Sponsor pipeline

Eli Lilly and Company clinical trial pipeline

Get alerts when Eli Lilly and Company's trials change

229 active trials 115 recruiting 92 Phase 3 54 disease areas 63 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-16

What changed in the last 30 days showing 41 of 63 changes on 20 trials

2026-09-15
Trial terminated
Trial terminated: Sponsor Decision
Final enrollment: 77 participants (planned 144)
Primary completion confirmed: August 2026 (last estimated November 2026)
NCT07152002 A Study of LY4064912 in Healthy Participants and With Overweight or Obesity · Phase 1
2026-09-10
Trial terminated
Trial terminated: Original scientific question rendered moot by the external scientific community
Final enrollment: 1 participants — 2% of the 48 planned
Primary completion confirmed: April 2025 (last estimated August 2026)
NCT06916143 Comparing the Extent to Which Three Different Formulations of LY4100511 (DC-853) Are Made… · Phase 1
2026-09-15
Primary completion pushed: 2026-12 → 2027-05
Enrollment reduced: 240 → 200 participants
Completion pushed: 2027-01 → 2027-06
NCT06897475 A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a… · Phase 2
2026-09-05
Primary completion pushed: 2027-02 → 2029-06
Primary endpoint(s) modified
Enrollment increased: 495 → 575 participants
Interventions modified
Completion pushed: 2027-04 → 2029-06
Trial arms changed: 9 → 11
NCT06400472 A Study of Sofe-M in Participants With Selected Advanced Solid Tumors · Phase 1
2026-08-21
Primary endpoint(s) modified
Enrollment increased: 535 → 677 participants
Trial arms changed: 5 → 8
NCT05614739 FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With… · Phase 1
2026-09-15
Trial completed
Final enrollment: 712 participants (planned 600)
Primary completion confirmed: July 2026 (last estimated November 2026)
NCT06649045 A Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and… · Phase 3
2026-09-12
Trial completed
Primary completion confirmed: July 2026 (last estimated September 2026)
NCT05536804 A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic… · Phase 2
2026-08-22
Recruitment opened
Trial sites expanded: 37 → 40 locations
NCT07613307 A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes Who Observe… · Phase 3
2026-08-21
Trial completed
NCT06921759 A Study to Investigate the Efficacy and Safety of Lebrikizumab in Participants With… · Phase 3
2026-08-22
Enrollment closed, study ongoing
Primary completion moved earlier: 2027-10 → 2027-07
Completion moved earlier: 2027-10 → 2027-07
NCT07438444 A Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2… · Phase 4
2026-08-22
Trial completed
NCT06046729 A Study of Eltrekibart (LY3041658) in Adult Participants With Moderate to Severe… · Phase 2
2026-08-21
Recruitment opened
NCT07612267 A Study to Measure Mirikizumab Levels in Breast Milk of Lactating Participants Receiving… · Phase 4
2026-08-20
Recruitment opened
NCT07641504 A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic… · Phase 2
2026-08-20
Recruitment opened
NCT07641517 A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With… · Phase 2
2026-08-26
Trial completed
NCT07592572 A Study of the Effects of Itraconazole on LY4395089 in Healthy Participants · Phase 1
2026-08-25
Trial completed
NCT07232732 A Study of LY3549492 in Healthy Participants and Participants With Overweight or Obesity · Phase 1
2026-08-22
Recruitment opened
NCT07547540 A Study of LY3971297 in Participants With Heart Failure · Phase 1
2026-08-22
Trial completed
NCT07313813 A Study to Evaluate the Effect of Fasting Duration and Dulaglutide (LY2189265)… · Phase 1
2026-08-22
Trial completed
NCT05241834 A Study of LOXO-260 in Cancer Patients With a Change in a Particular Gene (RET) That Has… · Phase 1
2026-08-22
Enrollment closed, study ongoing
NCT07545590 A Study of Eltrekibart (LY3041658) in Healthy Participants · Phase 1

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-09-14 NCT07817875 Efficacy, Safety, and Pharmacokinetics of Tirzepatide (LY3298176) Once Weekly Versus… Phase 3 Not Yet Recruiting
2026-09-14 NCT07818967 A Study of Abemaciclib (LY2835219) in Healthy Participants Phase 1 Not Yet Recruiting
2026-09-11 NCT07814417 A Study of Olomorasib (LY3537982) in Participants With Advanced Colorectal Cancer and a… Phase 2 Not Yet Recruiting
2026-09-08 NCT07808060 A Study of Eloralintide (LY3841136) in Female Participants With Obesity or Overweight Phase 1 Not Yet Recruiting
2026-09-08 NCT07808073 A Study of LY4329090 in Participants With Obesity or Overweight Who Are Otherwise Healthy Phase 1 Not Yet Recruiting
2026-09-04 NCT07803744 A Study of Tirzepatide (LY3298176) in Participants With Type 1 Diabetes Mellitus and… Phase 1 Not Yet Recruiting
2026-09-03 NCT07801300 A Study of LY5625575 in Healthy Participants and in Participants With Inflammation… Phase 1 Not Yet Recruiting
2026-08-31 NCT07794579 A Study of Orforglipron in Participants With Overweight at Risk of Development of… Phase 3 Not Yet Recruiting
2026-08-31 NCT07794592 A Study Comparing Two Ways of Taking Olomorasib (LY3537982) in Healthy Participants Phase 1 Not Yet Recruiting
2026-08-27 NCT07790861 A Study of Orforglipron (LY3502970) in Chinese Participants With Obesity or Overweight… Phase 3 Not Yet Recruiting

Active trials by phase

Phase 1
71
Phase 1/2
5
Phase 2
45
Phase 2/3
1
Phase 3
91
Phase 4
10
Not charted: 6 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 229

NCT IDTitleConditionStatusUpdated
Phase 4
NCT07247084 A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants… Obesity Recruiting 2026-09-09
NCT06864026 A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in… Psoriatic Arthritis Recruiting 2026-09-08
NCT07612267 A Study to Measure Mirikizumab Levels in Breast Milk of Lactating Participants Receiving… Lactation Recruiting 2026-09-08
NCT06857942 A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation… Psoriasis Recruiting 2026-09-04
NCT07218341 A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic… Chronic Lymphocytic Leukemia Recruiting 2026-09-04
NCT06876649 A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib Chronic Lymphocytic Leukemia Recruiting 2026-03-02
NCT06876662 A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic… Chronic Lymphocytic Leukemia Recruiting 2026-03-02
NCT07438444 A Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2… Diabetes Mellitus, Type 2 Active, Not Recruiting 2026-08-21
NCT07006792 A Study to See How Well Lebrikizumab Works in Adults and Adolescents With Moderate Atopic… Atopic Dermatitis Active, Not Recruiting 2026-05-22
NCT05433584 A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants… Type 2 Diabetes Active, Not Recruiting 2025-12-12
Phase 3
NCT05723198 A Study of Baricitinib (LY3009104) in Children From 6 Years to Less Than 18 Years of Age… Areata Alopecia Recruiting 2026-09-08
NCT06119581 A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without… Carcinoma, Non-Small-Cell Lung Recruiting 2026-09-08
NCT06338995 A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal… Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Recruiting 2026-09-08
NCT06890598 Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With… Carcinoma, Non-Small-Cell Lung Recruiting 2026-09-08
NCT07153471 A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and… Osteoarthritis Recruiting 2026-09-08
NCT07165028 A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated… Metabolic Dysfunction-Associated Steatotic Liver Disease Recruiting 2026-09-08
NCT07174336 A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in… Breast Neoplasms Recruiting 2026-09-08
NCT07202884 A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have… Urinary Incontinence,Stress Recruiting 2026-09-08
NCT07213804 A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With… Ovarian Neoplasms Recruiting 2026-09-08
NCT07223593 Efficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease Peripheral Arterial Disease Recruiting 2026-09-08
NCT07241390 A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With… Atherosclerosis Cardiovascular Disease Recruiting 2026-09-08
NCT07282600 A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type… Overweight Recruiting 2026-09-08
NCT07353931 Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee… Osteoarthritis Recruiting 2026-09-08
NCT07369011 A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and… Sleep Apnea, Obstructive Recruiting 2026-09-08
NCT07392190 A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are… Overweight Recruiting 2026-09-08
See all 229 active Eli Lilly and Company trials with filters →

Disease areas by active trials, top 10 of 54

Obesity (50) · Diabetes (23) · Breast Cancer (22) · Alzheimer's Disease (16) · Lung Cancer (16) · Non-Small Cell Lung Cancer (NSCLC) (16) · Type 2 Diabetes (16) · Colorectal Cancer (8) · Ulcerative Colitis (8) · Crohn's Disease (7)

Get alerts when Eli Lilly and Company's trials change
Status changes, date slips, and new filings: detected daily, delivered to your inbox.
Start monitoring free