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Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

StatusRecruiting
PhasePhase 4
Started2025-07-09
View on ClinicalTrials.gov ↗

Amendment history

2026-07-29
Study Status, Contacts/Locations v13
Study sites35→36
2026-06-25
Study Status, Contacts/Locations v12
Study sitescontacts updated at 3 of 35 sites
2026-06-12
Study Status, Contacts/Locations v11
Study sites35 entries, revised
Keck School of Medicine of USC Keck
2026-05-20
Study Status, Contacts/Locations v10
Trial sites expanded: 23 → 35 locations
2026-04-01
Study Status, Contacts/Locations v9
Trial sites expanded: 18 → 23 locations
Show 8 earlier versions
2026-03-11
Study Status, Contacts/Locations v8
Study sites17→18
2026-01-29
Study Status, Contacts/Locations v7
Study sites9→17
2025-11-13
Study Status, Contacts/Locations v6
Study sites7→9
2025-08-06
Study Status, Contacts/Locations v5
Start dateestimated 2025-07→confirmed 2025-07-09
Study sitesdetails revised at 1 of 7 sites
2025-07-16
Study Status, Contacts/Locations v4
Study sites7 entries, revised
MayoApple ClinicMed Research
2025-07-09
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v3
Trial statusNot Yet Recruiting→Recruiting
Study sites5→7
2025-06-26
Study Status, Contacts/Locations v2
Study sitescontacts updated at 1 of 5 sites
2025-05-19
Study Status, Contacts/Locations v1
Re-verified, no change to tracked fields
2025-05-07
Original filing
Mayo Clinic
1,015 trials monitored
See 115 trials at risk
Migraine
463 trials monitored
See 25 trials at risk
This goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol. It will be determined if one works better and is more tolerable than the others. Research participants will: * Be randomly assigned to one of the three medications. * Provide information about their migraine pattern using a daily headache diary and during research visits.
Trial Details
NCT Number NCT06972056
Lead Sponsor Mayo Clinic
Collaborators: University of Iowa, Patient-Centered Outcomes Research Institute, AbbVie
Conditions Migraine
Enrollment 1,335 participants
Start Date 2025-07-09
Primary Completion 2029-03-01 (estimated)
Study Completion 2029-12-01 (estimated)
Updated on ClinicalTrials.gov 2026-09-16