Disease landscape

Amyloidosis clinical trials

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222 active trials 136 recruiting 20 Phase 3 140 sponsors 29 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days

2026-09-01
Recruitment suspended
Recruitment suspended: Ongoing adjustments
Primary completion pushed: 2026-10 → 2027-10
Completion pushed: 2026-12 → 2029-10
NCT02952144 Post Approval Study of Lixelle for the Treament of Dialysis-Related Amyloidosis · Kaneka Medical America LLC
2026-08-22
Primary completion pushed: 2026-06-30 → 2026-09-30
Completion pushed: 2026-06-30 → 2026-09-30
NCT07494656 A Retrospective Observational Study of Epidemiology and Outcomes in Transthyretin Amyloid… · Pfizer
2026-08-22
Primary completion pushed: 2026-04-30 → 2027-04-30
NCT04667494 Ultrasound Therapy In Cardiac Amyloidosis · Brigham and Women's Hospital · Phase 4
2026-08-20
Primary completion pushed: 2027-09-01 → 2029-01-01
Sponsor changed: Brigham and Women's Hospital → Dana-Farber Cancer Institute
Trial sites expanded: 1 → 5 locations
Completion moved earlier: 2029-09-01 → 2029-07-01
NCT06569147 Elranatamab in Patients With Relapsed or Refractory AL Amyloidosis · Dana-Farber Cancer Institute · Phase 1/2
2026-09-03
Primary endpoint(s) modified
NCT07752732 Non-Interventional Study on the Prevalence of Cardiac Amyloidosis in Patients With… · University Hospital Tuebingen
2026-08-26
Trial completed
NCT04136171 CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly… · Ionis Pharmaceuticals, Inc. · Phase 3
2026-08-28
Trial completed
Primary completion moved earlier: 2026-12-31 → 2026-04-21
Completion moved earlier: 2026-12-31 → 2026-04-21
NCT04801329 Korean Post-marketing Surveillance Vyndamax® Capsules for the Treatment of Transthyretin… · Pfizer
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07504289 CAR-NK Therapy for Cardiac Amyloidosis · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 1/2
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT04935021 Clinical Study of ATTR-CM · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 4
2026-08-08
Enrollment closed, study ongoing
NCT07338942 Implementation of Standardized Early Identification and Diagnosis for Transthyretin… · AstraZeneca
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT04924998 Clinical Study for AL-CM · Second Affiliated Hospital, School of Medicine, Zhejiang University
2026-08-12
Primary completion pushed: 2026-09-30 → 2026-11-02
Completion pushed: 2026-09-30 → 2026-11-02
NCT06355934 OverTTuRe: Characteristics, Treatment Patterns and Outcomes of Patients With ATTR… · AstraZeneca
2026-08-19
Trial status changed: Recruiting → Enrolling by Invitation
NCT07398950 Prospective Evaluation of Artificial Intelligence-enabled Screening for Transthyretin… · Yale University
2026-08-20
Trial sites expanded: 292 → 295 locations
NCT07207811 CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called… · Novo Nordisk A/S · Phase 3
2026-08-15
Trial sites expanded: 240 → 251 locations
NCT07052903 TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With… · Alnylam Pharmaceuticals · Phase 3
2026-08-15
Trial sites expanded: 41 → 48 locations
NCT07223203 TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With… · Alnylam Pharmaceuticals · Phase 3
2026-08-20
Trial sites expanded: 82 → 89 locations
NCT06465810 Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis · AstraZeneca
2026-08-11
Enrollment increased: 5000 → 10000 participants
NCT06610019 Cardiovascular Multimodality Imaging Study · Montefiore Medical Center
2026-08-29
Completion pushed: 2028-08-28 → 2030-11-15
NCT05652335 A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or… · Janssen Research & Development, LLC · Phase 1

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-25 NCT07784712 Right Ventricular Septal Biopsy to Detect Cardiac Amyloidosis Geisinger Clinic new
2026-08-18 NCT07771621 PET Imaging With [18F]Fluselenamyl in People With Cardiac Amyloidosis Washington University School of Medicine new Phase 1
2026-08-14 NCT07765524 A Phase I/II Open-label, Single-arm, Multicenter Clinical Study to Evaluate the Safety… Shenzhen Fosun Kairos Biotechnology Co., Ltd. new Phase 1/2
2026-08-14 NCT07766135 Liver and Coagulation Disorders in Cardiac Transthyretin Amyloidosis University of Messina new
2026-08-07 NCT07752732 Non-Interventional Study on the Prevalence of Cardiac Amyloidosis in Patients With… University Hospital Tuebingen new
2026-07-23 NCT07721350 Prospective Evaluation of Subcutaneous Administration of Daratumumab by the FreedomEDGE®… Hospices Civils de Lyon new
2026-07-08 NCT07689331 Hungarian National Systemic Amyloidosis Registry Semmelweis University new
2026-06-15 NCT07648303 Prevalence of Cardiac Thrombi in Cardiac Amyloidosis Centre Hospitalier Universitaire Dijon new
2026-06-12 NCT07644325 Concordance for Transthyretin Amyloidosis Between Synovial Biopsy and Anterior Carpal… Clinique Saint Jean, France new

Active trials by phase

Early Phase 1
4
Phase 1
9
Phase 1/2
12
Phase 2
32
Phase 3
20
Phase 4
6
Not charted: 139 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 222

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT04667494 Ultrasound Therapy In Cardiac Amyloidosis Brigham and Women's Hospital Recruiting 2026-08-21
NCT07695701 Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis Eidos Therapeutics, a BridgeBio company Recruiting 2026-07-29
NCT07306949 Real-Life Clinical Efficacy of Acoramidis in Participants With ATTR-CM and Association… Alexion Pharmaceuticals, Inc. Recruiting 2026-01-07
NCT06998875 A Prospective Cohort Study on Primary Cutaneous Amyloidosis Army Medical University, China Recruiting 2025-08-13
NCT04935021 Clinical Study of ATTR-CM Second Affiliated Hospital, School of Medicine, Zhejiang University Recruiting 2023-01-31
NCT05489523 Safety, Efficacy, and Pharmacokinetics of Tafamidis in Patients With… University of Texas Southwestern Medical Center Active, Not Recruiting 2026-06-04
Phase 3
NCT07207811 CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called… Novo Nordisk A/S Recruiting 2026-08-19
NCT07052903 TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With… Alnylam Pharmaceuticals Recruiting 2026-08-14
NCT07223203 TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With… Alnylam Pharmaceuticals Recruiting 2026-08-14
NCT06563895 Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in… Eidos Therapeutics, a BridgeBio company Recruiting 2026-08-04
NCT07560306 [64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy Brigham and Women's Hospital Recruiting 2026-07-21
NCT06022939 Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone… SWOG Cancer Research Network Recruiting 2026-05-06
NCT06672237 A Phase 3 Study of NTLA-2001 in ATTRv-PN Intellia Therapeutics Recruiting 2026-04-16
NCT06128629 MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis… Intellia Therapeutics Recruiting 2026-03-27
NCT07388602 A Study to Evaluate the Safety and Efficacy of SCTC21C in Combination With Bortezomib… Sinocelltech Ltd. Recruiting 2026-02-05
NCT07789483 An Open-Label Study to Evaluate the Long-Term Safety and Efficacy of ALXN2220 in Adults… Alexion Pharmaceuticals, Inc. Not Yet Recruiting 2026-08-28
NCT07793422 Study to Evaluate Change in Disease Activity and Adverse Events of Subcutaneous Etentamig… AbbVie Not Yet Recruiting 2026-08-28
NCT07116473 To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With… Eidos Therapeutics, a BridgeBio company Not Yet Recruiting 2026-08-11
NCT07709715 A Randomized Phase 3 Study to Evaluate the Efficacy and Safety of NXC-201 Compared With… Nexcella Inc. Not Yet Recruiting 2026-07-16
NCT05619302 Molecular Imaging of Myocardial Fibrosis in Cardiac Amyloidosis Brigham and Women's Hospital Active, Not Recruiting 2026-07-06
NCT04504825 A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb… Alexion Pharmaceuticals, Inc. Active, Not Recruiting 2026-07-02
NCT04512235 A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa… Alexion Pharmaceuticals, Inc. Active, Not Recruiting 2026-06-17
NCT05667493 An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With… Ionis Pharmaceuticals, Inc. Enrolling by Invitation 2026-04-17
NCT06679946 A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With… Alnylam Pharmaceuticals Enrolling by Invitation 2026-02-20
NCT04153149 HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With… Alnylam Pharmaceuticals Active, Not Recruiting 2026-01-12
See all 222 active Amyloidosis trials with filters →

Top sponsors by active trials in this area

Alnylam Pharmaceuticals (8) · Fondazione IRCCS Policlinico San Matteo di Pavia (7) · AstraZeneca (6) · Mayo Clinic (6) · Alexion Pharmaceuticals, Inc. (5) · Brigham and Women's Hospital (5) · Peking Union Medical College Hospital (4) · University Hospital, Essen (4) · University of Texas Southwestern Medical Center (4) · Assistance Publique - Hôpitaux de Paris (3)

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