Alliance for Clinical Trials in Oncology clinical trial pipeline

26 trials changed in the last 30 days: 0 stopped, 8 with notable changes, 18 with minor changes only.

1. Notable

   Laser Therapy · Vaginal Dryness in Survivors of Breast Cancer, The…Laser Therapy · Vaginal Dryness in Survivors of Breast Cancer, The Revitalize Trial

   Primary completion pushed from Sep 2026 to Aug 30, 2029

   Also in this update: Study completion pushed from May 2027 to Apr 30, 2030

   Alliance for Clinical Trials in Oncology·Phase 3· NCT05379153· Registry history of NCT05379153 on ClinicalTrials.gov (opens the registry)

   Oct 19, 2026

2. Notable

   Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young…Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young · Newly Diagnosed B Acute Lymphoblastic Leukemia

   Primary completion pushed from Mar 1, 2027 to Nov 1, 2027

   Also in this update: Study completion pushed from Aug 2027 to Apr 1, 2028

   Alliance for Clinical Trials in Oncology·Phase 3· NCT03150693· Registry history of NCT03150693 on ClinicalTrials.gov (opens the registry)

   Oct 19, 2026

3. Notable

   Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung…Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Cancer After Treatment

   Primary completion pushed from Dec 31, 2028 to Dec 31, 2032

   Also in this update: Study completion pushed from Mar 1, 2032 to Mar 1, 2036; and 1 more change in the last 30 days

   Alliance for Clinical Trials in Oncology·Phase 2· NCT07293247· Registry history of NCT07293247 on ClinicalTrials.gov (opens the registry)

   Oct 19, 2026

4. Notable

   Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and…Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib · Progressive Meningiomas

   Primary completion pushed from Jan 1, 2027 to Jun 1, 2028

   Also in this update: Study completion pushed from Jan 2028 to Jun 1, 2029

   Alliance for Clinical Trials in Oncology·Phase 2· NCT02523014· Registry history of NCT02523014 on ClinicalTrials.gov (opens the registry)

   Oct 19, 2026

5. Notable

   Gemcitabine and Cisplatin Without Cystectomy · Muscle Invasive…Gemcitabine and Cisplatin Without Cystectomy · Muscle Invasive Bladder Urothelial Cancer and Select Genetic Alterations

   Primary completion pushed from Feb 1, 2027 to Oct 14, 2028

   Also in this update: Study completion pushed from Feb 1, 2029 to Oct 14, 2030

   Alliance for Clinical Trials in Oncology·Phase 2· NCT03609216· Registry history of NCT03609216 on ClinicalTrials.gov (opens the registry)

   Oct 16, 2026

6. Notable

   JANUS · Addition of an Anti-Cancer Drug, Irinotecan, to the…JANUS · Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation and Continuing Response

   Primary completion pushed from Sep 30, 2026 to Jul 1, 2030

   Also in this update: Study completion pushed from Sep 30, 2033 to Jul 1, 2037

   Alliance for Clinical Trials in Oncology·Phase 2/3· NCT05610163· Registry history of NCT05610163 on ClinicalTrials.gov (opens the registry)

   Sep 25, 2026

7. Notable

   PLATINUM Trial: Optimizing Chemotherapy for the Second-Line…PLATINUM Trial: Optimizing Chemotherapy for the Second-Line Treatment of Metastatic BRCA1/2 or PALB2-Associated Metastatic Pancreatic Cancer

   Primary completion moved earlier from Jan 15, 2029 to Dec 1, 2027

   Also in this update: Study completion moved earlier from Dec 9, 2029 to Jan 1, 2028

   Alliance for Clinical Trials in Oncology·Phase 2/3· NCT06115499· Registry history of NCT06115499 on ClinicalTrials.gov (opens the registry)

   Oct 19, 2026

8. Notable

   Finding an Effective Dose of GM1 to Reduce or Prevent Neuropathy…Finding an Effective Dose of GM1 to Reduce or Prevent Neuropathy (Numbness or Weakness) Due to Treatment With Paclitaxel

   Primary completion moved earlier from Mar 15, 2028 to Nov 15, 2026

   Also in this update: Study completion moved earlier from Mar 15, 2032 to Nov 15, 2028

   Alliance for Clinical Trials in Oncology·Phase 2· NCT05751668· Registry history of NCT05751668 on ClinicalTrials.gov (opens the registry)

   Oct 19, 2026

• Stopped: an ongoing trial was terminated, suspended or withdrawn.
• Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
• Minor: routine progress and housekeeping, such as sites added or enrollment closed.