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Evaluation of Clinical Decision Support in Opioid Tapering

StatusNot Yet Recruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 2 months later Dec 2026 → Mar 2027
Primary endpoint reworded 1 of 1 changed
See other at-risk trials from University of Colorado, Denver

Record History

  1. Primary endpoint(s) modified Start date: Aug 2026 to Nov 2026 · Primary completion pushed from Dec 2026 to Mar 2027 · Interventions modified · 3 more Show 6 more changesShow less
    • Start date: Aug 2026 to Nov 2026
    • Primary completion pushed from Dec 2026 to Mar 2027
    • Interventions modified
    • Trial arms changed: 2 → 1
    • Eligibility criteria expanded, about 6 words
    • Secondary endpoints: 3 to 2
  2. Start date: Feb 2026 to Aug 2026v8
  3. Start date: Dec 2025 to Feb 2026v7
  4. Primary completion date: Nov 2026 to Dec 2026 Completion date: May 2027 to Jun 2027v6 Show 1 more changeShow less
    • Completion date: May 2027 to Jun 2027
  5. Start date: May 2025 to Dec 2025v5
Show 3 earlier versionsHide 3 earlier versions
  1. Primary completion date: Apr 2026 to Nov 2026 Start date: Oct 2024 to May 2025 · Completion date: Oct 2026 to May 2027v4 Show 2 more changesShow less
    • Start date: Oct 2024 to May 2025
    • Completion date: Oct 2026 to May 2027
  2. Collaborators reorderedv3
  3. Re-verified, no change to tracked fieldsv2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The 2022 Center for Disease Control and Prevention (CDC) clinical practice guideline for prescribing opioids for pain recommends that when tapering a patient's opioid dose, doses should be decreased at a slow rate to reduce the risk of withdrawal symptoms, overdose, and to promote tolerance of the tapering. This project will examine the state of tapering in primary care across the system as well as conduct stakeholder interviews to understand the resources available across the system to support providers in tapering and identify opportunities for clinical decision support to be implemented to support guideline concordant tapering. Utilization of a clinical care pathway that gives providers information, recommendations, and educational material on strategies for opioid tapering will be examined. The rate of opioid tapering in line with CDC guidelines will be examined as well as long term patient outcomes of opioid overdose of poisoning using existing patient health records. The study period will be approximately 8 months.
Trial Details
NCT Number NCT06527079
Lead Sponsor University of Colorado, Denver
Collaborators: National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH)
Conditions Medication Abuse, Harm Reduction, Opioid Use Disorder, Opioid Prescribing, Opioid Overdose, Prevention
Enrollment 200,000 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov