Scrambler Therapy in Chronic Pancreatitis

The investigators will enroll adults with chronic pancreatitis who have persistent abdominal pain not relieved by standard treatments. This study will test the feasibility and effectiveness of Scrambler Therapy, a non-invasive FDA-cleared device that delivers "non-pain" electrical signals through the skin to retrain the brain's pain perception. Participants will undergo 5-10 treatment sessions and be followed for 3 months with standardized pain scores and quality-of-life assessments. The goal is to generate pilot data to support larger studies of Scrambler Therapy as a novel option for pancreatic pain.

NCT Number	NCT07174609
Lead Sponsor	Johns Hopkins University Collaborators: The National Pancreas Foundation
Conditions	Chronic Pain, Pancreatitis, Chronic Pancreatitis
Enrollment	40 participants
Start Date	2024-11-01
Primary Completion	2026-12-01 (estimated)
Study Completion	2026-12-01 (estimated)
Updated on ClinicalTrials.gov	2025-09-16