Sponsor Pipeline

Children's Oncology Group Clinical Trial Pipeline

Data updated daily from ClinicalTrials.gov — last refresh 2026-08-16
70
Active Trials
30
Recruiting
26
Phase 3
10
Disease Areas
15
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-08-13 NCT06894979
Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly…
Enrollment closed, study ongoing
2026-08-07 NCT04089358
Mobile Health and Social Media Physical Activity Intervention Among Adolescent and Young…
date change Completion pushed: 2026-06-30 -> 2027-06-30
2026-07-31 NCT04195399
A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed…
date change Completion pushed: 2027-04-10 -> 2032-12-31
2026-07-31 NCT05705531
A Study About How Blood Cell Growth Patterns Relate to Heart Health After Treatment for…
Trial sites expanded: 32 -> 36 locations
2026-07-31 NCT07466316
A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose…
Recruitment opened
2026-07-31 NCT07466316
A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose…
Trial sites expanded: 0 -> 65 locations
2026-07-31 NCT05457556
Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for…
Enrollment reduced: 435 -> 66 participants
2026-07-31 NCT05457556
Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for…
date change Completion pushed: 2026-06-30 -> 2027-07-07
2026-07-31 NCT02981628
Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or…
Enrollment closed, study ongoing
2026-07-30 NCT06820957
Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing…
Enrollment reduced: 437 -> 2 participants
2026-07-30 NCT06820957
Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing…
date change Primary completion moved earlier: 2027-12-31 -> 2026-06-30
2026-07-30 NCT06820957
Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing…
date change Completion moved earlier: 2027-12-31 -> 2027-07-01
2026-07-30 NCT04994132
A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With…
date change Completion pushed: 2026-06-30 -> 2027-07-01
2026-07-25 NCT03223753
Web-Based Physical Activity Intervention in Improving Long Term Health in Children and…
Trial completed
2026-07-19 NCT06513962
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With…
Trial sites expanded: 193 -> 205 locations
Active Trials by Phase
Phase 3
24
Phase 2/3
2
Phase 2
15
Phase 1/2
4
Phase 1
5
Not specified
20
Active Trials — top 25 of 70
NCT IDTitleConditionStatus
Phase 3
NCT03126916 Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With… Ganglioneuroblastoma Recruiting
NCT05235165 Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With… Metastatic Malignant Neoplasm in the Lung Recruiting
NCT05304585 Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low… Embryonal Rhabdomyosarcoma Recruiting
NCT05711667 A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell… Hematopoietic and Lymphoid Cell Neoplasm Recruiting
NCT06401330 A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology… Stage I Mixed Cell Type Kidney Wilms Tumor Recruiting
NCT06647953 Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary… Pleuropulmonary Blastoma Recruiting
NCT03067181 Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric… Childhood Extracranial Germ Cell Tumor Recruiting
NCT03959085 Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk… B Acute Lymphoblastic Leukemia Recruiting
NCT05382338 A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss Childhood Medulloblastoma Recruiting
NCT07022678 Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With… Acute Myeloid Leukemia Recruiting
NCT06513962 Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With… Hematopoietic and Lymphatic System Neoplasm Recruiting
NCT04293562 A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for… Acute Myeloid Leukemia Recruiting
NCT07466316 A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose… Rhabdomyosarcoma Recruiting
NCT02521493 Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or… Acute Myeloid Leukemia Active, Not Recruiting
NCT03057054 Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children… Acute Graft Versus Host Disease Active, Not Recruiting
NCT02339740 Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic… Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2); PML-RARA Active, Not Recruiting
NCT03007147 Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed… Acute Lymphoblastic Leukemia Active, Not Recruiting
NCT02176967 Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With… Ganglioneuroblastoma Active, Not Recruiting
NCT05602194 Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for… B Acute Lymphoblastic Leukemia Active, Not Recruiting
NCT04939597 A Study to See if Memantine Protects the Brain During Radiation Therapy Treatment for a… Central Nervous System Carcinoma Active, Not Recruiting
NCT03533582 Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With… Childhood Hepatocellular Carcinoma Active, Not Recruiting
NCT04994132 A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With… Alveolar Rhabdomyosarcoma Active, Not Recruiting
NCT05457556 Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for… Acute Lymphoblastic Leukemia Active, Not Recruiting
NCT04089358 Mobile Health and Social Media Physical Activity Intervention Among Adolescent and Young… Hematopoietic and Lymphoid Cell Neoplasm Active, Not Recruiting
Phase 2/3
NCT06820957 Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing… CIC-Rearranged Sarcoma Active, Not Recruiting
See all 70 active Children's Oncology Group trials with filters →
Disease Areas
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