Disease landscape

Sarcoma clinical trials

Get alerts when Sarcoma trials change

837 active trials 490 recruiting 43 Phase 3 338 sponsors 122 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 45 of 122 changes on 20 trials

2026-09-05
Recruitment suspended
Recruitment suspended: Protocol amendment
NCT06968988 Zanzalintinib in Combination With Ipilimumab and Nivolumab in Patients With Metastatic… · Washington University School of Medicine · Phase 1
2026-09-04
Trial terminated
Trial terminated: Polaris decided to close to accrual.
NCT05813327 Neoadjuvant ADI-PEG 20 + Ifosfamide + Radiotherapy in Soft Tissue Sarcoma · Washington University School of Medicine · Phase 1
2026-08-15
Recruitment suspended
Recruitment suspended: Other - Extend the observation period for current patients
NCT05691478 A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With… · National Cancer Institute (NCI) · Phase 2/3
2026-09-03
Primary completion pushed: 2026-06-30 → 2026-09-30
NCT04890067 Observational Study in Localized Osteosarcoma · Italian Sarcoma Group
2026-09-04
Primary completion pushed: 2026-08 → 2027-08
Completion pushed: 2026-08 → 2027-08
NCT05515575 A Study of Niraparib in People With Soft Tissue Sarcoma Who Have Changes in Their Tumor… · Memorial Sloan Kettering Cancer Center · Phase 2
2026-09-03
Primary completion pushed: 2027-07-30 → 2028-07-30
Completion pushed: 2028-07-30 → 2029-07-30
NCT05918640 Lurbinectedin in FET-Fused Tumors · Children's Hospital of Philadelphia · Phase 1/2
2026-08-15
Primary completion pushed: 2026-03 → 2027-10
Completion pushed: 2026-08 → 2027-12
NCT06537596 89Zr-olaratumab Dosimetry in Participants With PDGFR Alpha Positive Solid Tumours and… · Telix Pharmaceuticals (Innovations) Pty Ltd · Phase 1
2026-09-04
Primary completion pushed: 2026-08-14 → 2027-08-14
Completion pushed: 2026-08-14 → 2027-08-14
NCT00411060 Clinical Orthopaedic Data Bank (Acute and Chronic) · University of Florida
2026-09-03
Primary completion pushed: 2026-07-24 → 2027-07-24
Completion pushed: 2026-07-24 → 2027-07-24
NCT05837767 A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue · Memorial Sloan Kettering Cancer Center
2026-08-28
Primary completion pushed: 2026-07 → 2026-12
Completion pushed: 2027-07 → 2028-07
NCT05099666 Lurbinectedin + Doxorubicin In Leiomyosarcoma · Massachusetts General Hospital · Phase 1/2
2026-09-03
Primary endpoint(s) modified
Trial completed
Primary completion confirmed: June 2026 (last estimated June 2027)
NCT05864144 A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in… · Sensei Biotherapeutics, Inc. · Phase 1/2
2026-08-27
Primary completion pushed: 2026-08-28 → 2027-08-01
Recruitment opened
Completion pushed: 2027-02-01 → 2027-12-31
NCT07662239 Bridging Adolescent and Young Adult Sarcoma Survivors With Personalized Oncology Exercise… · Dana-Farber Cancer Institute
2026-08-18
Primary completion pushed: 2028-09-01 → 2030-09-01
Primary endpoint(s) modified
Enrollment increased: 45 → 105 participants
Completion pushed: 2030-09-01 → 2032-09-01
Trial arms changed: 2 → 4
NCT07139990 Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM) · University of Texas Southwestern Medical Center · Phase 1
2026-08-14
Primary completion pushed: 2035-12 → 2041-12
Primary endpoint(s) modified
Completion pushed: 2038-12 → 2044-12
NCT07172958 Selective Antigen Specific T Cells and CAR T Cells in Subjects With Relapsed/Refractory… · Children's National Research Institute · Phase 1
2026-08-07
Primary completion pushed: 2026-08-01 → 2027-08-01
Completion pushed: 2041-07-03 → 2042-07-03
NCT04715191 Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in… · Baylor College of Medicine · Phase 1
2026-08-29
Primary endpoint(s) modified
Enrollment increased: 30 → 48 participants
NCT07156565 Actinium Therapy for Late-stage Aggressive Sarcomas · Ratio Therapeutics, Inc. · Phase 1
2026-08-22
Primary completion pushed: 2025-12 → 2026-12
Trial status changed: Unknown → Recruiting
Completion pushed: 2026-06 → 2026-12
NCT04461171 Enhanced Recovery After Surgery in Extremity Sarcoma · Joshua Lawrenz
2026-08-11
Primary completion pushed: 2028-06-30 → 2030-06-30
Completion pushed: 2029-06-30 → 2035-06-30
NCT03959800 Molecular Basis of Pediatric Liver Cancer · University of Pittsburgh
2026-09-02
Primary endpoint(s) modified
NCT07428993 Evaluating Efficacy of B7-H3-CAR T Cells Administered at the End of Upfront Map… · St. Jude Children's Research Hospital · Phase 2
2026-09-01
Primary endpoint(s) modified
Interventions modified
NCT07695311 EWSR1 Immunotherapy in Ewing Sarcoma and DSRCT · Rabi Hanna · Phase 1

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-03 NCT07801222 A Study to Assess Safety and Efficacy of SOT106 in Patients With LRRC15-positive Advanced… SOTIO Biotech a.s. new Phase 1/2
2026-08-25 NCT07785882 Sarcoma and Intra-infusion Exercise for Better Outcomes Kira Bloomquist new
2026-08-19 NCT07774533 68Ga-B7-H3 Nanobody ImmunoPET in Osteosarcoma Peking University First Hospital new Early Phase 1
2026-07-29 NCT07734805 Radiological Diagnosis of Pediatric Neck Swellings Sohag University new
2026-07-29 NCT07734116 A Study of ONO-4538HSC in Pediatric Patients With Malignant Solid Tumors and in Patients… Ono Pharmaceutical Co., Ltd. new Phase 1/2
2026-07-27 NCT07729059 "Exercise Intervention to Increase Physical Activity in Young Sarcoma Survivors (Sport… Universität Duisburg-Essen new
2026-07-20 NCT07713732 TLN-499 in Combination With Venetoclax in Patients With Relapsed/Refractory Solid Tumors Treeline Biosciences, Inc. new Phase 1
2026-07-15 NCT07705334 A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic… SHY Therapeutics new Phase 1
2026-07-10 NCT07695311 EWSR1 Immunotherapy in Ewing Sarcoma and DSRCT Rabi Hanna new Phase 1
2026-07-10 NCT07696169 Disease Evolution and Risk Factors of AIDS-related Prevalent Cancers Shenzhen Third People's Hospital new

Active trials by phase

Early Phase 1
21
Phase 1
157
Phase 1/2
92
Phase 2
257
Phase 2/3
5
Phase 3
38
Phase 4
7
Not charted: 260 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 837

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06506838 Anlotinib Combined With Doxorubicin and Radiotherapy as Neoadjuvant Treatment for Soft… Guangdong Provincial People's Hospital Recruiting 2024-08-12
NCT06236022 The Effects of Sirolimus in Patients With Dilated Cardiomyopathy Infected With Kaposi… Tongji Hospital Recruiting 2024-02-01
NCT07802847 Innovative and Cooperative Pathway Integrating Oncogeriatric, Pharmaceutical and… Gustave Roussy, Cancer Campus, Grand Paris Not Yet Recruiting 2026-09-03
NCT03144206 Hyperbaric Oxygen Therapy for Soft Tissue Sarcoma Pilot Study Duke University Active, Not Recruiting 2026-03-27
NCT04033081 Registry of Sarcoma Patients Treated With Permanently Implantable LDR CivaSheet® CivaTech Oncology Active, Not Recruiting 2026-03-23
NCT03244020 LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic Oncology Massachusetts General Hospital Enrolling by Invitation 2025-10-03
NCT05844813 Neoadjuvant Chemotherapy Combined With Targeted Treatment in High-risk Retroperitoneal… Peking University International Hospital Enrolling by Invitation 2023-05-12
Phase 3
NCT06422806 Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for… National Cancer Institute (NCI) Recruiting 2026-09-03
NCT04307277 Interest of Peri Operative CHemotherapy In Patients With CINSARC High-risk Localized Soft… Institut Claudius Regaud Recruiting 2026-09-01
NCT05235165 Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With… Children's Oncology Group Recruiting 2026-08-25
NCT05304585 Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low… Children's Oncology Group Recruiting 2026-08-25
NCT07466316 A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose… Children's Oncology Group Recruiting 2026-08-25
NCT06263231 A Study to Investigate Efficacy & Safety of Intratumoral INT230-6 Compared to US Standard… Intensity Therapeutics, Inc. Recruiting 2026-08-11
NCT05646316 Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb… NRG Oncology Recruiting 2026-08-07
NCT06580314 Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian… NRG Oncology Recruiting 2026-08-07
NCT04031677 Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma European Organisation for Research and Treatment of Cancer - EORTC Recruiting 2026-05-22
NCT03016819 Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma… Advenchen Laboratories, LLC Recruiting 2026-02-25
NCT07174427 Multi-center Study of TBI-1301 (INN: Mipetresgene Autoleucel; Mip-cel) in Patients With… Takara Bio Inc. Recruiting 2026-02-18
NCT06127407 Ivosidenib in Participants With Locally Advanced or Metastatic Conventional… Servier Bio-Innovation LLC Recruiting 2026-02-06
NCT03422198 Short Course Vaginal Cuff Brachytherapy in Treating Participants With Stage I-II… University of Utah Recruiting 2025-12-12
NCT03805022 Benefit of Intensified Peri-operative Chemotherapy Within High-risk CINSARC Patients With… Institut Bergonié Recruiting 2025-10-02
NCT06332274 tislelizUMaB in canceR Patients With molEcuLar residuaL Disease Gustave Roussy, Cancer Campus, Grand Paris Recruiting 2025-05-13
NCT05597917 tTF-NGR Randomized Study - STS Universität Münster Recruiting 2025-04-04
NCT06836492 A Prospective Clinical Cohort Study on Stratified Treatment of Rhabdomyosarcoma Based on… Yizhuo Zhang Recruiting 2025-02-20
NCT06669013 Chemo-immunotherapy in Patients Under 18 Years of Age With Bone and Soft Tissue Sarcomas N.N. Petrov National Medical Research Center of Oncology Recruiting 2024-11-01
See all 837 active Sarcoma trials with filters →

Top sponsors by active trials in this area

National Cancer Institute (NCI) (67) · M.D. Anderson Cancer Center (45) · Memorial Sloan Kettering Cancer Center (36) · Mayo Clinic (19) · St. Jude Children's Research Hospital (13) · City of Hope Medical Center (12) · Sun Yat-sen University (11) · University Health Network, Toronto (11) · Baylor College of Medicine (10) · Children's Oncology Group (10)

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