2026-08-20
Primary completion pushed: 2026-12-31 → 2027-03-31
Completion pushed: 2026-12-31 → 2027-03-31
NCT06044675 MDMA-Assisted CBCT for PTSD vs CBCT RCT · Remedy · Phase 2
2026-08-20
Primary completion pushed: 2026-07-06 → 2027-03-31
Completion pushed: 2027-03-31 → 2027-09-30
NCT05776056 Methylphenidate for the Treatment of PTSD With Associated Neurocognitive Complaints · VA Office of Research and Development · Phase 4
2026-08-20
Primary completion pushed: 2026-03 → 2028-03
Completion pushed: 2026-03 → 2028-03-01
NCT05790239 MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder · Stephen Robert Marder · Phase 2
2026-09-12
Primary completion pushed: 2026-07 → 2027-06
Completion pushed: 2026-07 → 2027-06
NCT07079839 A Neurosensory Account of Anxiety and Stress (Study 2) · The University of Texas Health Science Center, Houston
2026-09-12
Primary completion pushed: 2025-07-01 → 2027-04-30
Enrollment reopened
Interventions modified
Completion pushed: 2026-11-01 → 2027-04-30
NCT05541406 Efficacy of a Multi-level School Intervention for LGBTQ Youth · Washington University School of Medicine
2026-09-11
Primary completion pushed: 2025-12-31 → 2027-05-26
Recruitment opened
Completion pushed: 2025-12-31 → 2027-05-26
NCT06996275 Attachment and Post-Traumatic Stress Disorder in Military Personnel: Characterization of… · Direction Centrale du Service de Santé des Armées
2026-09-11
Primary completion pushed: 2026-06 → 2027-02
Completion pushed: 2026-07 → 2027-07
NCT06648928 Clinician Supported Mobile App to Reduce Mental Health Symptoms Among World Trade Center… · Florida International University
2026-09-09
Primary completion pushed: 2027-06-01 → 2027-09-01
Recruitment opened
Completion pushed: 2027-06-01 → 2027-09-01
NCT07540585 MOCHA: Embedded Inpatient Mental Health Care for High-Risk Perinatal Patients · Indiana University
2026-09-02
Primary completion pushed: 2029-07-31 → 2029-12-31
Completion pushed: 2030-03-31 → 2030-08-30
NCT07202325 Self-Help Intervention for Post 9/11 Veterans With Depression or PTSD Symptoms · VA Office of Research and Development
2026-09-03
Primary completion pushed: 2027-04-10 → 2028-06-10
Recruitment opened
Interventions modified
Completion pushed: 2027-07-30 → 2028-07-30
NCT07495917 Tetris Intervention Following Subliminal Reactivation for Intrusive Memories · Shaanxi Normal University
2026-09-01
Primary completion pushed: 2026-06-30 → 2027-05-31
Completion pushed: 2026-06-30 → 2027-05-31
NCT05120635 Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans · Duke University
2026-08-28
Primary completion pushed: 2027-07 → 2028-07
Completion pushed: 2027-08 → 2028-08
NCT06296186 Massed Prolonged Exposure for PTSD in Substance Use Treatment · Veterans Medical Research Foundation
2026-08-25
Primary completion pushed: 2026-07-07 → 2029-04-30
Completion pushed: 2026-07-07 → 2029-04-30
NCT01044160 Stress, Adjustment And Growth In Children With Cancer And Their Parents · St. Jude Children's Research Hospital
2026-08-21
Primary completion pushed: 2026-07-31 → 2028-01-01
Completion pushed: 2026-07-31 → 2028-01-01
NCT03932773 Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD · The University of Texas at Dallas
2026-08-20
Primary completion pushed: 2026-06-30 → 2027-07-31
Completion pushed: 2026-06-30 → 2027-07-31
NCT06093906 Positive Processes and Transition to Health (PATH) · Case Western Reserve University
2026-09-15
Primary endpoint(s) modified
Completion pushed: 2026-09-30 → 2027-09-30
NCT00748995 Neuropsychological and Mental Outcomes of Operation Iraqi Freedom (OIF): A Longitudinal… · VA Office of Research and Development
2026-09-09
Primary endpoint(s) modified
NCT06820138 Focused Ultrasound for PTSD in Veterans · VA Office of Research and Development · Phase 2
2026-09-16
Primary endpoint(s) modified
NCT07498257 Examining Written Exposure Therapy Delivered to Adolescents · Medical University of South Carolina
2026-09-04
Primary endpoint(s) modified
NCT07105345 Exploring Efficacy of Multi-Mode Cognitive Processing Therapy (CPT) for PTSD · Far Eastern Memorial Hospital
2026-08-28
Enrollment reduced: 100 → 90 participants
Enrollment closed, study ongoing
NCT05683132 Treatments in Women Veterans With Insomnia and PTSD · VA Office of Research and Development

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-10 NCT07813962 Dexmedetomidine Combined With Transcutaneous Vagus Nerve Stimulation (taVNS) Can Reduce… Affiliated Hospital of Nantong University new
2026-09-10 NCT07812987 Rapid Entrainment and Signal-guided Neuromodulation for Behavioral Health Tactical Mind Research Coalition, Inc. new
2026-09-03 NCT07802158 Discontinuing Psychotropic Medication Before Psychotherapy for PTSD Academic Centre for Dentistry in Amsterdam new
2026-09-03 NCT07801534 Comparative Efficacy of Cognitive Behavioral and Mindfulness Therapies in Reducing… GIFT University new
2026-09-01 NCT07796919 The Effect of Mindfulness in Inflammation Markers (MLR, NLR, PLR), Stress, Anxiety, and… Natalia Dewi Wardani, MD new
2026-08-24 NCT07783516 Grappling With Trauma: Brazilian Jiu-Jitsu for First Responders Sam Houston State University new
2026-08-24 NCT07781904 Psychoeducation-Supported Breathing and Relaxation for Earthquake Survivors Rana Ceviz new
2026-08-20 NCT07775677 IPV Prevention Among FDP George Mason University new
2026-08-20 NCT07776769 EMDR Grief Protocol for Traumatic Grief After Earthquake-Related Loss Istanbul Bilgi University new
2026-08-19 NCT07773935 ONE-P TMS First Responders Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA new Phase 2

Active trials by phase

Early Phase 1
10
Phase 1
13
Phase 1/2
4
Phase 2
65
Phase 2/3
7
Phase 3
15
Phase 4
13
Not charted: 481 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 608

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT05776056 Methylphenidate for the Treatment of PTSD With Associated Neurocognitive Complaints VA Office of Research and Development Recruiting 2026-08-19
NCT06573970 Atomoxetine and Executive Function in PTSD VA Office of Research and Development Recruiting 2026-07-07
NCT06852469 Computational Assessment of GABA Receptor Modulation in PTSD VA Office of Research and Development Recruiting 2026-06-16
NCT07382596 Cervical Plexus Hydrodissection With D5W Versus NS for Treatment-Resistant PTSD Dr. Dean Reeves Clinic Recruiting 2026-05-19
NCT05853627 Mismatch vs. Standard Intervention During Memory Reconsolidation Blockade With… Massachusetts General Hospital Recruiting 2026-05-06
NCT06903819 Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients Texas Tech University Health Sciences Center Recruiting 2026-03-24
NCT03642028 Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance in… VA Office of Research and Development Recruiting 2025-07-18
NCT06414356 The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD Margaux M. Salas, PhD Recruiting 2025-02-25
NCT07686731 Suvorexant 3 - PE-PC Northern California Institute of Research and Education Not Yet Recruiting 2026-07-07
NCT04961190 A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for… University of Pennsylvania Active, Not Recruiting 2026-06-09
NCT06788522 The Effects of Orexin Antagonism on Fear Extinction in PTSD VA Office of Research and Development Not Yet Recruiting 2026-06-02
NCT05391971 Effects of Stellate Ganglion Block in Post-traumatic Stress Disorder NYU Langone Health Active, Not Recruiting 2026-04-09
NCT07192536 Accelerated Neuromodulation for Concurrent Post-Traumatic Stress Disorder (PTSD) &… Legion Veterans Village Research Foundation Not Yet Recruiting 2025-11-18
Phase 3
NCT07703722 Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis… Khyber Medical University Peshawar Recruiting 2026-07-14
NCT07456696 An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1) Transcend Therapeutics Recruiting 2026-06-12
NCT07280065 REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool Senseye, Inc. Recruiting 2026-04-29
NCT04877093 Repurposing Low-Dose Clonidine for PTSD in Veterans Wake Forest University Health Sciences Recruiting 2026-03-31
NCT06412757 Silexan in the Treatment Of Posttraumatic Stress Disorder Trial Deakin University Recruiting 2025-12-18
NCT06394284 Examining 3,4-methylenedioxymethamphetamine (MDMA) Effects on Psychological, Relational… Herzog Hospital Recruiting 2024-05-01
NCT04985344 Treatment of Pediatric Post-traumatic Stress Disorder With Memory Reactivation Under the… University Hospital, Toulouse Recruiting 2023-08-28
NCT04801589 Goal-Directed Sedation in Mechanically Ventilated Infants and Children Vanderbilt University Medical Center Active, Not Recruiting 2026-09-11
NCT07670702 An Evaluation of the Long-Term Safety and Efficacy of TSND-201 for the Treatment of PTSD Transcend Therapeutics Enrolling by Invitation 2026-09-04
NCT07792122 Women Who Are Victims of Violence: Treatment of PTSD Through Reactivation of Traumatic… University Hospital, Toulouse Not Yet Recruiting 2026-08-28
NCT06117306 MDMA-assisted Massed Prolonged Exposure for PTSD Healing Breakthrough Active, Not Recruiting 2026-08-26
NCT03539614 Predicting Responses to PTSD Treatment With Iris and Cardiovascular Tests VA Office of Research and Development Active, Not Recruiting 2026-08-14
See all 608 active PTSD trials with filters →

Top sponsors by active trials in this area

VA Office of Research and Development (63) · Medical University of South Carolina (12) · Karolinska Institutet (11) · The University of Texas Health Science Center at San Antonio (10) · Yale University (10) · Massachusetts General Hospital (9) · Emory University (8) · Stanford University (8) · Wayne State University (8) · The University of Texas Health Science Center, Houston (7)

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