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Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients

StatusActive, Not Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated September 28, 2026 (before its estimated September 30, 2026 completion). Its status may not reflect the trial's current state.
Trial flagged as At Risk
Primary completion moved at least 2 months later across 2 updates Jul 8, 2026 → Sep 30, 2026
See other at-risk trials from University of Colorado, Denver

Record History

  1. Primary completion pushed from Aug 31, 2026 to Sep 30, 2026
  2. Enrollment closed, study ongoing Completion pushed from Oct 15, 2026 to Nov 30, 2026 · Primary completion date changed from estimate of Sep 1, 2026 to Aug 31, 2026 · Eligibility criteria expanded, about 6 words · 4 more Show 7 more changesShow less
    • Completion pushed from Oct 15, 2026 to Nov 30, 2026
    • Primary completion date changed from estimate of Sep 1, 2026 to Aug 31, 2026
    • Eligibility criteria expanded, about 6 words
    • Secondary endpoints: details revised at 4 of 11 entries
    • Site details revised
    • Publications: details revised at 31 of 31 entries
    • Study description expanded, about 2 words
  3. Primary completion pushed from Jul 8, 2026 to Sep 1, 2026 Completion pushed from Jul 31, 2026 to Oct 15, 2026v10 Show 1 more changeShow less
    • Completion pushed from Jul 31, 2026 to Oct 15, 2026
  4. Primary endpoint(s) modified Primary completion date: Jun 30, 2026 to Jul 8, 2026 · Secondary endpoints revised (11) · Study description expanded, about 26 wordsv9 Show 3 more changesShow less
    • Primary completion date: Jun 30, 2026 to Jul 8, 2026
    • Secondary endpoints revised (11)
    • Study description expanded, about 26 words

    See this version in full on ClinicalTrials.gov ↗

  5. Eligibility criteria expanded, about 9 wordsv8 See this version in full on ClinicalTrials.gov ↗
Show 6 earlier versionsHide 6 earlier versions
  1. Trial status: Active, Not Recruiting to Recruiting Primary completion date: Aug 1, 2025 to Jun 30, 2026 · Interventions: Education (Other) to Education (Other), Epic notification alert (Behavioral) · Secondary endpoints: 8 to 11 · 3 morev7 Show 6 more changesShow less
    • Primary completion date: Aug 1, 2025 to Jun 30, 2026
    • Interventions: Education (Other) to Education (Other), Epic notification alert (Behavioral)
    • Secondary endpoints: 8 to 11
    • Study description expanded, about 167 words
    • Site details revised
    • Study arms: 1 to 2

    See this version in full on ClinicalTrials.gov ↗

  2. Trial status: Completed to Active, Not Recruiting Completion date: Aug 1, 2025 to Jul 31, 2026v6 Show 1 more changeShow less
    • Completion date: Aug 1, 2025 to Jul 31, 2026
  3. Trial status: Recruiting to Completed Start date: Sep 4, 2024 to Sep 1, 2024 · Site details revisedv5 Show 2 more changesShow less
    • Start date: Sep 4, 2024 to Sep 1, 2024
    • Site details revised
  4. Trial status: Not Yet Recruiting to Recruiting Primary and study completion dates: Aug 1, 2026 to Aug 1, 2025 · Study sites: 0 to 1 · Start date changed from estimate of Aug 1, 2024 to Sep 4, 2024 · 1 morev4 Show 4 more changesShow less
    • Primary and study completion dates: Aug 1, 2026 to Aug 1, 2025
    • Study sites: 0 to 1
    • Start date changed from estimate of Aug 1, 2024 to Sep 4, 2024
    • Secondary endpoints: details revised at 1 of 8 entries
  5. Study description revisedv3 See this version in full on ClinicalTrials.gov ↗
  6. Study description expanded, about 2 wordsv2 See this version in full on ClinicalTrials.gov ↗
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
A multimodal educational intervention to target an oxygen saturation target range (SpO2 90-96%) will reduce ventilator length of stay and reduce occult hypoxemia by increased awareness and adherence to a designated oxygen saturation target range.
Trial Details
NCT Number NCT06501118
Lead Sponsor University of Colorado, Denver
Conditions Respiratory Failure, Acute Hypoxemic Respiratory Failure, Acute Hypoxic Respiratory Failure, Hypoxemia, Hypoxia, Hypoxic Respiratory Failure
Enrollment 3,600 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov