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AstraZeneca clinical trial pipeline

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548 active trials 269 recruiting 192 Phase 3 53 disease areas 133 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-10-11

What changed in the last 30 days

66 trials changed in the last 30 days: 0 stopped, 26 with notable changes, 40 with minor changes only.

  1. Notable

    JASMINE · Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care · Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)

    Primary completion pushed from May 14, 2027 to Jan 10, 2028

    Also in this update: Completion pushed from Aug 4, 2028 to Apr 9, 2029

    AstraZenecaPhase 3 NCT06455449 Registry history of NCT06455449 on ClinicalTrials.gov (opens the registry)

    Updated

Show 40 trials with minor changes only
  1. Minor

    PRCC · Real World Study of Effectiveness of Sunitinib or Sorafenib to Chinese Unresectable Locally Advanced or Metastatic PRCC

    Trial completed

    Also in this update: Primary completion date changed from estimate of Jul 14, 2026 to May 6, 2026; Final enrollment: 48 participants (planned 150)

    AstraZenecaNot specified NCT07024680 Registry history of NCT07024680 on ClinicalTrials.gov (opens the registry)

    Updated

  2. Minor

    eVOLVE-Lung02 · Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy · Metastatic Non-small Cell Lung Cancer

    Trial sites reduced: 247 → 231 locations

    Also in this update: Completion moved earlier from Feb 28, 2029 to Nov 12, 2027; Primary completion date changed from estimate of Feb 28, 2029 to Aug 17, 2026

    AstraZenecaPhase 3 NCT05984277 Registry history of NCT05984277 on ClinicalTrials.gov (opens the registry)

    Updated

  3. Minor

    MONTEROSA · Italian Multicenter Observational Study to Evaluate Time to Clinical Hepatic Decompensation, Quality of Life, Effectiveness, and Safety of Tremelimumab Plus Durvalumab · Advanced or Unresectable Hepatocellular Carcinoma Who Have Received no Prior Systemic Treatment

    Trial sites expanded: 16 → 24 locations

    AstraZenecaNot specified NCT07607769 Registry history of NCT07607769 on ClinicalTrials.gov (opens the registry)

    Updated

  4. Minor

    TROPION-Lung12 · Adjuvant Dato-DXd in Combination With Rilvegostomig or Rilvegostomig Monotherapy Versus Standard of Care, Following Complete Tumour Resection, · Stage I Adenocarcinoma NSCLC Who Are ctDNA-positive or Have High-risk Pathological Features

    Completion moved earlier from Jun 30, 2027 to Mar 31, 2027

    Also in this update: Primary completion date changed from estimate of Jun 30, 2027 to Jul 10, 2026

    AstraZenecaPhase 3 NCT06564844 Registry history of NCT06564844 on ClinicalTrials.gov (opens the registry)

    Updated

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-10-01 NCT07851025 Torvutatug Samrotecan Plus Bevacizumab as First-line Maintenance in Homologous… Phase 3 Recruiting
2026-09-17 NCT07824622 Study of Safety and PK of AZD0543 in Healthy Adults Phase 1 Recruiting
2026-09-14 NCT07816666 Torvutatug Samrotecan With or Without Bevacizumab as Maintenance Treatment of… Phase 3 Not Yet Recruiting

Active trials by phase

Phase 1
60
Phase 1/2
49
Phase 2
73
Phase 2/3
2
Phase 3
190
Phase 4
14
Not charted: 160 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 548

NCT IDTitleConditionStatusUpdated
Phase 4
NCT06531798 Post-marketing Phase 4 Safety & Tolerability Study of Breztri aerosphereTM in Indian… Moderate to Severe COPD Recruiting 2026-10-02
NCT07357597 An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd)… Stomatitis Recruiting 2026-09-30
NCT06651970 Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL… Chronic Lymphocytic Leukaemia Recruiting 2026-09-24
NCT07073950 A Study to Investigate the Effect of Budesonide/Glycopyrronium/Formoterol Fumarate… Chronic Obstructive Pulmonary Disease Recruiting 2026-09-18
NCT06594068 Prospective Registry Investigating Maternal, Infant, and Lactation Outcomes in… Systemic Lupus Erythematosus Recruiting 2026-09-16
NCT07279935 Osimertinib Combined With Chemotherapy in Patients Who Had Distant Recurrence After… Non-small Cell Lung Cancer Recruiting 2026-08-27
NCT07308574 Post-Marketing Clinical Study of Ravulizumab in Participants With Clinical aHUS aHUS Recruiting 2026-04-20
NCT07221838 A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia… Generalized Myasthenia Gravis Recruiting 2026-04-09
NCT07306949 Real-Life Clinical Efficacy of Acoramidis in Participants With ATTR-CM and Association… Transthyretin-type Cardiac Amyloidosis Recruiting 2026-01-07
NCT03953300 Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics Asthma Active, Not Recruiting 2026-09-25
NCT06429761 Phase 4 Study to Assess the Safety of Trastuzumab Deruxtecan, in Indian Patients BREAST CANCER Active, Not Recruiting 2026-09-11
NCT06422689 Combination Short-Acting BroNchodilator and Inhaled Corticosteroid Rescue Therapy on… Asthma Active, Not Recruiting 2026-07-16
NCT05457257 Clinical Study to Assess the Efficacy and Safety of Olaparib in Chinese Patients With… Metastatic Castration-resistant Prostate Cancer Active, Not Recruiting 2026-04-21
NCT06610526 A Study of Dapagliflozin in Chinese Adult Patients With Chronic Kidney Disease Chronic Kidney Disease Active, Not Recruiting 2026-01-30
Phase 3
NCT06307665 Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in… Asthma Recruiting 2026-10-09
NCT06878261 A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With… Chronic Obstructive Pulmonary Disease (COPD) Recruiting 2026-10-09
NCT07215585 AZD0486 1L Therapy for Elderly or Unfit Participants With LBCL Large B-cell Lymphoma Recruiting 2026-10-09
NCT06023589 A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in… Asthma Recruiting 2026-10-06
NCT07509151 Surovatamig as Consolidation Therapy in Participants With Chronic Lymphocytic Leukaemia… Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated IGHV Recruiting 2026-10-06
NCT07619118 A Phase III Study to Assess the Effect of FDC Laroprovstat/Rosuvastatin Compared With… Hypercholesterolaemia Recruiting 2026-10-05
NCT05624450 Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection… Viral Lung Infection and Acute Respiratory Failure Recruiting 2026-10-02
NCT06283966 A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate… COPD (Chronic Obstructive Pulmonary Disease) Recruiting 2026-10-02
NCT06307652 Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure… Heart Failure and Impaired Kidney Function Recruiting 2026-10-02
NCT07205822 A Study of Dato-DXd in Inoperable or Metastatic Hormone Receptor-positive, HER2 IHC 0… Breast Cancer Recruiting 2026-10-02
NCT07691970 Rollover Study for Participants Who Have Completed a Previous Clinical Study With… Systemic Sclerosis Cutaneous Lupus E Myopathies Systemic Lupus Erythematosus Recruiting 2026-10-02

Disease areas by active trials, top 10 of 53

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