Clinical Trial

Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
This goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol. It will be determined if one works better and is more tolerable than the others. Research participants will: * Be randomly assigned to one of the three medications. * Provide information about their migraine pattern using a daily headache diary and during research visits.
Protocol Amendment History 2 changes
notable Trial sites expanded: 23 -> 35 locations 2026-05-23
notable Trial sites expanded: 18 -> 23 locations 2026-04-04
Trial Details
NCT Number NCT06972056
Lead Sponsor Mayo Clinic
Collaborators: University of Iowa, Patient-Centered Outcomes Research Institute, AbbVie
Conditions Migraine
Enrollment 1,335 participants
Start Date 2025-07-09
Primary Completion 2029-03-01 (estimated)
Study Completion 2029-12-01 (estimated)
Updated on ClinicalTrials.gov 2026-07-30