University of Colorado, Denver Clinical Trial Pipeline: 361 Active Trials, 48 Changes This Month

25 trials changed in the last 30 days: 0 stopped, 13 with notable changes, 12 with minor changes only.

Notable

Use of Pulsatile Intravenous FSH to Mitigate Reprometabolic Syndrome

Primary completion pushed from Nov 2025 to Nov 2031

Also in this update: Primary endpoint(s) modified; Enrollment increased: 5 → 60 participants

University of Colorado, DenverPhase 1 NCT06414096 Registry history of NCT06414096 on ClinicalTrials.gov (opens the registry)

Oct 14, 2026
Notable

CBD Extract for RLS Treatment

Primary completion pushed from Jan 1, 2026 to Mar 14, 2028

Also in this update: Study completion pushed from Feb 25, 2026 to Jun 1, 2028

University of Colorado, DenverPhase 2 NCT07224932 Registry history of NCT07224932 on ClinicalTrials.gov (opens the registry)

Oct 8, 2026
Notable

DIVE · Sympathetic Nervous System Function · Down Syndrome

Primary completion pushed from Dec 2028 to Dec 2029

Also in this update: Primary endpoint(s) modified; Study completion pushed from Dec 2029 to Dec 2030

University of Colorado, DenverPhase 3 NCT07238465 Registry history of NCT07238465 on ClinicalTrials.gov (opens the registry)

Sep 28, 2026
Notable

SMART 2D · Montelukast's Effects on Renal and Cardiovascular Health in Adolescents and Young · Type 2 Diabetes

Primary completion pushed from Feb 2030 to Dec 2030

Also in this update: Start date pushed from Aug 7, 2026 to Oct 12, 2026; Study completion pushed from Feb 2030 to Dec 2031

University of Colorado, DenverEarly Phase 1 NCT07409714 Registry history of NCT07409714 on ClinicalTrials.gov (opens the registry)

Oct 6, 2026
Notable

Puberty, Testosterone, and Brain Development

Primary completion pushed from Jun 2026 to Jun 2028

Also in this update: Study completion pushed from Dec 2026 to Jan 2029

University of Colorado, DenverNot specified NCT06670053 Registry history of NCT06670053 on ClinicalTrials.gov (opens the registry)

Sep 21, 2026
Notable

Omacetaxine + Azacitidine · High Grade MDS

Primary endpoint(s) modified

Also in this update: Results posted: Sep 29, 2026; Trial arms changed: 2 → 6

University of Colorado, DenverPhase 1/2 NCT03564873 Registry history of NCT03564873 on ClinicalTrials.gov (opens the registry)

Sep 29, 2026
Notable

Integrated Mental Health Care for Pregnant · HIV in Kenya: The Tunawiri Study

Primary endpoint(s) modified

University of Colorado, DenverNot applicable NCT06117163 Registry history of NCT06117163 on ClinicalTrials.gov (opens the registry)

Oct 8, 2026
Notable

Decision Support in Opioid Tapering

Primary endpoint(s) modified

Also in this update: Primary completion pushed from Dec 2026 to Mar 2027; Interventions modified

University of Colorado, DenverNot specified NCT06527079 Registry history of NCT06527079 on ClinicalTrials.gov (opens the registry)

Sep 30, 2026
Notable

APOYO780G · Supporting Medtronic 780G Insulin Pump Adoption in Latino Patients: A Spanish - Language Training Initiative

Recruitment opened

Also in this update: Primary completion pushed from Jan 2027 to Jul 2027; Study completion pushed from Mar 2027 to Oct 2027

University of Colorado, DenverNot applicable NCT07720388 Registry history of NCT07720388 on ClinicalTrials.gov (opens the registry)

Oct 8, 2026
Notable

Transcranial Magnetic Stimulation on Social Cognition, Cognitive Processing, and Functional Brain Architecture

Recruitment opened

University of Colorado, DenverNot applicable NCT07635940 Registry history of NCT07635940 on ClinicalTrials.gov (opens the registry)

Sep 29, 2026
Notable

Decision Support to Increase Use of Medications for Opioid Use Disorder

Recruitment opened

Also in this update: Primary completion pushed from Nov 2026 to Jan 2027

University of Colorado, DenverNot specified NCT06526286 Registry history of NCT06526286 on ClinicalTrials.gov (opens the registry)

Sep 21, 2026
Notable

SAVE-O2 AI · Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention

Results posted: Oct 14, 2026

University of Colorado, DenverNot applicable NCT06374225 Registry history of NCT06374225 on ClinicalTrials.gov (opens the registry)

Oct 14, 2026
Notable

Contrast Agents in Liver Magnetic Resonance (MR) for the Detection of Hepatic Metastases

Results posted: Sep 25, 2026

University of Colorado, DenverPhase 4 NCT04973007 Registry history of NCT04973007 on ClinicalTrials.gov (opens the registry)

Sep 25, 2026

Show 12 trials with minor changes only

Minor

Smart Underwear to Measure Diet-Induced Hydrogen Sulfide Production

Trial completed

Also in this update: Final enrollment: 30 participants (planned 25); Primary completion date changed from estimate of Jun 1, 2027 to Jul 22, 2026

University of Colorado, DenverNot applicable NCT06802276 Registry history of NCT06802276 on ClinicalTrials.gov (opens the registry)

Oct 19, 2026
Minor

THC on Alcohol Consumption and Neural Correlates of Reward

Trial status changed: Unknown → Recruiting

University of Colorado, DenverPhase 2 NCT06446479 Registry history of NCT06446479 on ClinicalTrials.gov (opens the registry)

Aug 19, 2024
Minor

Neuronal and Behavioral Effects of an Implicit Priming Approach to Improve Eating Behaviors in Obesity

Trial completed

Also in this update: Final enrollment: 161 participants (planned 228)

University of Colorado, DenverNot applicable NCT05107908 Registry history of NCT05107908 on ClinicalTrials.gov (opens the registry)

Oct 7, 2026
Minor

Decision Support to Improve System Naloxone Co-prescribing

Trial completed

Also in this update: Final enrollment: 114272 participants (planned 200000); Study completion date changed from estimate of Oct 2026 to Apr 1, 2026

University of Colorado, DenverNot specified NCT06271668 Registry history of NCT06271668 on ClinicalTrials.gov (opens the registry)

Sep 29, 2026
Minor

Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients

Primary completion pushed from Aug 31, 2026 to Sep 30, 2026

University of Colorado, DenverNot applicable NCT06501118 Registry history of NCT06501118 on ClinicalTrials.gov (opens the registry)

Sep 28, 2026
Minor

Decision Support for Safety of Opioid Transitions

Primary completion pushed from Dec 2026 to Apr 2027

University of Colorado, DenverNot specified NCT06527040 Registry history of NCT06527040 on ClinicalTrials.gov (opens the registry)

Sep 21, 2026
Minor

Amivantamab With Tyrosine Kinase Inhibitors (TKI) for Advanced NSCLC With ALK, ROS1, or RET Alterations

Primary completion date changed from estimate of Jan 2027 to Sep 23, 2026

University of Colorado, DenverPhase 1/2 NCT05845671 Registry history of NCT05845671 on ClinicalTrials.gov (opens the registry)

Sep 29, 2026
Minor
5 trials marked Unknown by the registry's verification sweep
1. Minor
  
  Outcomes for Lumbar Decompressions With Use of Liposomal Bupivicaine
  
  Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Recruiting
  
  University of Colorado, DenverPhase 2 NCT04066296 Registry history of NCT04066296 on ClinicalTrials.gov (opens the registry)
  
  Changed Oct 4, 2026
2. Minor
  
  No Strings Intrauterine Device (IUD) Removal Techniques
  
  Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Active, Not Recruiting
  
  University of Colorado, DenverNot applicable NCT05702242 Registry history of NCT05702242 on ClinicalTrials.gov (opens the registry)
  
  Changed Oct 4, 2026
3. Minor
  
  One-4-ALL Initiative
  
  Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Recruiting
  
  University of Colorado, DenverNot applicable NCT05454969 Registry history of NCT05454969 on ClinicalTrials.gov (opens the registry)
  
  Changed Oct 4, 2026
4. Minor
  
  INSIGHTS · Inspiring New Science In Guiding Healthcare in Turner Syndrome Registry
  
  Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Recruiting
  
  University of Colorado, DenverNot specified NCT05052606 Registry history of NCT05052606 on ClinicalTrials.gov (opens the registry)
  
  Changed Oct 4, 2026
5. Minor
  
  SUNRISE · Impact of Sleep Extension in Adolescents
  
  Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Active, Not Recruiting
  
  University of Colorado, DenverNot applicable NCT03500458 Registry history of NCT03500458 on ClinicalTrials.gov (opens the registry)
  
  Changed Oct 4, 2026
Registry verification sweep

Changed Oct 4, 2026

Stopped: an ongoing trial was terminated, suspended or withdrawn.
Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
Minor: routine progress and housekeeping, such as sites added or enrollment closed.

First posted	Trial	Phase	Status
2026-10-13	NCT07872384 Supplemental Mobility		Not Yet Recruiting
2026-10-09	NCT07868471 Community Active and Healthy Families Pragmatic Trial	Phase 4	Not Yet Recruiting
2026-10-05	NCT07858162 Prospective Silent Evaluation of AI for Retained Foreign Object Detection		Recruiting
2026-09-28	NCT07844629 Comparing Rectal Artery Embolization and Surgery for Treatment of Bleeding Grade 2 and 3…	Phase 2	Not Yet Recruiting
2026-09-21	NCT07831499 Cyclic vs. Constant Estradiol: Regimens' Effects on Brain Health	Phase 4	Recruiting

University of Colorado, Denver clinical trial pipeline

What changed in the last 30 days

Use of Pulsatile Intravenous FSH to Mitigate Reprometabolic Syndrome

CBD Extract for RLS Treatment

DIVE · Sympathetic Nervous System Function · Down Syndrome

SMART 2D · Montelukast's Effects on Renal and Cardiovascular Health in Adolescents and Young · Type 2 Diabetes

Puberty, Testosterone, and Brain Development

Omacetaxine + Azacitidine · High Grade MDS

Integrated Mental Health Care for Pregnant · HIV in Kenya: The Tunawiri Study

Decision Support in Opioid Tapering

APOYO780G · Supporting Medtronic 780G Insulin Pump Adoption in Latino Patients: A Spanish - Language Training Initiative

Transcranial Magnetic Stimulation on Social Cognition, Cognitive Processing, and Functional Brain Architecture

Decision Support to Increase Use of Medications for Opioid Use Disorder

SAVE-O2 AI · Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention

Contrast Agents in Liver Magnetic Resonance (MR) for the Detection of Hepatic Metastases

Smart Underwear to Measure Diet-Induced Hydrogen Sulfide Production

THC on Alcohol Consumption and Neural Correlates of Reward

Neuronal and Behavioral Effects of an Implicit Priming Approach to Improve Eating Behaviors in Obesity

Decision Support to Improve System Naloxone Co-prescribing

Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients

Decision Support for Safety of Opioid Transitions

Amivantamab With Tyrosine Kinase Inhibitors (TKI) for Advanced NSCLC With ALK, ROS1, or RET Alterations

Outcomes for Lumbar Decompressions With Use of Liposomal Bupivicaine

No Strings Intrauterine Device (IUD) Removal Techniques

One-4-ALL Initiative

INSIGHTS · Inspiring New Science In Guiding Healthcare in Turner Syndrome Registry

SUNRISE · Impact of Sleep Extension in Adolescents

New trial filings, last 30 days

Active trials by phase

Disease areas by active trials, top 10 of 55

Early Phase 1		9
Phase 1		16
Phase 1/2		11
Phase 2		40
Phase 2/3		2
Phase 3		10
Phase 4		23