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Mayo Clinic clinical trial pipeline

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Data updated daily from ClinicalTrials.gov, last refresh 2026-10-20

What changed in the last 30 days

93 trials changed in the last 30 days: 2 stopped, 59 with notable changes, 32 with minor changes only.

  1. Stopped

    Utilization of a Shoe Insert on · Unilateral Greater Trochanteric Pain Syndrome on Single Leg Stance, Biomechanics, and Pain Intensity

    Withdrawn before enrolling

    Also in this update: Primary completion pushed from Jan 1, 2028 to Oct 5, 2028; Study completion moved earlier from Jan 1, 2029 to Oct 5, 2028

    Mayo ClinicNot applicable NCT06891001 Registry history of NCT06891001 on ClinicalTrials.gov (opens the registry)

Show 32 trials with minor changes only
  1. Minor

    Acalabrutinib, Venetoclax and Durvalumab · Richter Transformation From Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

    Enrollment closed, study ongoing

    Also in this update: Primary completion date changed from estimate of Feb 22, 2027 to Sep 23, 2026; Study completion pushed from Feb 22, 2027 to Mar 30, 2031

    Mayo ClinicPhase 2 NCT05388006 Registry history of NCT05388006 on ClinicalTrials.gov (opens the registry)

  2. Minor

    Remote Cognitive Assessment and Wearable Device While Assessing the Impact of Metformin · History of Cranial Radiation Therapy

    Enrollment closed, study ongoing

    Also in this update: Primary completion moved earlier from May 1, 2027 to Feb 1, 2027; Study completion pushed from May 1, 2027 to Feb 1, 2028

    Mayo ClinicPhase 2 NCT06377696 Registry history of NCT06377696 on ClinicalTrials.gov (opens the registry)

  3. Minor

    Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) Combined With Immune Checkpoint Inhibition After High-Dose External Beam Radiation Therapy · Unresectable Liver Cancer

    Primary completion pushed from May 31, 2030 to Aug 31, 2030

    Also in this update: Study completion moved earlier from Feb 28, 2031 to Aug 31, 2030

    Mayo ClinicPhase 1/2 NCT03942328 Registry history of NCT03942328 on ClinicalTrials.gov (opens the registry)

  4. Minor

    Alternative Site Goserelin Acetate Injection for Ovarian Function Suppression (OFS) in Local and Locally Advanced Premenopausal Hormone Receptor Positive Breast Cancer Patients

    Primary completion pushed from Sep 26, 2028 to Dec 21, 2028

    Also in this update: Study completion moved earlier from Sep 26, 2029 to Jun 21, 2029

    Mayo ClinicPhase 2 NCT07460752 Registry history of NCT07460752 on ClinicalTrials.gov (opens the registry)

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-10-19 NCT07879872 Conducting Wound, Ostomy, and Continence (WOC) Nurse Telephone Follow-up for… Recruiting
2026-10-16 NCT07879014 Evaluating the Efficacy of a "Quiet Knee Protocol" in Primary Total Knee Arthroplasty… Recruiting
2026-10-15 NCT07874841 Varenicline for Smoking Cessation in Pancreatitis Phase 4 Not Yet Recruiting
2026-10-09 NCT07868614 Intraoperative Microelectrode Recordings Using MAVEN Compared to Standard Recording… Recruiting
2026-10-07 NCT07862205 EEG-Guided Transcranial Magnetic Stimulation for Adults With Depression Not Yet Recruiting
2026-10-02 NCT07856394 Adding Spatially Fractionated Radiation Therapy to Standard Palliative Radiation for… Recruiting
2026-09-30 NCT07850284 SMS-Based Remote Symptom Monitoring for Patients With Plasma Cell Disorders Recruiting
2026-09-28 NCT07843420 Nemolizumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus Phase 2 Not Yet Recruiting
2026-09-24 NCT07838324 A Pilot Investigation of Pain Reprocessing Therapy for Functional Dyspepsia Recruiting
2026-09-24 NCT07840144 Lower Body Negative Pressure to Validate Physiological Monitors Recruiting

Active trials by phase

Early Phase 1
19
Phase 1
37
Phase 1/2
17
Phase 2
107
Phase 2/3
3
Phase 3
12
Phase 4
51
Not charted: 573 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Disease areas by active trials, top 10 of 68

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