ClinicalTrials.gov term: Migraine Disorders
41 trials changed in the last 30 days: 1 stopped, 19 with notable changes, 21 with minor changes only.
Trial terminated
Also in this update: Primary completion pushed from Jun 30, 2020 to Sep 28, 2026; Study completion date changed from estimate of Jun 30, 2026 to Sep 28, 2026
University of PennsylvaniaNot applicable NCT03081390 Registry history of NCT03081390 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Sep 5, 2026 to Mar 26, 2027
Also in this update: Trial sites reduced: 83 → 79 locations; Study completion pushed from Oct 31, 2026 to Mar 26, 2027
H. Lundbeck A/SPhase 3 NCT04965675 Registry history of NCT04965675 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from May 2026 to Jun 2027
Also in this update: Study completion pushed from Dec 2026 to Dec 2027
The Cleveland ClinicNot specified NCT06212661 Registry history of NCT06212661 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Dec 31, 2026 to Dec 31, 2028
Antonios LikourezosPhase 4 NCT06473597 Registry history of NCT06473597 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Nov 1, 2025 to Nov 1, 2027
Taichung Veterans General HospitalNot applicable NCT06584409 Registry history of NCT06584409 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Aug 2026 to Sep 3, 2028
Mayo ClinicNot applicable NCT05112289 Registry history of NCT05112289 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Jun 2026 to Jun 2028
Also in this update: Study completion pushed from Dec 2026 to Jan 2029
University of Colorado, DenverNot specified NCT06670053 Registry history of NCT06670053 on ClinicalTrials.gov (opens the registry)
Primary endpoint(s) modified
Also in this update: Recruitment opened
Daniel A Tonetti, MDPhase 2 NCT07361549 Registry history of NCT07361549 on ClinicalTrials.gov (opens the registry)
Primary endpoint(s) modified
Also in this update: Enrollment reduced: 1036 → 238 participants; Interventions modified
Beijing Tiantan HospitalNot applicable NCT07347028 Registry history of NCT07347028 on ClinicalTrials.gov (opens the registry)
Recruitment opened
Also in this update: Start date pushed from Sep 2026 to Oct 2026
Kallyope Inc.Phase 3 NCT07816367 Registry history of NCT07816367 on ClinicalTrials.gov (opens the registry)
Recruitment opened
Also in this update: Primary completion pushed from Sep 12, 2028 to Oct 21, 2028; Study completion pushed from Dec 11, 2028 to Jan 19, 2029; and 1 more change in the last 30 days
PfizerPhase 3 NCT07729462 Registry history of NCT07729462 on ClinicalTrials.gov (opens the registry)
Recruitment opened
Cortex NeurovascularNot specified NCT07652034 Registry history of NCT07652034 on ClinicalTrials.gov (opens the registry)
Recruitment opened
Columbia UniversityPhase 3 NCT07629635 Registry history of NCT07629635 on ClinicalTrials.gov (opens the registry)
Recruitment opened
University Hospital, Clermont-FerrandNot applicable NCT07067112 Registry history of NCT07067112 on ClinicalTrials.gov (opens the registry)
Enrolling by invitation only
Beni-Suef UniversityNot applicable NCT07762690 Registry history of NCT07762690 on ClinicalTrials.gov (opens the registry)
Recruitment opened
Mahidol UniversityNot applicable NCT07568496 Registry history of NCT07568496 on ClinicalTrials.gov (opens the registry)
Primary completion moved earlier from Nov 29, 2031 to Mar 27, 2029
PfizerPhase 3 NCT05156398 Registry history of NCT05156398 on ClinicalTrials.gov (opens the registry)
Start date pushed from Sep 1, 2026 to Nov 1, 2026
National and Kapodistrian University of AthensNot specified NCT07847554 Registry history of NCT07847554 on ClinicalTrials.gov (opens the registry)
Start date pushed from Sep 1, 2026 to Nov 1, 2026
National and Kapodistrian University of AthensNot specified NCT07843745 Registry history of NCT07843745 on ClinicalTrials.gov (opens the registry)
Start date pushed from Sep 1, 2026 to Nov 1, 2026
National and Kapodistrian University of AthensNot specified NCT07847528 Registry history of NCT07847528 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Merz Therapeutics GmbHPhase 3 NCT07018700 Registry history of NCT07018700 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Also in this update: Study completion moved earlier from Mar 2028 to Sep 2027; Primary completion moved earlier from Oct 2027 to Mar 2027
Merz Therapeutics GmbHPhase 3 NCT07018713 Registry history of NCT07018713 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Primary completion date changed from estimate of Dec 31, 2026 to Sep 15, 2026; Final enrollment: 160 participants (planned 200)
Norwegian University of Science and TechnologyNot specified NCT06893874 Registry history of NCT06893874 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Study completion date changed from estimate of Jun 30, 2026 to May 6, 2026
Children's Hospital Medical Center, CincinnatiPhase 2 NCT04567355 Registry history of NCT04567355 on ClinicalTrials.gov (opens the registry)
Primary and study completion pushed from Jul 31, 2026 to Oct 31, 2026
PfizerNot specified NCT06898047 Registry history of NCT06898047 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Final enrollment: 228 participants (planned 159)
Bozok UniversityNot specified NCT07554664 Registry history of NCT07554664 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Also in this update: Study completion pushed from Jul 2026 to Dec 2026
Fundación de Investigación Biomédica - Hospital Universitario de La PrincesaNot specified NCT06459648 Registry history of NCT06459648 on ClinicalTrials.gov (opens the registry)
Trial completed
Also in this update: Primary completion date changed from estimate of Dec 31, 2026 to Jul 15, 2026; Final enrollment: 6 participants (planned 30)
Medical University InnsbruckNot applicable NCT07419607 Registry history of NCT07419607 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Also in this update: Primary and study completion pushed from Jul 2026 to Dec 2026
Fundación de Investigación Biomédica - Hospital Universitario de La PrincesaNot specified NCT06459635 Registry history of NCT06459635 on ClinicalTrials.gov (opens the registry)
Enrollment closed, study ongoing
Children's Hospital Medical Center, CincinnatiNot applicable NCT04715685 Registry history of NCT04715685 on ClinicalTrials.gov (opens the registry)
Trial sites reduced: 70 → 64 locations
H. Lundbeck A/SPhase 3 NCT05164172 Registry history of NCT05164172 on ClinicalTrials.gov (opens the registry)
Trial sites reduced: 119 → 11 locations
AmgenPhase 3 NCT03836040 Registry history of NCT03836040 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 21 → 24 locations
And 1 more change in the last 30 days
PfizerPhase 4 NCT07609914 Registry history of NCT07609914 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Mar 2028 to Sep 2028
Also in this update: Study completion pushed from Mar 2028 to Nov 2028
George Washington UniversityPhase 1/2 NCT06792500 Registry history of NCT06792500 on ClinicalTrials.gov (opens the registry)
Primary completion pushed from Jun 17, 2026 to Oct 17, 2026
Also in this update: Study completion pushed from Jun 30, 2026 to Nov 30, 2026
Bozok UniversityNot specified NCT07567300 Registry history of NCT07567300 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 6 → 20 locations
Aspeya, Inc.Phase 2 NCT07646613 Registry history of NCT07646613 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 26 → 35 locations
Evommune, Inc.Phase 2 NCT07616128 Registry history of NCT07616128 on ClinicalTrials.gov (opens the registry)
Trial sites expanded: 2 → 6 locations
PfizerPhase 4 NCT07685769 Registry history of NCT07685769 on ClinicalTrials.gov (opens the registry)
Enrollment increased: 356 → 450 participants
NYU Langone HealthNot applicable NCT06077838 Registry history of NCT06077838 on ClinicalTrials.gov (opens the registry)
Interventions modified
Kallyope Inc.Phase 3 NCT07674654 Registry history of NCT07674654 on ClinicalTrials.gov (opens the registry)
Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Recruiting
IRCCS National Neurological Institute "C. Mondino" FoundationNot specified NCT06549270 Registry history of NCT06549270 on ClinicalTrials.gov (opens the registry)
Changed
| First posted | Trial | Sponsor | Phase |
|---|---|---|---|
| 2026-10-13 | NCT07871097 Acute Treatment of Vestibular Migraine by Rimegepant | Wensheng Qu new | Phase 4 |
| 2026-10-06 | NCT07861412 A Prospective Interventional Study of Intranasal Zavegepant for the Acute Treatment of… | American Center for Psychiatry and Neurology new | |
| 2026-10-02 | NCT07856056 Nortriptyline Compared With Amitriptyline for Migraine Prevention at SQUH | Sultan Qaboos University new | Phase 4 |
| 2026-09-17 | NCT07824661 Impact of Cessation of Toothpaste in Patients With Migraine Headaches | St.John's National Academy of Health Sciences new | |
| 2026-09-17 | NCT07826910 Effect of Atogepant on the Vestibulo-Ocular Reflex in Healthy Adults and Adults With… | Konrad Peter Weber new | Phase 4 |
| 2026-09-16 | NCT07822386 Migraine Characteristics and Associated Factors | Lokman Hekim University new | |
| 2026-09-03 | NCT07802912 Efficacy of Traditional Integrated Islamic Psychotherapy and Cognitive Behavioural… | GIFT University new | |
| 2026-08-28 | NCT07792681 Efficacy and Safety of BR005-036C Tablets for the Acute Treatment of Migraine in Adults | Brise Pharmaceuticals Co., Ltd. new | Phase 2/3 |
| 2026-08-21 | NCT07779486 High- vs Standard-Dose Intravenous Magnesium for Acute Headache | University of Monastir new | |
| 2026-08-19 | NCT07774286 Multi-Segmental Spinal Manual Therapy in Women With Episodic Migraine | Borna Farhoomand new |
| Early Phase 1 | 4 | |
| Phase 1 | 4 | |
| Phase 1/2 | 2 | |
| Phase 2 | 20 | |
| Phase 2/3 | 1 | |
| Phase 3 | 41 | |
| Phase 4 | 28 |
AbbVie (13) · Pfizer (13) · Second Affiliated Hospital, Zhejiang University, School of Medicine (8) · Mayo Clinic (7) · University Hospital, Clermont-Ferrand (7) · Assiut University (6) · Danish Headache Center (6) · University of Florence (5) · Beijing Tiantan Hospital (4) · Beni-Suef University (4)