Clinical Trial

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

Recruiting
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Summary
This study seeks to learn whether using the PAGODA algorithm to guide chemotherapy dosing will lower the chance of unplanned delays during chemotherapy for cancer in the gastrointestinal system compared to usual care.
Protocol Amendment History 4 changes
notable Trial sites expanded: 344 -> 363 locations 2026-08-06
notable Trial sites expanded: 316 -> 344 locations 2026-07-03
notable Trial sites expanded: 287 -> 316 locations 2026-05-12
notable Trial sites expanded: 271 -> 287 locations 2026-04-08
Trial Details
NCT Number NCT07283939
Lead Sponsor Alliance for Clinical Trials in Oncology
Collaborators: National Cancer Institute (NCI)
Conditions Ampulla of Vater Carcinoma, Appendix Carcinoma, Carcinoma of Unknown Primary With Gastrointestinal Profile, Colon Carcinoma, Esophageal Carcinoma, Gastric Carcinoma, Gastroesophageal Junction Carcinoma, Malignant Digestive System Neoplasm +2 more
Enrollment 420 participants
Start Date 2026-02-13
Primary Completion 2030-05-01 (estimated)
Study Completion 2030-05-02 (estimated)
Updated on ClinicalTrials.gov 2026-08-05