Impact of Exogenous Ketones on Breathing in Healthy Volunteers

Exogenous ketones (EK) are compounds that can increase the level of ketones in the body without needing to change what an individual eats. Although EK have been researched mainly in relation to energy and exercise, there haven't been many studies focusing specifically on how EKs affect breathing using well-established scientific methods. The investigators believe that EK may help improve breathing, which could be beneficial for situations like high altitudes, sleep apnea, and exercise. To explore how EK might influence breathing, the investigators are conducting a randomized, placebo-controlled crossover study with healthy volunteers.

NCT Number	NCT07220122
Lead Sponsor	Johns Hopkins University
Conditions	Healthy Volunteer
Enrollment	20 participants
Start Date	2026-03-12
Primary Completion	2027-01-10 (estimated)
Study Completion	2027-02-10 (estimated)
Updated on ClinicalTrials.gov	2026-03-31