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A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran

Name: A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran — clinical trial record (NCT07553442)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

StatusRecruiting

PhasePhase 2

SponsorAlnylam Pharmaceuticals

Started2026-04-27

View on ClinicalTrials.gov ↗

Amendment history

2026-09-10

Study Status v5

Re-verified, no change to tracked fields

2026-08-12

Study Status, Contacts/Locations v4

Study sitesdetails revised at 2 of 3 sites

2026-07-22

Study Status v3

Re-verified, no change to tracked fields

2026-06-10

Study Status, Contacts/Locations v2

Study sitesdetails revised at 2 of 3 sites

2026-05-13

Study Status, Contacts/Locations v1

Recruitment opened

Study sitesdetails revised at 3 of 3 sites

2026-04-22

Original filing

Alnylam Pharmaceuticals

31 trials monitored

See 5 trials at risk

Hypertension

1,786 trials monitored

See 77 trials at risk

The purpose of this study is to evaluate the efficacy, pharmacodynamics (PD), and safety of ALN-AGT01 RVR in participants with mild to moderate hypertension pretreated with zilebesiran.

Trial Details

NCT Number	NCT07553442
Lead Sponsor	Alnylam Pharmaceuticals Collaborators: Hoffmann-La Roche
Conditions	Hypertension
Enrollment	93 participants
Start Date	2026-04-27
Primary Completion	2028-04-01 (estimated)
Study Completion	2028-10-01 (estimated)
Updated on ClinicalTrials.gov	2026-09-14