HIV Self-testing for Partners of HIV-uninfected Postpartum Women

The purpose of this study is to test the feasibility and acceptability of a combination intervention to promote HIV self-testing (HIVST) for Partners and PrEP uptake for HIV-uninfected Postpartum Women ("H4P"). H4P includes evidence-based cognitive behavioral therapy (CBT) strategies, such as communication skills training, motivational interviewing, and problem-solving. The investigators will conduct a randomized pilot trial of the H4P intervention to evaluate the feasibility, acceptability, and preliminary effectiveness of a multi-step PrEP uptake and HIV self-test kit intervention for postpartum HIV-uninfected women (N = 60 and their male partners) who report a partner of unknown serostatus, and their partners, in the province of KwaZulu-Natal, South Africa.

NCT Number	NCT07194902
Lead Sponsor	Massachusetts General Hospital Collaborators: National Institute of Mental Health (NIMH)
Conditions	HIV Self-testing, Male Partners of HIV-negative Postpartum Women, PrEP Uptake, Feasibility, Acceptability, HIV Prevention
Enrollment	120 participants
Start Date	2026-03-19
Primary Completion	2026-08-28 (estimated)
Study Completion	2026-08-28 (estimated)
Updated on ClinicalTrials.gov	2026-03-23