Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

StatusRecruiting
PhaseNot applicable
Started

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Record History

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  1. Trial sites expanded: 364 → 368 locations
    • Eligibility criteria expanded, about 29 words
    • Secondary endpoints: details revised at 3 of 3 entries
  2. Study sites: 363 to 364v7
  3. Trial sites expanded: 344 → 363 locationsv6
  4. Trial sites expanded: 316 → 344 locationsv5
  5. Trial sites expanded: 287 → 316 locationsv4
  6. Trial sites expanded: 271 → 287 locationsv3
  7. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 0 to 271
    • Start date changed from estimate of Dec 15, 2025 to Feb 13, 2026
    v2
  8. Study First Submitted
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study seeks to learn whether using the PAGODA algorithm to guide chemotherapy dosing will lower the chance of unplanned delays during chemotherapy for cancer in the gastrointestinal system compared to usual care.
Trial Details
NCT Number NCT07283939
Lead Sponsor Alliance for Clinical Trials in Oncology
Collaborators: National Cancer Institute (NCI)
Conditions
(from sponsor)		 Ampulla of Vater Carcinoma, Appendix Carcinoma, Carcinoma of Unknown Primary With Gastrointestinal Profile, Colon Carcinoma, Esophageal Carcinoma, Gastric Carcinoma, Gastroesophageal Junction Carcinoma, Malignant Digestive System Neoplasm +2 more
Related terms Appendiceal Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Rectal Neoplasms, Stomach Neoplasms
Enrollment 420 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov