Disease landscape

Anxiety clinical trials

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1,540 active trials 759 recruiting 26 Phase 3 896 sponsors 229 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 50 of 229 changes on 20 trials

2026-09-04
Trial status changed: Not Yet Recruiting → Terminated
Trial terminated: minimum subject accrual complete
Primary completion confirmed: December 2019 (last estimated March 2027)
NCT02998502 The Use of a FDA Cleared, Drug-free, Breathing System for Anxiety and Panic Disorders in… · Johns Hopkins University
2026-09-03
Withdrawn before enrolling
Trial withdrawn: The collaborator could not proceed with the study due to personnel changes.
NCT07058532 Therapeutic Writing for Adults Suffering From Chronic Pain and Comorbid Mental Health… · Toni Salikka
2026-08-14
Trial terminated
Trial terminated: For logistical reasons at one study site.
Enrollment reduced: 60 → 41 participants
Primary completion pushed: 2024-12 → 2025-03-30
NCT06118606 Pilot Study of a Multidisciplinary Intervention in ICU Survivors at Risk for… · Region Stockholm
2026-08-19
Withdrawn before enrolling
Trial withdrawn: The collaborator has no intention to initiate the study at this moment.
Enrollment reduced: 200 → 0 participants
NCT06924814 Technology-Based Distractions for Minor Procedures · Stanford University
2026-08-14
Trial status changed: Recruiting → Withdrawn
Trial withdrawn: operational constraints beyond control of the study staff has forced the closure of the study.
Enrollment reduced: 40 → 0 participants
NCT07694934 Operation Calm: VR Nature-Based Mindfulness to Reduce Pediatric Surgical Anxiety · McGill University
2026-08-12
Trial terminated
Trial terminated: The study was terminated due to limited resources and the loss of key study personnel, which made completion of the pla...
Enrollment reduced: 60 → 14 participants
Primary completion moved earlier: 2028-04 → 2023-12-31
Completion moved earlier: 2028-12 → 2023-12-31
NCT05388110 SKY Breath Intervention · University of California, San Francisco
2026-08-11
Recruitment suspended
Recruitment suspended: Funding for this study was discontinued by the sponsor after the first year.
Primary completion pushed: 2026-12 → 2028-12-31
Completion pushed: 2026-12 → 2028-12-31
NCT05541887 Use Muscadine Wine Nutraceuticals to Improve Brain Health, Cognition, and Mental Health · University of Florida
2026-08-27
Primary completion pushed: 2025-10 → 2026-01-31
Completed without a posted recruiting period
Completion pushed: 2025-10 → 2026-01-31
NCT07081061 Clinical Outcomes of a Digital Mental Health Intervention for Moderate/Severe Depression… · Teladoc Health
2026-08-19
Primary completion pushed: 2027-06 → 2027-10-14
Trial sites reduced: 60 → 51 locations
Completion pushed: 2027-06 → 2027-10-14
NCT06701903 Study of ITI-1284 as Monotherapy Treatment in Patients With Generalized Anxiety Disorder · Intra-Cellular Therapies, Inc. · Phase 2
2026-09-04
Primary completion pushed: 2027-12-01 → 2028-12-01
Completion pushed: 2028-12-01 → 2029-12-01
NCT05437705 Decoding and Modulating Affective Brain States · University of Pennsylvania
2026-09-04
Primary completion pushed: 2026-06 → 2026-10
Completion pushed: 2027-02 → 2027-06
NCT06587230 Teachers Leading the Front Lines - North Carolina (Tealeaf-NC) · University of North Carolina, Chapel Hill
2026-08-21
Primary completion pushed: 2026-05-01 → 2026-08-30
Completion pushed: 2026-05-01 → 2026-08-30
NCT06708715 Stress Reduction After Use of a Haptic Vibrotactile Trigger Technology Patch: Analysis… · SuperPatch Limited LLC
2026-09-01
Primary completion pushed: 2026-12 → 2027-06
NCT05809115 Neurodevelopmental Outcomes in Children: Strengthening the Caregiver-Child Story · Baylor College of Medicine
2026-08-15
Primary completion pushed: 2025-12 → 2027-12
NCT04014829 Evaluation of Central Sensitization, Fear-Avoidance, and Pain-Pressure Threshold With… · KK Women's and Children's Hospital
2026-08-08
Primary completion pushed: 2026-10 → 2027-12
Recruitment opened
NCT06929208 Heart Rate Variability and Music Listening · KK Women's and Children's Hospital
2026-08-08
Primary completion pushed: 2025-08-31 → 2026-08-31
Completion pushed: 2026-12-31 → 2027-12-31
NCT03226028 Perioperative Music Listening on Anxiety, Analgesia Use and Patient Satisfaction · KK Women's and Children's Hospital
2026-08-08
Primary completion pushed: 2025-12-31 → 2026-12-31
Completion pushed: 2026-12-31 → 2027-12-31
NCT03415620 Perioperative Music Listening on Anxiety, Pain, Analgesia Use and Patient Satisfaction · KK Women's and Children's Hospital
2026-08-08
Primary completion pushed: 2025-12-31 → 2026-12-31
Completion pushed: 2026-12-31 → 2027-12-31
NCT03408717 Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery · KK Women's and Children's Hospital
2026-08-08
Primary completion pushed: 2025-12-31 → 2027-05-31
Completion pushed: 2026-08-31 → 2027-12-31
NCT03685422 Preoperative Virtual Reality to Reduce Pain on Gynaecologic Patients Undergoing Surgery · KK Women's and Children's Hospital
2026-08-28
Primary completion pushed: 2026-08-31 → 2027-11-01
Completion pushed: 2026-08-31 → 2027-11-01
NCT07228299 Supporting Families in the ICU · Indiana University

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-04 NCT07805018 EFFECT OF VIRTUAL REALITY GLASSES ON ANXIETY AND PAIN DURING DOUBLE J STENT REMOVAL VOLKAN ENES ÇELİK new
2026-09-04 NCT07805720 Acupressure for Pain and Anxiety After Cesarean Section University of Medicine and Pharmacy at Ho Chi Minh City new
2026-09-03 NCT07801391 Personalized and Accelerated Transcranial Magnetic Stimulation for Treatment-resistant… National University Hospital, Singapore new
2026-09-03 NCT07803367 Nature Photography for Mental Well-Being and Nature Connectedness in Young Adults Beijing Normal University new
2026-09-02 NCT07801014 The Impact of Dexmedetomidine Nasal Spray on Perioperative Anxiety in Neurosurgical… Beijing Tiantan Hospital new
2026-09-02 NCT07799493 Caplyta Versus Placebo for Adults With Social Anxiety Disorder Jason Careri new Phase 4
2026-09-01 NCT07798063 Effectiveness of Solution-Focused Therapy for Generalized Anxiety Disorder in Emerging… International Islamic University, Islamabad new
2026-08-27 NCT07789808 Activating Voice Journaling for Mental Health With Voice Biomarkers Kintsugi Mindful Wellness, Inc. new
2026-08-27 NCT07790029 Passiflora Incarnata for Dental Extraction Anxiety Ömer faruk Kaygısız new
2026-08-27 NCT07790055 The Effect of Mindfulness in Inflammation Markers (IL-6, TNF-A, CRP and Cortisol) Among… Natalia Dewi Wardani, MD new

Active trials by phase

Early Phase 1
9
Phase 1
7
Phase 1/2
5
Phase 2
48
Phase 2/3
6
Phase 3
20
Phase 4
23
Not charted: 1,422 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 1,540

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07542730 Diphenhydramine as an Adjunct to Moderate Sedation for Procedural First Trimester… University of Rochester Recruiting 2026-08-21
NCT07552246 Comparing Acupuncture With Medication to Reduce Depression, Anxiety and Comorbid Sleep… Duke Kunshan University Recruiting 2026-07-29
NCT07432815 Treatment of Psoriasis With Depression and/or Anxiety With Methotrexate vs Combined… Cairo University Recruiting 2026-05-05
NCT05895383 Self-Adjusted Nitrous Oxide: A Feasibility Study in the Setting of Vasectomy Beth Israel Deaconess Medical Center Recruiting 2026-02-06
NCT07182890 Efficacy of Clostridium Butyricum in Alleviating Anxiety and Depression in Patients With… Xijing Hospital of Digestive Diseases Recruiting 2026-01-05
NCT07187492 Efficacy of Bacillus Coagulans in Alleviating Anxiety and Depression in Patients With… Xijing Hospital of Digestive Diseases Recruiting 2026-01-05
NCT06853431 Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine… Second Affiliated Hospital of Wenzhou Medical University Recruiting 2025-12-02
NCT06004115 Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid… Laureate Institute for Brain Research, Inc. Recruiting 2025-10-31
NCT07192367 Comparison of the Effectiveness Level of Virtual Reality Exposure Therapy With Sertraline… Emine Kanmaz Recruiting 2025-09-25
NCT07113080 Assessing the Efficacy of Lemongrass and Lavender Aromatherapy in Reducing Dental Anxiety… Hiba Ahmed Eltayeb Recruiting 2025-08-08
NCT06843044 Efficacy and Safety of Ranquilon in Patients With Anxiety Disorders Due to Neurasthenia… Valenta Pharm JSC Recruiting 2025-07-08
NCT06218030 Adjunctive Treatment With L-methylfolate for Treatment-Resistant Generalized Anxiety… Queen's University Recruiting 2025-05-25
NCT04221997 Trial With the Treatment of Sertraline in Youth With Generalized, Separation and/or… University of Cincinnati Recruiting 2024-11-01
NCT04245436 Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety (AtLAS-A) University of Cincinnati Recruiting 2024-08-29
NCT04623099 Pharmacogenetically-guided Escitalopram Treatment for Pediatric Anxiety: Aiming to… University of Cincinnati Recruiting 2024-08-29
NCT07439042 Buspirone for Anxiety in Autistic Youth Massachusetts General Hospital Not Yet Recruiting 2026-09-04
NCT07799493 Caplyta Versus Placebo for Adults With Social Anxiety Disorder Jason Careri Not Yet Recruiting 2026-09-02
NCT07753772 Dexmedetomidine-Esketamine Combination on Depression and Anxiety After Laparoscopic… Peking University First Hospital Not Yet Recruiting 2026-08-14
NCT06786429 Managing Hepatitis B (Hep. B) and Human Papilloma Virus (HPV) Related Cancers and Mental… Eunice Dube Not Yet Recruiting 2026-07-30
NCT07651956 Remimazolam Versus Dexmedetomidine for Sedation During Neuraxial Icahn School of Medicine at Mount Sinai Not Yet Recruiting 2026-07-28
NCT06787976 Effect of Dolutegravir Compared With Darunavir/Cobicistat on the Severity of… Instituto Mexicano del Seguro Social Not Yet Recruiting 2025-06-26
NCT06896721 Effects of Nasal Administration of Dexmedetomidine on Pre-anesthesia Sedation… Fuzhou Hua Not Yet Recruiting 2025-03-26
NCT04751864 Brain Stimulation & Generalized Anxiety Study ProofPilot Active, Not Recruiting 2021-02-12
Phase 3
NCT07767903 A Trial of the Efficacy and Safety of a Fixed Dose of SEP-363856 in Adults With… Otsuka Pharmaceutical Development & Commercialization, Inc. Recruiting 2026-08-17
NCT07759128 A Trial of the Efficacy and Safety of Fixed Doses of SEP-363856 in Adults With… Otsuka Pharmaceutical Development & Commercialization, Inc. Recruiting 2026-08-12
See all 1,540 active Anxiety trials with filters →

Top sponsors by active trials in this area

Massachusetts General Hospital (19) · Karolinska Institutet (14) · Istanbul University - Cerrahpasa (13) · University of California, Los Angeles (11) · The University of Hong Kong (10) · Cairo University (9) · Ohio State University (9) · Stanford University (9) · University of Regina (9) · VA Office of Research and Development (9)

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