RESYNC-BH is a research study testing a personalized, non-drug brain-and-body treatment program for adults with ongoing behavioral health symptoms such as depression, anxiety, trauma-related symptoms, sleep problems, attention difficulties, or substance-use concerns. Rather than treating participants only according to a psychiatric diagnosis, the study assigns them to one of several treatment approaches based on their symptoms, physiologic measures, and clinical presentation. Treatment may include noninvasive brain or nerve stimulation, light, sound, vibration, regulated breathing, and AIP-informed integrative psychotherapy.
The study has two main purposes. First, investigators want to determine whether these personalized treatment combinations can produce rapid and lasting improvements in symptoms, daily functioning, and maladaptive patterns such as avoidance, hypervigilance, rumination, craving, or emotional shutdown. Second, investigators want to identify objective changes in the brain and body that occur before, during, and after treatment. These measures include brain activity, heart rate and heart rate variability, other physiologic signals, cognitive measures, blood biomarkers, and standardized behavioral health questionnaires.
The study hypothesis is that meaningful behavioral health improvement is accompanied by measurable changes in brain, body, and behavioral signals, and that early changes in these signals can help predict which treatment approach is most appropriate for an individual, whether treatment is working, whether a person is becoming less stable, and whether improvement is likely to last. The long-term goal is to develop more objective and personalized ways to monitor behavioral health treatment response rather than relying only on symptoms reported at occasional clinic visits.