Prevention of Heart Failure in Type 2 Diabetes by Exercise Intervention

Global longitudinal strain emerged as an important predictive marker that could be assessed during echocardiography. It enabled the detection of subclinical myocardial systolic dysfunction, without observable reductions in cardiac output or left ventricular ejection fraction, often years before diabetes induced heart failure. In asymptomatic T2D patients with no history of cardiovascular disease, an impaired global longitudinal strain is a predictor of future adverse left ventricular remodeling and adverse cardiovascular events. Exercise training is a promising intervention to interfere in the diabetes induced heart failure pathophysiology. However, the impact of different exercise modalities (e.g. intensity and volume) on the global longitudinal strain in type 2 diabetes (T2D) is unknown.

NCT Number	NCT05023538
Lead Sponsor	Hasselt University Collaborators: Jessa Hospital, KU Leuven, University Ghent
Conditions	Type 2 Diabetes
Enrollment	182 participants
Start Date	2022-03-01
Primary Completion	2026-06-01 (estimated)
Study Completion	2026-12-01 (estimated)
Updated on ClinicalTrials.gov	2024-09-25