Distance-Based Exercise to Preserve Function and Prevent Disability

Study acronym: DEFEND
StatusRecruiting
PhaseNot applicable
Started

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Record History

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  1. Trial sites expanded: 18 → 23 locations
    • Eligibility criteria expanded, about 17 words
    • Secondary endpoints: details revised at 1 of 2 entries
    • Study description expanded, about 4 words
  2. Study sites revised (18)v7
  3. Primary completion pushed from Jan 1, 2027 to Jul 1, 2027
    • Study completion pushed from Feb 18, 2027 to Aug 31, 2027
    • Study sites: 17 to 18
    v6
  4. Interventions: Accelerometry (Procedure), Aerobic Exercise Intervention (Other), Dumbbell Exercise Intervention (Other), Electronic Health Record Review… to Accelerometry (Procedure), Aerobic Exercise Intervention (Other), Electronic Health Record Review (Other), Exercise Intervention (Other)…
    • Eligibility criteria expanded, about 11 words
    • Study description expanded, about 70 words
    v5
  5. Trial sites expanded: 14 → 17 locationsv4
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  1. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 0 to 14
    • Start date changed from estimate of Feb 2026 to Feb 11, 2026
    v3
  2. Start date: Aug 23, 2025 to Feb 2026v2
  1. Study First Submitted
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Alliance for Clinical Trials in Oncology
87 trials monitored
See 11 trials at risk
Breast Cancer
5,455 trials monitored
See 306 trials at risk
Lung Cancer
4,798 trials monitored
See 270 trials at risk
Colorectal Cancer
3,405 trials monitored
See 162 trials at risk
and 12 more diseases
This clinical trial studies whether an exercise program can be successfully delivered to patients receiving treatment for cancer through virtual sessions and allow patients to exercise in their own home. Treatments for cancer can cause side effects such as fatigue and loss of strength. These side effects can make it difficult to work, take care of family, and do other things the patient wants to do. Preliminary research shows that exercise can help prevent some of these side effects, but it can be more difficult to start an exercise program when a patient is receiving cancer treatment. The exercise program in this study is delivered through telehealth (TH) video calls. The TH sessions are delivered by trained staff that supervise resistance exercises. The trained staff also provide guidance to the patient on completing unsupervised aerobic sessions on their own. This may be a successful way to deliver an exercise program and make it easier for cancer patients to exercise in their own home during treatment.
Trial Details
NCT Number NCT07059884
Lead Sponsor Alliance for Clinical Trials in Oncology
Collaborators: National Cancer Institute (NCI)
Conditions
(from sponsor)		 Localized Malignant Solid Neoplasm, Anal Cancer, Bladder (Urothelial, Transitional Cell) Cancer, Breast Cancer, Cervical Cancer, Colon Cancer, Endometrial Cancer, Esophageal Cancer +11 more
Related terms Anus Neoplasms, Breast Neoplasms, Colonic Neoplasms, Endometrial Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Sarcoma, Stomach Neoplasms, Uterine Cervical Neoplasms
Enrollment 104 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov