Disease landscape

Migraine clinical trials

Get alerts when Migraine trials change

326 active trials 170 recruiting 38 Phase 3 192 sponsors 57 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 36 of 57 changes on 20 trials

2026-08-21
Primary completion pushed: 2027-08-01 → 2028-08-01
Recruitment opened
NCT07221292 Pivotal Study of N-acetyl-L-leucine for CACNA1A · IntraBio Inc · Phase 3
2026-08-15
Primary completion pushed: 2027-06 → 2027-11
Completion pushed: 2027-09 → 2027-11
NCT06417775 Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult… · AbbVie · Phase 3
2026-09-02
Primary completion pushed: 2026-06 → 2026-10-31
Completion pushed: 2026-06 → 2026-12-31
NCT06938178 High-Density EEG-MEG-wearable EEG: Comparison of Quantitative Electroencephalographic… · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
2026-08-14
Primary completion pushed: 2026-07-31 → 2027-07-31
Completion pushed: 2026-07-31 → 2027-07-31
NCT05669703 NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood… · National Institute of Mental Health (NIMH)
2026-08-12
Primary completion pushed: 2026-04 → 2028-04
Completion pushed: 2026-04 → 2028-04
NCT06085144 Emgality for Migraine in Breastmilk · University of California, San Francisco
2026-08-12
Primary completion pushed: 2026-06 → 2027-06
Trial status changed: Enrolling by Invitation → Active, Not Recruiting
Completion pushed: 2026-06 → 2027-06
NCT05755945 A Study of Wearable Devices to Predict Migraines · Mayo Clinic
2026-08-14
Primary endpoint(s) modified
Phase changed: not specified → not applicable
Sponsor changed: [Redacted] → Salvia BioElectronics
Trial status changed: Withheld → Recruiting
Enrollment changed: None → 150
Trial arms changed: 0 → 2
NCT07719608 A Pivotal Clinical Study to Evaluate the MySalvia System for the Treatment of Resistant… · Salvia BioElectronics
2026-08-25
Primary endpoint(s) modified
NCT07774286 Multi-Segmental Spinal Manual Therapy in Women With Episodic Migraine · Borna Farhoomand
2026-08-27
Enrollment reduced: 72 → 15 participants
Trial completed
Primary completion moved earlier: 2026-07 → 2026-05-05
NCT06173661 Fremanezumab Treatment of Migraine in Women With Menstrual Migraine Ages 18-45 · Brigham and Women's Hospital · Phase 4
2026-09-05
Trial completed
NCT07594769 A Study to Compare the Blood Levels of Two Dosage Formulations of the Study Medicine in… · Pfizer · Phase 1
2026-08-07
Recruitment opened
NCT07674654 A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine · Kallyope Inc. · Phase 3
2026-09-03
Primary completion pushed: 2026-12 → 2027-03
Completion pushed: 2026-12 → 2027-03
NCT07646613 Study Evaluating the Efficacy, Safety, and Tolerability of ASY202 (Dihydroergotamine… · Aspeya, Inc. · Phase 2
2026-08-22
Recruitment opened
NCT07685769 A Study to Find Out if the Medicine Called Rimegepant is Safe for Adults in India · Pfizer · Phase 4
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT05484349 TIzanidine for the Preventive Treatment of Episodic MigrainE （TIME） · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 3
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT04151472 Idebenone for the Preventive Treatment of Migraine · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 3
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT06992674 The R-E-V-I-V-A-L Study · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 2
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT06748664 A Clinical Trial of Rimegepant for Vestibular Migraine Evaluation: Pre-experiment · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 2
2026-09-03
Trial completed
Primary completion confirmed: March 2026 (last estimated October 2025)
NCT07029126 Improving the Perception of Stress and Mutuality in Caregivers (MI-DEAR Study) of… · Fondazione Policlinico Universitario Campus Bio-Medico
2026-09-04
Results posted: 2026-09-03
NCT05810038 A Study to Learn About the Safety and Effects of Rimegepant to Prevent Migraine in… · Pfizer · Phase 3
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07451158 Multicenter, Double-blind, and Randomized Controlled Trial of Ultra-Distal TENS Device… · Second Affiliated Hospital, School of Medicine, Zhejiang University

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-03 NCT07802912 Efficacy of Traditional Integrated Islamic Psychotherapy and Cognitive Behavioural… GIFT University new
2026-08-28 NCT07792681 Efficacy and Safety of BR005-036C Tablets for the Acute Treatment of Migraine in Adults Brise Pharmaceuticals Co., Ltd. new Phase 2/3
2026-08-21 NCT07779486 High- vs Standard-Dose Intravenous Magnesium for Acute Headache University of Monastir new
2026-08-19 NCT07774286 Multi-Segmental Spinal Manual Therapy in Women With Episodic Migraine Borna Farhoomand new
2026-08-10 NCT07754266 Headache Ear Auditory Dizziness Sinus (HEADS) Registry Association of Migraine Disorders new
2026-08-07 NCT07751497 A Randomized, Open-Label, Multi-Center Study of Vestibular Migraine Prevention… Second Affiliated Hospital, Zhejiang University, School of Medicine new Phase 2
2026-08-04 NCT07743814 EFFECT OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION (tDCS) OF PRIMARY MOTOR CORTEX… Dr. Ram Manohar Lohia Hospital new Phase 3
2026-08-03 NCT07743255 Preventive Role of Melatonin and Propranolol Administration in Pediatric Migraine Nishtar Medical University new
2026-07-22 NCT07720895 Default Mode Network Connectivity and Nocebo Responses in Migraine: A Functional MRI Study Ioanna Spanou new
2026-07-13 NCT07698249 Headache Diary for Migraine Patients Hackensack Meridian Health new

Active trials by phase

Early Phase 1
5
Phase 1
4
Phase 1/2
1
Phase 2
21
Phase 2/3
1
Phase 3
37
Phase 4
24
Not charted: 233 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 326

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07609914 A Study to Learn About the Safety of Taking an Additional Dose of the Medicine Rimegepant… Pfizer Recruiting 2026-08-24
NCT07685769 A Study to Find Out if the Medicine Called Rimegepant is Safe for Adults in India Pfizer Recruiting 2026-08-21
NCT06972056 Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study Mayo Clinic Recruiting 2026-07-30
NCT07301008 Rimegepant as Preemptive Treatment for Predictable Trigger-Induced Migraine in Adult… Medstar Health Research Institute Recruiting 2025-12-24
NCT06473597 A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache Antonios Likourezos Recruiting 2025-10-01
NCT06401642 Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those… Mayo Clinic Recruiting 2025-09-09
NCT07093138 Evaluation of Efficacy and Safety of Topical Cannabidiol (Canvert-M Produced by Alasht… Alasht Pharmed Recruiting 2025-07-30
NCT07022496 Assessment of Oral Caffeine Intake in Changing the Severity of Acute Migraine Attack… Ain Shams University Recruiting 2025-06-15
NCT04748601 Qudexy XR for the Prevention of Migraine in Children 6 to 11 Years Old Upsher-Smith Laboratories Recruiting 2025-01-27
NCT04925414 Migraine and High Flow Oxygenotherapy at the Emergency Department (MiOx) Centre Hospitalier Universitaire de Nice Recruiting 2024-11-18
NCT06509503 Impact of Combined Oral Contraceptive Pills on Migraine Kafrelsheikh University Recruiting 2024-10-09
NCT07780136 Comparison of the Effectiveness of Greater Occipital Nerve and Supratrochlear Nerve… Assiut University Not Yet Recruiting 2026-08-21
NCT07763678 Efficacy of Ultrasound-Guided Combined Greater Occipital Nerve Block and Greater… Assiut University Not Yet Recruiting 2026-08-13
NCT07655700 Comparison of Propranolol, Flunarizine and Their Combination in Preventing Migraine in… Chittagong Medical College Not Yet Recruiting 2026-06-22
NCT07655440 Comparing Migraine Preventive Therapies vs. Anti-CGRP Therapies for Tinnitus in Patients… Stanford University Not Yet Recruiting 2026-06-17
NCT06701526 A Trial of Eptinezumab in Participants With Migraine and Insufficient Response to… H. Lundbeck A/S Active, Not Recruiting 2026-05-13
NCT07100496 Evaluation of MIG-SPRAY Treatment on Migraine University Hospital, Clermont-Ferrand Active, Not Recruiting 2026-03-18
NCT07336056 Nerivio Efficacy Under High-Frequency Use Theranica Active, Not Recruiting 2026-01-13
NCT02670161 Quality Improvement and Practice Based Research in Neurology Using the EMR Endeavor Health Enrolling by Invitation 2025-08-24
NCT06786650 Comparision of the Analgesic Effects of Intravenous Ibuprofen and Tenoxicam in Acute… Haydarpasa Numune Training and Research Hospital Active, Not Recruiting 2025-06-26
NCT05503082 Ubrogepant treatmeNt in mIgraine Patients Utilizing mOnoclonal aNtibodies Chicago Headache Center & Research Institute Active, Not Recruiting 2024-08-20
NCT05724771 COACT Study: CGRPmAbs + OnabotulinumtoxinA Assessment of Chronic Migraine Treatments Study Chicago Headache Center & Research Institute Active, Not Recruiting 2024-08-20
NCT06499116 Comparison of the Effectiveness of First-line Preventive Treatment of Migraine in Primary… Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina Not Yet Recruiting 2024-07-12
NCT06432127 Role of Ultrasound Guide Greater Occipital Nerve Block at Second Cervical Vertebra in… Mahidol University Not Yet Recruiting 2024-05-29
Phase 3
NCT07221292 Pivotal Study of N-acetyl-L-leucine for CACNA1A IntraBio Inc Recruiting 2026-09-04
See all 326 active Migraine trials with filters →

Top sponsors by active trials in this area

AbbVie (14) · Pfizer (13) · Mayo Clinic (7) · Second Affiliated Hospital, School of Medicine, Zhejiang University (7) · University Hospital, Clermont-Ferrand (7) · Danish Headache Center (6) · Children's Hospital Medical Center, Cincinnati (5) · University of Florence (5) · Assiut University (4) · Beijing Tiantan Hospital (4)

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