| Detected | Trial | Change |
|---|---|---|
| 2026-05-30 | NCT04561518 ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated… |
Primary endpoint(s) modified |
| 2026-05-30 | NCT04561518 ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated… |
date change Primary completion pushed: 2030-09-01 -> 2033-12-31 |
| 2026-05-30 | NCT04561518 ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated… |
date change Completion pushed: 2030-09-01 -> 2033-12-31 |
| 2026-05-15 | NCT07052903 TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With… |
Trial sites expanded: 207 -> 223 locations |
| 2026-05-15 | NCT07223203 TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With… |
Trial sites expanded: 4 -> 16 locations |
| 2026-05-15 | NCT07463846 A Study to Evaluate ALN-2232 in Participants With Obesity |
date change Primary completion moved earlier: 2028-02-01 -> 2027-04-27 |
| 2026-05-15 | NCT07181109 Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either… |
Trial sites expanded: 597 -> 742 locations |
| 2026-05-15 | NCT07553442 A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension… |
Recruitment opened |
| First Posted | Trial | Phase | Status |
|---|---|---|---|
| 2026-06-09 | NCT07636811 A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down… | Phase 2 | Not Yet Recruiting |
| 2026-06-03 | NCT07624071 A Study to Evaluate ALN-6222 in Participants With Obesity | Phase 1 | Not Yet Recruiting |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 3 | |||
| NCT07052903 | TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With… | Transthyretin Amyloidosis With Cardiomyopathy | Recruiting |
| NCT07181109 | Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either… | High Risk Cardiovascular Disease | Recruiting |
| NCT07223203 | TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With… | Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy | Recruiting |
| NCT04153149 | HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With… | Transthyretin Amyloidosis (ATTR) With Cardiomyopathy | Active, Not Recruiting |
| NCT06679946 | A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With… | Transthyretin Amyloidosis (ATTR) With Cardiomyopathy | Enrolling by Invitation |
| Phase 2 | |||
| NCT06393712 | A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy | Cerebral Amyloid Angiopathy | Recruiting |
| NCT07465224 | A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes… | Type 2 Diabetes Mellitus (T2DM) | Recruiting |
| NCT07553442 | A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension… | Hypertension | Recruiting |
| NCT07575308 | HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients… | Von Willebrand Disease (VWD) | Not Yet Recruiting |
| NCT07636811 | A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down… | Down Syndrome-Associated Alzheimer's Disease (DS-AD) | Not Yet Recruiting |
| Phase 1/2 | |||
| NCT06659640 | A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary… | Hereditary Hemorrhagic Telangiectasia | Recruiting |
| NCT06845202 | A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight… | Obese or Overweight Healthy Volunteers | Recruiting |
| NCT07463846 | A Study to Evaluate ALN-2232 in Participants With Obesity | Obesity | Recruiting |
| Phase 1 | |||
| NCT05231785 | A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD | Early-Onset Alzheimer Disease | Recruiting |
| NCT06585449 | A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease | Huntington's Disease | Recruiting |
| NCT07214727 | A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease | Alzheimer's Disease | Recruiting |
| NCT07295717 | A Study to Evaluate ALN-4285 in Adult Healthy Volunteers | Healthy Volunteers | Recruiting |
| NCT07535606 | A Study to Evaluate ALN-4915 in Adult Healthy Volunteers | Healthy Volunteers | Recruiting |
| NCT06600321 | A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma | Advanced Hepatocellular Carcinoma | Recruiting |
| NCT07624071 | A Study to Evaluate ALN-6222 in Participants With Obesity | Obesity | Not Yet Recruiting |
| Not specified | |||
| NCT07358078 | DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With… | Transthyretin Amyloidosis With Cardiomyopathy | Recruiting |
| NCT04883905 | ELEVATE, a Registry of Patients With Acute Hepatic Porphyria (AHP) | Acute Hepatic Porphyria | Recruiting |
| NCT04561518 | ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated… | Transthyretin-Mediated Amyloidosis | Recruiting |
| NCT05040373 | Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance Program | Hereditary Transthyretin-mediated (hATTR) Amyloidosis | Recruiting |
| NCT04982393 | BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type… | Primary Hyperoxaluria Type 1 | Active, Not Recruiting |