Clinical Trial

Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

Study acronym: STRASS2
Recruiting Phase 3
View on ClinicalTrials.gov →
Summary
This is a multicenter, randomized, open label phase lll trial to assess whether preoperative chemotherapy, as an adjunct to curative-intent surgery, improves the prognosis of high risk DDLPS (dedifferentiated Liposarcoma) and LMS (Leiomyosarcoma) patients as measured by disease free survival. After confirmation of eligibility criteria, patients will be randomized to either the standard arm or experimental arm.
Protocol Amendment History 1 change
notable Trial sites expanded: 164 -> 169 locations 2026-05-23
Trial Details
NCT Number NCT04031677
Lead Sponsor European Organisation for Research and Treatment of Cancer - EORTC
Collaborators: Canadian Cancer Trials Group, ECOG-ACRIN Cancer Research Group, Anticancer Fund, Belgium, Australia and New Zealand Sarcoma Association, Japan Clinical Oncology Group
Conditions Retroperitoneal Sarcoma, Liposarcoma, Leiomyosarcoma
Enrollment 250 participants
Start Date 2021-01-20
Primary Completion 2027-04-21 (estimated)
Study Completion 2028-04-21 (estimated)
Updated on ClinicalTrials.gov 2026-05-22