26 active trials 19 recruiting 5 Phase 3 9 disease areas 12 changes in 30 days
| Phase 1 | 7 | |
| Phase 1/2 | 3 | |
| Phase 2 | 5 | |
| Phase 3 | 5 |
| NCT ID | Title | Condition | Status | Updated |
|---|---|---|---|---|
| Phase 3 | ||||
| NCT07181109 | Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either… | High Risk Cardiovascular Disease | Recruiting | 2026-09-18 |
| NCT07052903 | TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With… | Transthyretin Amyloidosis With Cardiomyopathy | Recruiting | 2026-09-16 |
| NCT07223203 | TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With… | Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy | Recruiting | 2026-09-15 |
| NCT06679946 | A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With… | Transthyretin Amyloidosis (ATTR) With Cardiomyopathy | Enrolling by Invitation | 2026-02-20 |
| NCT04153149 | HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With… | Transthyretin Amyloidosis (ATTR) With Cardiomyopathy | Active, Not Recruiting | 2026-01-12 |
| Phase 2 | ||||
| NCT07575308 | HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients… | Von Willebrand Disease (VWD) | Recruiting | 2026-09-18 |
| NCT07465224 | A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes… | Type 2 Diabetes Mellitus (T2DM) | Recruiting | 2026-09-16 |
| NCT07553442 | A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension… | Hypertension | Recruiting | 2026-09-14 |
| NCT07636811 | A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down… | Down Syndrome-Associated Alzheimer's Disease (DS-AD) | Recruiting | 2026-09-04 |
| NCT06393712 | A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy | Cerebral Amyloid Angiopathy | Active, Not Recruiting | 2026-09-18 |
| Phase 1/2 | ||||
| NCT07463846 | A Study to Evaluate ALN-2232 in Participants With Obesity | Obesity | Recruiting | 2026-09-16 |
| NCT06659640 | A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary… | Hereditary Hemorrhagic Telangiectasia | Active, Not Recruiting | 2026-09-16 |
| NCT06845202 | A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight… | Obese or Overweight Healthy Volunteers | Active, Not Recruiting | 2026-09-16 |
| Phase 1 | ||||
| NCT06585449 | A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease | Huntington's Disease | Recruiting | 2026-09-16 |
| NCT07295717 | A Study to Evaluate ALN-4285 in Adult Healthy Volunteers | Healthy Volunteers | Recruiting | 2026-09-16 |
| NCT07535606 | A Study to Evaluate ALN-4915 in Adult Healthy Volunteers | Healthy Volunteers | Recruiting | 2026-09-16 |
| NCT05231785 | A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD | Early-Onset Alzheimer Disease | Recruiting | 2026-09-14 |
| NCT07214727 | A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease | Alzheimer's Disease | Recruiting | 2026-09-14 |
| NCT07624071 | A Study to Evaluate ALN-6222 in Participants With Obesity | Obesity | Recruiting | 2026-09-03 |
| NCT06600321 | A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma | Advanced Hepatocellular Carcinoma | Recruiting | 2026-06-17 |
| Not specified | ||||
| NCT07358078 | DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With… | Transthyretin Amyloidosis With Cardiomyopathy | Recruiting | 2026-09-09 |
| NCT04561518 | ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated… | Transthyretin-Mediated Amyloidosis | Recruiting | 2026-09-08 |
| NCT04883905 | ELEVATE, a Registry of Patients With Acute Hepatic Porphyria (AHP) | Acute Hepatic Porphyria | Recruiting | 2026-09-08 |
| NCT05040373 | Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance Program | Hereditary Transthyretin-mediated (hATTR) Amyloidosis | Recruiting | 2026-09-08 |
| NCT04982393 | BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type… | Primary Hyperoxaluria Type 1 | Active, Not Recruiting | 2026-09-08 |
Amyloidosis (8) · Alzheimer's Disease (3) · Obesity (3) · Diabetes (2) · Hypertension (2) · Type 2 Diabetes (2) · Heart Disease (1) · Huntington's Disease (1) · Liver Cancer (1)